Head-to-head comparisons of medication uses, side effects, warnings, and more.
Key takeaways
Terbinafine (Lamsil) and nystatin are both antifungal medications, but they have different uses and forms. Terbinafine is taken orally and is primarily used to treat fungal infections of the fingernails and toenails. It is a first-choice treatment for these infections and is taken once daily for several weeks. Common side effects include headache, rash, and upset stomach. Nystatin, on the other hand, is used topically to treat fungal skin infections, such as yeast infections. It comes in various forms like cream, ointment, and powder, and is applied directly to the skin multiple times a day. Nystatin is generally well-tolerated, but some people may experience itching or burning at the application site. While terbinafine can interact with other medications and has potential serious side effects like liver damage, nystatin is considered safer for a wider range of people, including babies. Both medications are available in generic versions, but only terbinafine has over-the-counter topical forms available.
Terbinafine
Nystatin topical
Terbinafine
Nystatin topical
Summary of Terbinafine vs. Nyamyc
Summary for Antifungal
Prescription only
Terbinafine is a first-choice treatment option for fingernail and toenail fungus. It's available as once-daily tablets, but treatment can take many weeks. Common side effects of terbinafine include headache, rash, diarrhea, and upset stomach. Terbinafine can have interactions with other medications, including certain antidepressants, beta-blockers, and some medications that treat an irregular heart rhythm.
Summary for Antifungal
Prescription only
Nystatin topical is a prescription antifungal you use on your skin to treat certain fungal skin infections, like yeast infections. It's safe for all ages, even babies with diaper rash. Nystatin topical comes as a cream, ointment, or powder. You usually apply it to the affected skin 2 to 3 times a day. Sometimes, it can cause mild side effects like itching or burning where you put it on.