Compare Metronidazole vs. Fluconazole

Metronidazole (Flagyl) and fluconazole (Diflucan) are both prescription medications used to treat infections, but they belong to different medication classes and treat different types of infections. Metronidazole is a nitroimidazole antibiotic used to treat bacterial and parasitic infections, such as bacterial vaginosis and trichomoniasis. In contrast, fluconazole is an azole antifungal used to treat fungal infections, like vaginal yeast infections and oral thrush. Metronidazole is typically taken multiple times a day, while fluconazole is often taken once daily or as a single dose, depending on the infection. Metronidazole is available as a lower-cost generic and should not be taken with alcohol due to the risk of serious reactions. Fluconazole is also available as a generic and can interact with many medications, including those that affect heart rhythm. Common side effects of metronidazole include nausea and a metallic taste, while fluconazole can cause headache and stomach pain. Both medications have specific warnings regarding use during pregnancy, with metronidazole not recommended in the first trimester and fluconazole generally avoided unless necessary.