Key takeaways
Clotrimazole (Lotrimin AF) and ketoconazole (Nizoral) are both antifungal creams used to treat skin infections like athlete's foot, ringworm, and jock itch. However, there are some key differences between the two. Clotrimazole is available over the counter, making it easier to access, while ketoconazole requires a prescription. Clotrimazole needs to be applied twice daily, whereas ketoconazole is used just once a day. Additionally, ketoconazole can treat more types of infections, such as tinea versicolor and seborrheic dermatitis, which clotrimazole does not. Clotrimazole is safe for children 2 years and older, but ketoconazole is only approved for adults. Both medications have few side effects, but ketoconazole can cause allergic reactions in people with asthma or sulfite allergies.
