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Acetaminophen Combinations

Acetaminophen is combined with other active ingredients like diphenhydramine and dextromethorphan to relieve cough, cold, allergy, and insomnia symptoms along with treating pain, menstrual pain, and fever.

Why are acetaminophen combinations prescribed?

  1. Pain (30%)
  2. Nasal Congestion (29%)
  3. Allergic Rhinitis (20%)
  4. Cold Symptoms (10%)
  5. Cough (9%)
  6. Migraine (2%)
  7. Insomnia (0%)
  8. Flu (0%)
  9. Allergic Conjunctivitis (0%)
  10. Fever (0%)

Key takeaways

Acetaminophen combinations are used to treat pain, fever, and cold symptoms. They also have other uses, such as managing migraines and sinus pressure. These medications work by combining acetaminophen, which reduces pain and fever, with other active ingredients that target specific symptoms, such as congestion, sleeping difficulties, or inflammation. You can find these medications in different forms, including oral tablets, capsules, and liquid solutions. Examples include acetaminophen / aspirin / caffeine (Excedrin Migraine), acetaminophen / diphenhydramine (Tylenol PM), and acetaminophen / dextromethorphan / doxylamine (NyQuil). These combinations help you manage multiple symptoms with one medication.

Prices for popular Acetaminophen Combinations medications
Viewing 25 of 35 medications
tablet icon

Norel AD

as low as$19
ACETAMINOPHEN; CHLORPHENIRAMINE; PHENYLEPHRINE treats the symptoms of the common cold, allergies, or flu. It works by reducing pain, fever, and red, itchy eyes. It also decreases a runny or stuffy nose. It is a combination of acetaminophen, an antihistamine, and a decongestant.
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Duraflu

as low as$22
ACETAMINOPHEN; DEXTROMETHORPHAN; GUAIFENESIN; PSEUDOEPHEDRINE treats the symptoms of the common cold, allergies, or flu. It works by reducing pain, fever, and cough. It also decreases a runny or stuffy nose and loosens mucus. It is a combination of acetaminophen, a cough suppressant, a decongestant, and an expectorant.
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Excedrin Migraine (acetaminophen / aspirin / caffeine)

as low as$4
ACETAMINOPHEN; ASPIRIN; CAFFEINE treats mild aches and pains. It is a combination of acetaminophen, an NSAID, and caffeine.
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Sudafed PE Pressure and Pain (acetaminophen / phenylephrine)

as low as$4
Sudafed PE Pressure And Pain is part of the Acetaminophen Combinations class and treats Pain, Nasal Congestion and Fever. Acetaminophen is combined with other active ingredients like diphenhydramine and dextromethorphan to relieve cough, cold, allergy, and insomnia symptoms along with treating pain, menstrual pain, and fever. Sudafed PE Pressure And Pain is only available as a brand name drug.
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Tylenol PM (acetaminophen PM, acetaminophen / diphenhydramine)

as low as$4
ACETAMINOPHEN; DIPHENHYDRAMINE treats pain and helps you go to sleep faster. It is a combination of acetaminophen and an antihistamine.
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acetaminophen / chlorpheniramine / dextromethorphan

as low as$4
ACETAMINOPHEN; CHLORPHENIRAMINE; DEXTROMETHORPHAN treats the symptoms of the common cold, allergies, or flu. It works by reducing pain, fever, cough, and red, itchy eyes. It also decreases a runny or stuffy nose. It is a combination of acetaminophen, an antihistamine, and a cough suppressant.
See pricesMore info
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acetaminophen / pamabrom / pyrilamine

as low as$5
ACETAMINOPHEN; PAMABROM; PYRILAMINE relieves menstrual cramps, muscle aches, headaches, fatigue, and bloating. It is a combination of acetaminophen, a diuretic, and an antihistamine.
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Dayquil

as low as$6
Dayquil is part of the Acetaminophen Combinations class and treats Pain, Nasal Congestion, Cough and other conditions. Acetaminophen is combined with other active ingredients like diphenhydramine and dextromethorphan to relieve cough, cold, allergy, and insomnia symptoms along with treating pain, menstrual pain, and fever. Dayquil is only available as a brand name drug.
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bottle-of-oral-liquid icon

Tylenol + Cold + Flu + Cough Night (acetaminophen / dextromethorphan / doxylamine / phenylephrine)

as low as$6
Tylenol + Cold + Flu + Cough Night is part of the Acetaminophen Combinations class and treats Pain, Nasal Congestion, Flu and other conditions. Acetaminophen is combined with other active ingredients like diphenhydramine and dextromethorphan to relieve cough, cold, allergy, and insomnia symptoms along with treating pain, menstrual pain, and fever. Tylenol + Cold + Flu + Cough Night is only available as a brand name drug.
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acetaminophen / guaifenesin / phenylephrine

as low as$6
ACETAMINOPHEN; GUAIFENESIN; PHENYLEPHRINE treats the symptoms of the common cold, allergies, or flu. It works by reducing pain and fever. It also decreases a runny or stuffy nose and loosens mucus. It is a combination of acetaminophen, a decongestant, and an expectorant.
See pricesMore info
bottle-of-oral-solution icon

acetaminophen / dextromethorphan / phenylephrine

as low as$6
Acetaminophen/Dextromethorphan/Phenylephrine is part of the Acetaminophen Combinations class and treats Pain, Cold Symptoms, Cough and other conditions. Acetaminophen is combined with other active ingredients like diphenhydramine and dextromethorphan to relieve cough, cold, allergy, and insomnia symptoms along with treating pain, menstrual pain, and fever. Acetaminophen/Dextromethorphan/Phenylephrine is only available as a generic drug.
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acetaminophen / phenylephrine / dextromethorphan / guaifenesin

as low as$6
ACETAMINOPHEN; DEXTROMETHORPHAN; GUAIFENESIN; PHENYLEPHRINE treats the symptoms of the common cold, allergies, or flu. It works by reducing pain, fever, and cough. It also decreases a runny or stuffy nose and loosens mucus. It is a combination of acetaminophen, a cough suppressant, a decongestant, and an expectorant.
See pricesMore info
tablet icon

acetaminophen / chlorpheniramine / dextromethorphan / phenylephrine

as low as$6
ACETAMINOPHEN; CHLORPHENIRAMINE; DEXTROMETHORPHAN; PHENYLEPHRINE treats the symptoms of the common cold, allergies, or flu. It works by reducing pain, fever, cough, and red, itchy eyes. It also decreases a runny or stuffy nose. It is a combination of acetaminophen, an antihistamine, a cough suppressant, and a decongestant.
See pricesMore info
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Midol Complete (acetaminophen / caffeine / pyrilamine)

as low as$6
Midol Complete is part of the Acetaminophen Combinations class and treats Menstrual Pain. Acetaminophen is combined with other active ingredients like diphenhydramine and dextromethorphan to relieve cough, cold, allergy, and insomnia symptoms along with treating pain, menstrual pain, and fever. Midol Complete is only available as a brand name drug.
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Mucinex Fast Max Cold and Flu

as low as$6
Mucinex Fast Max Cold and Flu is part of the Acetaminophen Combinations class and treats Flu and Cold Symptoms. Acetaminophen is combined with other active ingredients like diphenhydramine and dextromethorphan to relieve cough, cold, allergy, and insomnia symptoms along with treating pain, menstrual pain, and fever. Mucinex Fast Max Cold and Flu is only available as a brand name drug.
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bottle-of-oral-solution icon

Nyquil (acetaminophen / dextromethorphan / doxylamine)

as low as$6
ACETAMINOPHEN; DEXTROMETHORPHAN; DOXYLAMINE treats the symptoms of the common cold, allergies, or flu. It works by reducing pain, fever, cough, and red, itchy eyes. It also decreases a runny or stuffy nose. It is a combination of acetaminophen, an antihistamine, and a cough suppressant.
See pricesMore info
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Mapap PM (acetaminophen PM)

as low as$7
Mapap PM is part of the Acetaminophen Combinations class and treats Pain and Insomnia. Acetaminophen is combined with other active ingredients like diphenhydramine and dextromethorphan to relieve cough, cold, allergy, and insomnia symptoms along with treating pain, menstrual pain, and fever. Mapap PM is only available as a brand name drug.
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Mucinex Fast Max Cold Flu and Sore Throat

as low as$7
Mucinex Fast Max Cold Flu and Sore Throat is part of the Acetaminophen Combinations class and treats Flu and Cold Symptoms. Acetaminophen is combined with other active ingredients like diphenhydramine and dextromethorphan to relieve cough, cold, allergy, and insomnia symptoms along with treating pain, menstrual pain, and fever. Mucinex Fast Max Cold Flu and Sore Throat is only available as a brand name drug.
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Mucinex Sinus Max Pressure and Pain

as low as$8
ACETAMINOPHEN; GUAIFENESIN; PHENYLEPHRINE treats the symptoms of the common cold, allergies, or flu. It works by reducing pain and fever. It also decreases a runny or stuffy nose and loosens mucus. It is a combination of acetaminophen, a decongestant, and an expectorant.
See pricesMore info
bottle-of-oral-liquid icon

Robitussin CF

as low as$9
Robitussin CF is part of the Acetaminophen Combinations class and treats Nasal Congestion, Flu, Cold Symptoms and other conditions. Acetaminophen is combined with other active ingredients like diphenhydramine and dextromethorphan to relieve cough, cold, allergy, and insomnia symptoms along with treating pain, menstrual pain, and fever. Robitussin CF is only available as a brand name drug.
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Excedrin Extra Strength

as low as$9
ACETAMINOPHEN; ASPIRIN; CAFFEINE treats mild aches and pains. It is a combination of acetaminophen, an NSAID, and caffeine.
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acetaminophen / phenylephrine / chlorpheniramine

as low as$12
ACETAMINOPHEN; CHLORPHENIRAMINE; PHENYLEPHRINE treats the symptoms of the common cold, allergies, or flu. It works by reducing pain, fever, and red, itchy eyes. It also decreases a runny or stuffy nose. It is a combination of acetaminophen, an antihistamine, and a decongestant.
See pricesMore info
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Tylenol Cold Daytime

as low as$14
ACETAMINOPHEN; DEXTROMETHORPHAN; PHENYLEPHRINE treats the symptoms of the common cold, allergies, or flu. It works by reducing pain, fever, and cough. It also decreases a runny or stuffy nose. It is a combination of acetaminophen, a cough suppressant, and a decongestant.
See pricesMore info
bottle-of-oral-solution icon

Delsym Nighttime

as low as$14
Delsym Nighttime is part of the Acetaminophen Combinations class and treats Cold Symptoms, Cough and Fever. Acetaminophen is combined with other active ingredients like diphenhydramine and dextromethorphan to relieve cough, cold, allergy, and insomnia symptoms along with treating pain, menstrual pain, and fever. Delsym Nighttime is only available as a brand name drug.
See pricesMore info
oral-solution icon

Mucinex Nightshift Cold and Flu

as low as$14
Mucinex Nightshift Cold and Flu is part of the Acetaminophen Combinations class and treats Flu and Cold Symptoms. Acetaminophen is combined with other active ingredients like diphenhydramine and dextromethorphan to relieve cough, cold, allergy, and insomnia symptoms along with treating pain, menstrual pain, and fever. Mucinex Nightshift Cold and Flu is only available as a brand name drug.
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Disclaimer: Popularity is based on total prescriptions for the brand and generic versions of each drug, regardless of the condition being treated. Some drugs are prescribed for multiple conditions.

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