Expectorant / alpha-1 agonist combinations are used to treat cough and nasal congestion casued by the common cold and other respiratory infections. These medications work by thinning mucus in your airways, making it easier to cough up, and by narrowing blood vessels in your nasal passages to reduce swelling and congestion. They come in different forms, including oral tablets and syrups. Examples include guaifenesin / phenylephrine (Deconex IR) and guaifenesin / pseudoephedrine (Mucinex D). You can choose the form that best fits your needs.