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Posaconazole Coupon - Posaconazole 100mg tablet

posaconazole

Generic Noxafil
Used for Candidiasis, Fungal Infection, Thrush
Used for Candidiasis, Fungal Infection, Thrush

Oral posaconazole (Noxafil) is an azole antifungal. It's taken by mouth to prevent and treat serious Aspergillus and Candida fungal infections in adults and children. Posaconazole (Noxafil) is available as an oral suspension and tablet (both brand name and generic), as well as powder for oral suspension (brand only). Posaconazole (Noxafil) is also available as an intravenous infusion that's typically given in a hospital setting by a healthcare professional. The dosing depends on what condition you're taking it to treat, your age, and which formulation you're taking. Potential side effects include diarrhea, nausea, and abnormal liver tests.

Reviewed by:
reviewer
Kristianne Hannemann, PharmD
reviewer
Connie Zheng, PharmD
Last reviewed on September 24, 2024
BasicsSide effectsPros & consPharmacist tipsFAQsWarningsDosageInteractionsCostContraindicationsAlternativesLatest newsImagesReferencesPricesMedicare
basics-icon

What is Posaconazole (Noxafil)?

What is Posaconazole (Noxafil) used for?

  • Prevention of serious fungal infections caused by Candida and Aspergillus

  • Treatment of serious Aspergillus infection - tablets only

  • Treatment of oral thrush of the mouth and throat - liquid suspension only

How Posaconazole (Noxafil) works

Posaconazole (Noxafil) is an azole antifungal. It works by damaging the protective outer layer of the fungus causing your infection.

Are you looking for information on posaconazole (Noxafil) injection instead?

Drug Facts

Common BrandsNoxafil
Drug ClassAntifungal
Controlled Substance ClassificationNot a controlled medication
Generic StatusLower-cost generic available
AvailabilityPrescription only
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$4736.19(save 94.72%)
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$249.98
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What are the side effects of Posaconazole (Noxafil)?

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Diarrhea (up to 29%)
  • Fever (28%)
  • Nausea (27%)
  • Low potassium levels (22%)
  • Cough (17%)
  • Rash (16%)
  • Swelling of the arms or legs (16%)
  • Lower blood cell counts (up to 14%)
  • Inflammation of mucus membranes (14%)
  • Headache (14%)
  • Nosebleeds (14%)
  • Vomiting (13%)
Note: Side effects above reported by adults taking the tablets for prevention of fungal infection.

Other Side Effects

  • Constipation
  • Stomach pain
  • Weakness
  • Chills
  • High blood pressure

Serious Side Effects

Contact your healthcare provider immediately if you experience any of the following.
  • Serious liver problems: nausea, vomiting, stomach pain, yellowing of the skin or whites of the eyes, flu-like symptoms
  • Abnormal heart rhythm: irregular heartbeat, racing heart, chest pain, dizziness
  • Changes in electrolytes: nausea, vomiting, muscle cramps, muscle weakness, abnormal heartbeat, feeling tired

Source: DailyMed

The following side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

Abdominal or stomach pain

black, tarry stools

bloody nose

blurred vision

body aches or pain

confusion

cough

diarrhea

difficult or labored breathing

dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position

drowsiness

fever or chills

fruit-like breath odor

heavy non-menstrual vaginal bleeding

increased thirst or urination

irregular heartbeats

loss of voice

muscle pain, spasms, or twitching

nausea or vomiting

numbness or tingling in the hands, feet, lips, mouth, or fingertips

painful cold sores or blisters on the lips, nose, eyes, or genitals

painful or difficult urination

pounding in the ears

slow or fast heartbeat

small red or purple spots on the skin

sores, ulcers, or white spots on the lips, tongue, or inside the mouth

sweating

tender, swollen glands in the neck

tightness in the chest

trembling

trouble swallowing

unexplained weight loss

yellow eyes or skin

Less common

Fainting

irregular heartbeat, recurrent

Incidence not known

Anxiety

change in mental status

chest pain or discomfort

darkening of the skin

itching or skin rash

mental depression

seizures

sudden shortness of breath or troubled breathing

swelling of the eyes or eyelids

swelling of the face, fingers, feet, or lower legs

weakness

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Acid or sour stomach

back pain

belching

difficulty having a bowel movement (stool)

heartburn

muscle stiffness

pain in the joints

trouble sleeping

Less common

Bad, unusual, or unpleasant (after) taste

change in taste

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

pros-and-cons

Pros and cons of Posaconazole (Noxafil)

thumbs-up

Pros

Available as a tablet and oral liquid

Some formulations available as a lower-cost generic

Possible option when other antifungals aren't working for oral thrush

thumbs-down

Cons

Some forms must be taken multiple times per day

Can interact with many medications

Might not be a good option during pregnancy

pharmacist-tips

Pharmacist tips for Posaconazole (Noxafil)

pharmacist

  • Continue to take posaconazole (Noxafil) even if you start to feel better. Stopping too early can cause your infection to come back and be harder to treat.

