Key takeaways
Itraconazole (Sporanox, Tolsura) and fluconazole (Diflucan) are both antifungal medications, but they have some key differences. Itraconazole is used to treat severe fungal infections like blastomycosis, histoplasmosis, and aspergillosis, as well as fungal nail infections. It must be taken with food and can cause serious heart-related side effects. Fluconazole, on the other hand, is used for various Candida infections, including vaginal yeast infections and oral thrush, and can also treat cryptococcal meningitis. It can be taken with or without food and is generally well-tolerated, though it can cause liver problems. Itraconazole interacts with many medications and has a higher risk of causing heart and liver issues, while fluconazole is considered safer for breastfeeding but is not recommended during pregnancy. Both medications are available in generic forms, making them more affordable.
