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Diflucan vs. Monistat

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Fluconazole

(Diflucan)

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Miconazole

(Monistat)

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Summary for Diflucan

Prescription only

Fluconazole (Diflucan) is an azole antifungal. It's used to treat different types of Candida infections, such as vaginal yeast infections and oral thrush. It can also treat a serious brain infection called cryptococcal meningitis. Oral fluconazole (Diflucan) is available as a tablet and suspension. It's taken by mouth as a one-time dose for vaginal yeast infections; it's typically taken once daily for other types of infections. Fluconazole (Diflucan) is generally well-tolerated, but some people can experience side effects like headache, nausea, and stomach pain. Fluconazole (Diflucan) can raise the risk of liver problems, so you're recommend to avoiding drinking alcohol while taking this medication.

Indications for Diflucan

Pros and Cons for Diflucan

Pros

  • Taken once daily for most infections
  • Considered acceptable to take while breastfeeding
  • Oral liquid comes flavored for better taste
  • Available as a lower-cost generic

Cons

Common Side Effects for Diflucan

Single dose for vaginal yeast infection:

  • Headache (13%)
  • Nausea (7%)
  • Stomach pain (6%)
  • Diarrhea (3%)

Multiple doses for other infections:

  • Nausea (4%)
  • Headache (2%)
  • Skin rash (2%)
  • Vomiting (2%)
  • Stomach pain (2%)
  • Diarrhea (2%)

Warnings for Diflucan

  • Liver damage
  • Allergic reaction
  • Severe skin reaction
  • Harm to unborn babies

Summary for Monistat

Over-the-counter

Miconazole (Monistat) is used to treat a vaginal yeast infection in adults and children 12 years and older. It's available over the counter as vaginal creams, inserts/suppositories, or combination kits. The entire treatment lasts 1, 3, or 7 days, depending on the product. Common side effects include mild vaginal burning, irritation, and itching.

Indications for Monistat

Pros and Cons for Monistat

Pros

  • Available over the counter
  • Many treatment options (1, 3, or 7 days)
  • Targets infection directly at the site

Cons

  • Can cause vaginal burning, itching, or irritation
  • Might be messy or cause leakage
  • Requires vaginal insertion

Common Side Effects for Monistat

Warnings for Monistat

  • Damage to condoms and diaphragms
  • Symptoms don't go away

Prices with our coupons for Diflucan vs. Monistat

Price Card Drug Icon
Fluconazole2 tablets / 150mg
$10.16$43.76
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Price Card Drug Icon
Miconazole30 tubes / 2%
$11.34-
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