Key takeaways
Itraconazole (Sporanox, Tolsura) and nystatin (Nystop, Nyamyc, Klayesta) are both antifungal medications, but they have different uses and forms. Itraconazole is taken orally and is used to treat serious fungal infections like blastomycosis, histoplasmosis, and aspergillosis, as well as fungal nail infections. It must be taken with food and can interact with many other medications, leading to serious side effects like heart problems and liver damage. On the other hand, nystatin is applied topically and is used to treat fungal skin infections, such as yeast infections. It comes in various forms like cream, ointment, and powder, and is generally well-tolerated with few side effects. Unlike itraconazole, nystatin is safe for use in newborns and doesn't have the same risk of severe side effects. However, nystatin needs to be applied multiple times a day.