    • Posaconazole (Noxafil) interacts with many medications, including alprazolam (Xanax), simvastatin (Zocor), and phenytoin (Dilantin). This isn't a complete list of all drug interactions, so please speak with your healthcare professional before starting posaconazole (Noxafil). Be sure to tell them about any over-the-counter medications, vitamins, and herbal products you take.

      • Tell your care team if you experience severe diarrhea or vomiting while taking posaconazole (Noxafil). These might be signs that posaconazole (Noxafil) isn't working well to treat your infection and that you need more medical attention.

        Additional tips for taking the tablets:

        • You can take posaconazole (Noxafil) tablets with or without food.

          • Swallow the tablets whole and don't crush, break, or chew them because this could change how the medication works in your body.

            • Store the tablets at room temperature.

              Additional tips for the oral suspension:

              • Shake posaconazole (Noxafil) oral suspension well each time before taking a dose.

                • Make sure to take posaconazole (Noxafil) oral suspension at the same time as or within 20 minutes of a full meal. This will help the medication to be absorbed by your body and work better. If you can't eat a full meal, you can take posaconazole (Noxafil) with a nutritional supplement drink (Boost, Ensure, etc.) or an acidic carbonated beverage like ginger ale.

                  • Only use the dosing spoon that comes with posaconazole (Noxafil) oral suspension and rinse it after each use. Don't use household spoons because this can cause you to take or give the wrong dose.

                    • Store posaconazole (Noxafil) oral suspension at room temperature.

                      Additional tips for taking Noxafil PowderMix for delayed-release oral suspension:

                      • Make sure to read the Instructions for Use before using Noxafil (posaconazole) PowderMix for oral suspension and keep them handy each time you mix and give the medication.

                        • Don't open the Noxafil (posaconazole) PowderMix foil packet until you're ready to use it.

                          • Only use the syringe that comes with the medication to prepare and give Noxafil (posaconazole) PowderMix.

                            • Once you mix Noxafil (posaconazole) PowderMix, give the dose within 1 hour and with food.

                              • Call your child's prescriber if they spit some of the dose out or don't take the full dose.

                                faqs

                                Frequently asked questions about Posaconazole (Noxafil)

                                How long should posaconazole (Noxafil) be taken?
                                The amount of time you should take posaconazole (Noxafil) depends on things like the reason you're taking it, how long you're at risk for infection, or how serious your infection is. If you're taking posaconazole (Noxafil) to prevent a serious fungal infection, your prescriber will likely have you take it until you're no longer at risk, such as when your immune system is stronger. If you're taking posaconazole (Noxafil) to treat fungal infection in the mouth and throat (oral thrush), treatment usually lasts 2 weeks, but can be longer if your infection isn't getting better. And if you have a severe Aspergillus infection, your healthcare team might ask you to take posaconazole (Noxafil) 6-12 weeks. Follow up with your care team to understand how long you'll need to take posaconazole (Noxafil).
                                Can posaconazole (Noxafil) tablets be crushed?
                                No, posaconazole (Noxafil) tablets shouldn't be crushed, chewed, or split. This is because they're delayed-release tablets, meaning they're made to slowly release the medication in your body; crushing them could affect how the medication works. If you're having trouble swallowing the tablets, ask your prescriber about taking a liquid version instead. Keep in mind that if you switch between the tablet and oral suspension your dose might be different.
                                Does dairy affect posaconazole (Noxafil)?
                                Dairy products aren't known to interact with posaconazole (Noxafil). If you're taking the oral suspension (including Noxafil PowderMix for oral suspension), it's recommended to take it with food, including foods that contain dairy. But if you're taking the Noxafil PowderMix, never mix the powder with milk; only mix it with the mixing liquid that comes with the kit.
                                Does posaconazole (Noxafil) lower white blood cell count?
                                Some people taking posaconazole (Noxafil) during clinical studies did experience having lower white blood cell count. But it's unclear if this was caused by posaconazole (Noxafil) or another reason. Taking posaconazole (Noxafil) with certain medications, such as Venclexta (venetoclax), can raise your risk for lower white blood cell counts. Make sure to tell your care team about all of the medications you're taking before starting posaconazole (Noxafil). They can watch your white blood cell count through blood tests.
                                Does posaconazole (Noxafil) cause hair loss?
                                Hair loss wasn't a commonly-reported side effect during studies of posaconazole (Noxafil). If you notice more hair falling out, contact your primary care provider so they can help you determine the cause.
                                Are the posaconazole (Noxafil) tablets and suspension the same thing?
                                No, posaconazole (Noxafil) tablets and suspension are made differently and have different dosing recommendations. If you want to switch between the tablet and liquid forms, you'll need to consult with your healthcare professional so they can make sure you're taking the correct dosage and write. you a new prescription.
                                Is posaconazole (Noxafil) safe during pregnancy?
                                Based on animal studies, posaconazole (Noxafil) can cause harm to unborn babies when taken during pregnancy. There aren't enough studies in humans to know how safe this medication is to take while pregnant. Tell your prescriber right away if you become pregnant while taking posaconazole (Noxafil) because they might ask you to consider other options.
                                What do I do if I missed my dose of posaconazole (Noxafil)?
                                If you miss your dose of posaconazole (Noxafil), take it as soon as you remember. But if it's almost time for your next dose (less than 12 hours until the next dose for the tablets), skip the dose you missed and just take your next dose at your regular time. Never double up or take extra doses of posaconazole (Noxafil) to make up for missed doses. If you have questions about missing a dose, contact your care team.
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                                What are the risks and warnings for Posaconazole (Noxafil)?

