Key takeaways
Brexafemme (ibrexafungerp) and Diflucan (fluconazole) are both antifungal medications used to treat vaginal yeast infections. However, they belong to different classes of antifungals: Brexafemme is a triterpenoid antifungal, while Diflucan is an azole antifungal. Brexafemme is taken as 2 tablets twice a day for one day, whereas Diflucan is typically taken as a single 150 mg dose for vaginal yeast infections. Brexafemme is also approved to help lessen recurrent yeast infections, which Diflucan is not. Brexafemme is not safe to use during pregnancy due to potential harm to an unborn baby, and you should use birth control during treatment. Diflucan is generally avoided during pregnancy unless necessary, as it can also pose risks to the unborn baby. Common side effects of Brexafemme include diarrhea, nausea, and stomach pain, while Diflucan can cause headache, nausea, and stomach pain. Additionally, Diflucan has a risk of liver problems and interacts with many medications, so you should avoid alcohol while taking it.
