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Compare Noxafil vs. Diflucan

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Posaconazole (Noxafil) and Fluconazole (Diflucan) are both antifungal medications, but they have some key differences. Posaconazole is used to prevent and treat serious fungal infections caused by *Candida* and *Aspergillus*.It is known for its many drug interactions and potential for liver and kidney damage. On the other hand, Fluconazole is used to treat various *Candida* infections, such as vaginal yeast infections and oral thrush, and can also treat cryptococcal meningitis. Fluconazole is generally well-tolerated. While both medications can cause liver problems, Posaconazole has a higher risk of serious side effects and drug interactions. Additionally, Posaconazole is not recommended for pregnant women due to potential harm to unborn babies, whereas Fluconazole is generally avoided during pregnancy unless necessary. Both medications are available as a lower-cost generic and available in multiple forms, including oral and intravenous.

  • Posaconazole (Noxafil) infusion
    Fluconazole (Diflucan)
  • Posaconazole (Noxafil) infusion
    Fluconazole (Diflucan)

  • Summary of Noxafil vs. Diflucan

    Summary for Antifungal
    Prescription only

    Posaconazole (Noxafil) infusion is an azole antifungal. It's used to treat serious Aspergillus fungal infections in adults and children ages 13 years and older. It's also used to prevent Candida and Aspergillus infections (prophylaxis) in adults and children ages 2 years and older with weakened immune systems. Posaconazole (Noxafil) infusion is given as an infusion into the veins, typically twice a day on the first day and then once a day thereafter. This medication is available under the brand name Noxafil and as a lower-cost generic. Common side effects include diarrhea, nausea, and abnormal liver tests.

    Summary for Antifungal
    Prescription only

    Fluconazole (Diflucan) is an azole antifungal. It's used to treat different types of Candida infections, such as vaginal yeast infections and oral thrush. It can also treat a serious brain infection called cryptococcal meningitis. Oral fluconazole (Diflucan) is available as a tablet and suspension. It's taken by mouth as a one-time dose for vaginal yeast infections; it's typically taken once daily for other types of infections. Fluconazole (Diflucan) is generally well-tolerated, but some people can experience side effects like headache, nausea, and stomach pain. Fluconazole (Diflucan) can raise the risk of liver problems, so you're recommend to avoiding drinking alcohol while taking this medication.

  • Indications of Noxafil vs. Diflucan

    Indications for
    •Prevention of serious fungal infections caused by Candida and Aspergillus
    •Treatment of serious Aspergillus infection
    Indications for
    •Treatment of infections caused by Candida:
    •Vaginal yeast infections
    •Mouth, throat, or esophagus infections, including oral thrush
    •Bloodstream infections
    •Urinary tract infections (UTIs)
    •Peritonitis (infection of the lining of the stomach)
    •Pneumonia
    •Prevention of Candida fungal infections for people having a bone marrow transplant
    •Cryptococcus meningitis

  • Pros and Cons of Noxafil vs. Diflucan

    Pros and Const for Antifungal
    Pros
    •Can be used in adults and children
    •Once-daily dosing after the first day
    •A good option for people who can't take medications by mouth
    Cons
    •Many interactions with other medications
    •Might not be a good option for people with moderate or severe kidney problems
    •Might not be safe during pregnancy
    Pros and Const for Antifungal
    Pros
    •Taken once daily for most infections
    •Considered acceptable to take while breastfeeding
    •Oral liquid comes flavored for better taste
    •Available as a lower-cost generic
    Cons
    •Interacts with many medications
    •Not recommended during pregnancy due to the potential risk of harm to babies
    •Rare risk of liver problems

  • Common Side Effects of Noxafil vs. Diflucan

    Common Side Effects for
    •Diarrhea (32%)
    •Low potassium levels (22%)
    •Fever (21%)
    •Nausea (19%)
    •Rash (15%)
    •Nose bleed (14%)
    •Headache (14%)
    •Stomach pain (13%)
    •Vomiting (12%)
    •Chills (12%)
    •Swelling in arms or legs (12%)

    Note: The side effects listed above were reported by adults taking posaconazole (Noxafil) infusion for prevention of fungal infections.

    Common Side Effects for

    Single dose for vaginal yeast infection:

    •Headache (13%)
    •Nausea (7%)
    •Stomach pain (6%)
    •Diarrhea (3%)

    Multiple doses for other infections:

    •Nausea (4%)
    •Headache (2%)
    •Skin rash (2%)
    •Vomiting (2%)
    •Stomach pain (2%)
    •Diarrhea (2%)

  • Warnings of Noxafil vs. Diflucan

    Common Side Effects for
    •QT prolongation (heart rhythm problem)
    •Changes in electrolytes
    •Liver damage
    •Interaction with transplant medications
    •Interaction with midazolam
    •Interaction with vincristine
    •Interaction with venetoclax
    Common Side Effects for
    •Liver damage
    •Allergic reaction
    •Severe skin reaction
    •Harm to unborn babies

  • Prices with our coupons for Noxafil vs. Diflucan

    Learn more about Posaconazole
    Learn more about Fluconazole

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