                                Posaconazole (Noxafil) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

                                risk-warning

                                Risk of posaconazole not working well

                                Call for medical help and let your healthcare team know right away if you have severe diarrhea or vomiting. These might be signs that posaconazole (Noxafil) isn't working well to treat your fungal infection. If so, you'll need more medical attention immediately from your care team.

                                risk-warning

                                Liver damage

                                • Risk factors: History of liver problems

                                  Posaconazole (Noxafil) can cause liver problems. Most of the time, you won't experience any symptoms. But your healthcare team might note higher liver enzyme levels on blood work that checks your liver health. Typically, your liver enzyme levels should go back to the normal range once you stop taking posaconazole (Noxafil). But rarely, people have experienced serious liver problems that were life-threatening. As a precaution, your healthcare team might order blood work regularly during treatment to check your liver health. If there are signs of liver problems, they might ask you to stop taking posaconazole (Noxafil). Get medical help right away if you feel symptoms of serious liver problems, such as unexplained stomach pain, nausea, or vomiting, dark urine, pale stools, or yellowing of your skin or eyes.

                                  risk-warning

                                  QT prolongation (heart rhythm problem)

                                  • Risk factors: History of abnormal heart rhythm | Taking other medications that cause heart rhythm problem | Taking medications that cause posaconazole (Noxafil) to build up in your body

                                    Posaconazole (Noxafil) can cause a serious heart rhythm problem called QT prolongation. The risk is higher for people who already have heart rhythm problems or are taking medications that also have a risk of causing heart rhythm problems. Let your healthcare team know about all medications and supplements you're taking so they can check if you're at higher risk for QT prolongation.

                                    risk-warning

                                    Changes in electrolytes

                                    Posaconazole (Noxafil) can cause changes to electrolytes levels in your body like potassium, magnesium, and calcium. Usually, this change is minor and can be corrected with supplements. But if these levels drop too low, they can cause problems with your heart. Make sure you get any blood tests ordered by your prescriber done on time while taking posaconazole (Noxafil). This will help them catch problems earlier.

                                    risk-warning

                                    Multiple drug interactions

                                    Posaconazole (Noxafil) is known to interact with many medications, including over-the-counter vitamins and herbals. Some of these interactions can be dangerous or life-threatening. Make sure to tell both your healthcare team about all medications and over-the-counter products you are taking before you start posaconazole (Noxafil), even if you only take them once in a while or as needed.

                                    risk-warning

                                    Interaction with transplant medications

                                    • Risk factors: Taking calcineurin-inhibitors

                                      Posaconazole (Noxafil) interacts with medications known as calcineurin inhibitors, which are usually taken by people who have had organ transplants or have certain immune conditions. Examples include cyclosporine (Sandimmune, Neoral) and tacrolimus (Prograf). Posaconazole (Noxafil) can cause these medications to build up in your body. This can cause serious problems like brain damage (leukoencephalopathy) and kidney damage, which can be life-threatening. Be sure to tell your care team all the medications you take before starting posaconazole (Noxafil) so they can help you check for interactions.

                                      risk-warning

                                      Interaction with midazolam

                                      Posaconazole (Noxafil) interacts with midazolam (Seizalam), a medication used for seizures and anesthesia. Posaconazole (Noxafil) causes midazolam to build up in your body, making it more likely you'll have side effects or have trouble waking up. This interaction is life-threatening, so you shouldn't take these two medications together. Make sure you tell your prescriber if you take midazolam before starting posaconazole (Noxafil). If you need to have any surgical procedures done while taking posaconazole (Noxafil), be sure to tell your surgeon you are taking this medication so they can pick anesthesia that won't interact with posaconazole (Noxafil).

                                      risk-warning

                                      Interaction with vincristine

                                      Posaconazole (Noxafil) interacts with a cancer medication called vincristine. Taking these medications together can cause seizures, nerve damage, or bowel blockages. Make sure you tell the healthcare professional prescribing posaconazole (Noxafil) if you take any cancer medications. Your healthcare team might only ask you to take this combination if there are no safer alternative treatments available. If so, they'll go over the risks and benefits of treatment and monitor you closely for side effects.

                                      risk-warning

                                      Interaction with venetoclax

                                      Posaconazole (Noxafil) interacts with a medication called Venclexta (venetoclax). Taking these medications together can raise the risk of life-threatening side effects, such as tumor lysis syndrome (TLS) and serious infections. Review of list of your current medications with your prescriber before taking posaconazole (Noxafil). Your healthcare team can help you check for interactions and talk with you about alternative options if needed.

                                      risk-warning

                                      Problems in people with hereditary fructose intolerance (Noxafil PowderMix only)

                                      Noxafil PowderMix for delayed-release oral suspension contains sorbitol, which can cause life-threatening problems in people with hereditary fructose intolerance (HFI). Some problems include dangerously low blood sugar levels, lactic acidosis, and liver failure. Tell your prescriber if you have a history of HFI so they can prescribe the safest formulation of posaconazole (Noxafil) for you.

                                      dosage

                                      Posaconazole (Noxafil) dosage forms

                                      The average cost for 90 tablets of 100mg of Posaconazole (Noxafil) is $249.98 with a free GoodRx coupon. This is 94.72% off the average retail price of $4736.19.
                                      bottle of oral suspension
                                      Bottle of oral suspension
                                      DosageQuantityPrice as low asPrice per unit
                                      105ml of 200mg/5ml1 bottle$256.16$256.16
                                      tablet
                                      Tablet
                                      DosageQuantityPrice as low asPrice per unit
                                      100mg90 tablets$249.98$2.78

                                      Typical dosing for Posaconazole (Noxafil)

                                      Treatment of serious Aspergillus infection:

                                      • Delayed-release tablets:

                                        • Adults and children ages 13 to 17 years old: The typical dose is 300 mg by mouth twice a day on Day 1, followed by 300 mg once a day starting on Day 2 for 6-12 weeks.

                                      Treatment of thrush infection in the mouth and throat:

                                      • Oral suspension: Each 1 mL of solution contains 40 mg of posaconzole

                                        • Adult and children ages 13 to 17 years old: The typical dose is 100 mg by mouth twice a day on Day 1, followed by 100 mg once a day for 13 days.

                                      Treatment of thrush infection in the mouth and throat not responding to other treatments:

                                      • Oral suspension: Each 1 mL of solution contains 40 mg of posaconzole

                                        • Adults and children ages 13 to 17 years old: The typical dose is 400 mg by mouth twice a day. Your prescriber will determine how long you'll need to take this medication based on your response.

                                      Prevention of serious Candida and Aspergillus infections:

                                      • Delayed-release tablets:

                                        • Adults and children ages 2 to 17 years old (who weigh at least 40 kg): The typical dose is 300 mg by mouth twice a day on Day 1, followed by 300 mg once a day starting on Day 2. Your prescriber will determine how long you'll need to take the medication based on your risk for getting an infection.

                                      • Oral suspension: Each 1 mL of solution contains 40 mg of posaconzole

                                        • Adult and children ages 13 to 17 years old: The typical dose is 200 mg by mouth 3 times a day. Your prescriber will determine how long you'll need to take the medication based on your risk for getting an infection.

