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Compare Sporanox vs. Nystop

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Itraconazole (Sporanox, Tolsura) and nystatin (Nystop, Nyamyc, Klayesta) are both antifungal medications, but they have different uses and forms. Itraconazole is taken orally and is used to treat serious fungal infections like blastomycosis, histoplasmosis, and aspergillosis, as well as fungal nail infections. It must be taken with food and can interact with many other medications, leading to serious side effects like heart problems and liver damage. On the other hand, nystatin is applied topically and is used to treat fungal skin infections, such as yeast infections. It comes in various forms like cream, ointment, and powder, and is generally well-tolerated with few side effects. Unlike itraconazole, nystatin is safe for use in newborns and doesn't have the same risk of severe side effects. However, nystatin needs to be applied multiple times a day.

  • Itraconazole (Sporanox) capsule
    Nystatin topical
  • Itraconazole (Sporanox) capsule
    Nystatin topical

  • Summary of Sporanox vs. Nystop

    Summary for Antifungal
    Prescription only

    Itraconazole (Sporanox) capsule is used to treat various fungal infections. You might have to take it for several weeks or months. It interacts with many medications, which can lead to serious heart-related side effects.

    Summary for Antifungal
    Prescription only

    Nystatin topical is a medication that's used on the skin to treat certain fungal skin infections (most commonly yeast infections). It's safe to use in people of all ages, including babies for diaper rash. Nystatin topical comes in different formulations: cream, ointment, and powder. It's available by prescription only and can't be purchased over the counter. Rarely, some people experience itching and burning where they applied the medication. But most people experience few to no side effects while using nystatin topical as directed.

  • Indications of Sporanox vs. Nystop

    Indications for

    Severe fungal infections in people with weakened or healthy immune systems - itraconazole (Tolsura) and itraconazole (Sporanox) capsule:

    •Blastomycosis
    •Histoplasmosis
    •Aspergillosis in people in which amphotericin b (Ambisome) hasn't worked or isn't tolerated

    Fungal toenail and fingernail infections (onychomycosis) for people with healthy immune systems - itraconazole (Sporanox) capsule only

    Indications for
    •Treatment of fungal skin infections (yeast infection)

  • Pros and Cons of Sporanox vs. Nystop

    Pros and Const for Antifungal
    Pros
    •Works to treat some serious and life-threatening fungal infections
    •Available as a lower-cost generic
    •Can be taken once a day for most conditions
    Cons
    •Can raise your risk for serious heart problems, including heart failure
    •Must be taken for several weeks to months
    •Interacts with many medications
    Pros and Const for Antifungal
    Pros
    •Available as a lower-cost generic medication
    •Many formulations to choose from, such as ointment, cream, and powder
    •Generally well-tolerated
    •Safe to use for newborns
    Cons
    •Applied onto skin multiple times a day
    •Only treats some fungal skin infections, not bacterial or viral infections
    •Might not work as well as antifungal medications that are taken by mouth
    •Not clear whether it's safe to use during pregnancy or while breastfeeding

  • Common Side Effects of Sporanox vs. Nystop

    Common Side Effects for
    •Nausea (11%)
    •Rash (3-9%)
    •Vomiting (5%)
    •Swelling in the arms and legs (4%)
    •Headache (1-4%)
    Common Side Effects for
    •Burning
    •Itching
    •Rash
    •Eczema (dry, bumpy skin)
    •Pain when applying the medication onto the skin

  • Warnings of Sporanox vs. Nystop

    Common Side Effects for
    •Congestive heart failure (CHF)
    •Abnormal heart rhythm (QT prolongation)
    •Liver damage
    •Interactions with other medications
    •Hearing loss
    •Vision problems
    •Nerve damage (peripheral neuropathy)
    Common Side Effects for
    •Allergic reaction
    •Use only on your skin

  • Prices with our coupons for Sporanox vs. Nystop

    Learn more about Itraconazole
    Learn more about Nystatin topical

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