Key takeaways
Mupirocin (Bactroban, Centany) and Polysporin (bacitracin/polymyxin B) are both topical antibiotics used to address skin-related issues, but they have important differences. Mupirocin is specifically used to treat active bacterial skin infections like impetigo and is available by prescription only. It comes in cream and ointment forms and is applied three times a day for up to 10 days. On the other hand, Polysporin is an over-the-counter medication used to prevent infections from minor cuts, scrapes, and burns. It combines two antibiotics and is applied 1 to 3 times daily. While mupirocin is generally well-tolerated, it can cause side effects like headaches and burning at the application site. Polysporin doesn't typically cause side effects when used as directed.
