Polyene antifungals are used to treat fungal infections in many parts of the body. These medications work by binding to the fungal cell membrane, causing it to become porous and eventually leading to cell death. Polyene antifungals come in different forms, including oral, topical, and injectable options. Examples include nystatin (Nystop, Nyamyc), natamycin (Natacyn), and amphotericin B (Ambisome, Abelcet). You can choose the form that best fits your needs.