                                      • Powder for delayed-release oral suspension: Each packet contains 300 mg of posaconzole

                                        • Children ages 2 to 17 years old (who weigh 10 kg to 40 kg): Your child's prescriber will calculate the dose based on your child's body weight. The dose is usually given twice a day on Day 1, followed by once a day starting on Day 2. Your child's prescriber will determine how long they'll need to take this medication based on their risk of infection.

                                      interactions

                                      Interactions between Posaconazole (Noxafil) and other drugs

                                      Posaconazole (Noxafil) may interact with certain medications or supplements. Always let your doctor and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking. The list below does not include all possible drug interactions with Posaconazole (Noxafil). Please note that only the generic name of each medication is listed below.

                                      Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

                                      Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

                                      Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

                                      drug-cost

                                      How much does Posaconazole (Noxafil) cost?

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                                      contraindications-icon

                                      Posaconazole (Noxafil) contraindications

                                      Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Posaconazole (Noxafil) will not be safe for you to take.
                                      alternatives

                                      What are alternatives to Posaconazole (Noxafil)?

                                      There are a number of medications that your doctor can prescribe in place of Posaconazole (Noxafil). Compare a few possible alternatives below.
                                      Posaconazole (Noxafil)
                                      Used for:

                                      • Prevention of serious fungal infections caused by Candida and Aspergillus

                                      • Treatment of serious Aspergillus infection - tablets only

                                      • Treatment of oral thrush of the mouth and throat - liquid suspension only

                                      $249.98 Lowest GoodRx priceView Prices
                                      Voriconazole (Vfend)
                                      Used for:
                                      $76.70 Lowest GoodRx priceView Prices
                                      Nystatin
                                      Used for:
                                      $6.46 Lowest GoodRx priceView Prices
                                      images

                                      Posaconazole (Noxafil) images

                                      Yellow Oval M And 100 - Posaconazole 100mg Delayed-Release Tablet
                                      This medicine is Yellow, Oval Tablet Imprinted With "100" And "M".Yellow Oval M And 100 - Posaconazole 100mg Delayed-Release Tablet
                                      Yellow Oblong 100 - Posaconazole 100mg Delayed-Release Tablet
                                      This medicine is Yellow, Oblong Tablet Imprinted With "100".Yellow Oblong 100 - Posaconazole 100mg Delayed-Release Tablet
                                      Orange Oblong P11 And H - Posaconazole 100mg Delayed-Release Tablet
                                      This medicine is Orange, Oblong Tablet Imprinted With "P11" And "H".Orange Oblong P11 And H - Posaconazole 100mg Delayed-Release Tablet
                                      Orange Oblong P11 And H - Posaconazole 100mg Delayed-Release Tablet
                                      This medicine is Orange, Oblong Tablet Imprinted With "P11" And "H".Orange Oblong P11 And H - Posaconazole 100mg Delayed-Release Tablet
                                      Yellow Oblong Ac71 - Posaconazole 100mg Delayed-Release Tablet
                                      This medicine is Yellow, Oblong Tablet Imprinted With "Ac71".Yellow Oblong Ac71 - Posaconazole 100mg Delayed-Release Tablet
                                      Yellow Oblong 100 - Posaconazole 100mg Delayed-Release Tablet
                                      This medicine is Yellow, Oblong Tablet Imprinted With "100".Yellow Oblong 100 - Posaconazole 100mg Delayed-Release Tablet
                                      Yellow Oblong 100P - Posaconazole 100mg Delayed-Release Tablet
                                      This medicine is Yellow, Oblong Tablet Imprinted With "100P".Yellow Oblong 100P - Posaconazole 100mg Delayed-Release Tablet
                                      Yellow Oval I3 And 23 - Posaconazole 100mg Delayed-Release Tablet
                                      This medicine is Yellow, Oval Tablet Imprinted With "23" And "I3".Yellow Oval I3 And 23 - Posaconazole 100mg Delayed-Release Tablet

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                                      References

                                      Best studies we found

                                      Adeyinka, A., et al. (2024). Tumor lysis syndrome. StatPearls.

                                      Centers for Disease Control and Prevention. (2024). Aspergillosis basics.

                                      Centers for Disease Control and Prevention. (2024). Risk factors for candidiasis.

                                      View All References (3)

                                      MedlinePlus. (2011). Hereditary fructose intolerance.

                                      MedlinePlus. (2024). Leukoencephalopathy. MedlinePlus.

                                      Merck Sharp & Dohme LLC. (2024). Noxafil- posaconazole suspension; Noxafil- posaconazole tablet, coated; Noxafil- posaconazole solution; Noxafil- posaconazole powder, for suspension [package insert]. DailyMed.

                                      GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.
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