Head-to-head comparisons of medication uses, side effects, warnings, and more.
Key takeaways
Itraconazole (Sporanox, Tolsura) and nystatin (Nystop, Nyamyc, Klayesta) are both antifungal medications, but they have different uses and forms. Itraconazole is taken orally and is used to treat serious fungal infections like blastomycosis, histoplasmosis, and aspergillosis, as well as fungal nail infections. It must be taken with food and can interact with many other medications, leading to serious side effects like heart problems and liver damage. On the other hand, nystatin is applied topically and is used to treat fungal skin infections, such as yeast infections. It comes in various forms like cream, ointment, and powder, and is generally well-tolerated with few side effects. Unlike itraconazole, nystatin is safe for use in newborns and doesn't have the same risk of severe side effects. However, nystatin needs to be applied multiple times a day.
Itraconazole (Sporanox) capsule
Nystatin topical
Itraconazole (Sporanox) capsule
Nystatin topical
Summary of Sporanox vs. Nyamyc
Summary for Antifungal
Prescription only
Itraconazole (Sporanox) capsule is used to treat various fungal infections. You might have to take it for several weeks or months. It interacts with many medications, which can lead to serious heart-related side effects.
Summary for Antifungal
Prescription only
Nystatin topical is a prescription antifungal you use on your skin to treat certain fungal skin infections, like yeast infections. It's safe for all ages, even babies with diaper rash. Nystatin topical comes as a cream, ointment, or powder. You usually apply it to the affected skin 2 to 3 times a day. Sometimes, it can cause mild side effects like itching or burning where you put it on.
Indications of Sporanox vs. Nyamyc
Indications for
Severe fungal infections in people with weakened or healthy immune systems - itraconazole (Tolsura) and itraconazole (Sporanox) capsule: