Head-to-head comparisons of medication uses, side effects, warnings, and more.
Key takeaways
Nystatin topical and Oravig (miconazole) are both antifungal medications used to treat infections caused by fungi. Nystatin topical is used for fungal skin infections, while Oravig (miconazole) is used for oral thrush in the mouth and throat. Nystatin topical is available in cream, ointment, and powder forms and is applied directly to the skin, whereas Oravig (miconazole) comes as a buccal tablet that dissolves in the mouth. Nystatin topical is available as a lower-cost generic, but Oravig (miconazole) does not have a generic version. Common side effects of nystatin topical include burning and itching at the application site, while Oravig (miconazole) can cause mouth discomfort, diarrhea, and headache. Nystatin topical is safe for all ages, including babies, but Oravig (miconazole) is only recommended for people 16 years and older. Both medications require a prescription and are not available over the counter.
Nystatin topical
Oravig (miconazole)
Nystatin topical
Oravig (miconazole)
Summary of Nyamyc vs. Oravig
Summary for Antifungal
Prescription only
Nystatin topical is a prescription antifungal you use on your skin to treat certain fungal skin infections, like yeast infections. It's safe for all ages, even babies with diaper rash. Nystatin topical comes as a cream, ointment, or powder. You usually apply it to the affected skin 2 to 3 times a day. Sometimes, it can cause mild side effects like itching or burning where you put it on.
Summary for Antifungal
Prescription only
Oravig (miconazole) treats fungal infections in the mouth and throat (oral thrush). This medication comes as a tablet that dissolves against your gum in your mouth, so it might be more difficult to use than other medications. The most common side effects of Oravig (miconazole) include upset stomach (e.g., diarrhea, nausea) and headache.