acetaminophen / pamabrom / pyrilamine
Pamprin Multi-Symptom Maximum Strength is an over-the-counter medication that contains acetaminophen (a pain reliever), pamabrom (a diuretic, or water pill), and pyrilamine (an antihistamine). It's used to treat symptoms caused by monthly menstrual periods (e.g., bloating, cramps, aches, pains, extra water weight) in people ages 12 years and older. It's taken by mouth every 6 hours as needed. Side effects include drowsiness, dizziness, and urinating more often.
What is Pamprin Multi-Symptom Maximum Strength?
What is Pamprin Multi-Symptom Maximum Strength used for?
Short-term relief of symptoms from monthly menstrual periods:
- Cramps
- Headache
- Bloating
- Weight gain from too much fluid in the body
- Muscle aches
- Backache
- Irritability
How Pamprin Multi-Symptom Maximum Strength works
Pamprin Multi-Symptom Maximum Strength is a combination of three medications that work together to relieve symptoms caused by menstrual periods.
- Acetaminophen is a pain reliever. It blocks chemicals in your body to help treat pain.
- Pamabrom is a diuretic (water pill) that tells your kidneys to make more urine. This helps remove the extra fluid in your body.
- Pyrilamine is a first-generation antihistamine that blocks a natural substance in your body called histamine. It might help to relieve irritability by making you feel more calm.
Drug facts
More on Pamprin Multi-Symptom Maximum Strength essentials
Side effects of Pamprin Multi-Symptom Maximum Strength
The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.
Common Side Effects
- Sleepiness
- Dizziness
- Dry mouth
- Constipation
- Urinating more often
Pamprin Multi-Symptom Maximum Strength serious side effects
Contact your healthcare provider immediately if you experience any of the following.
- Excessive sleepiness or dizziness
- Liver damage: severe stomach pain, yellowing of the skin or whites of the eyes, nausea, vomiting, loss of appetite
- Accidentally taking too much medication (overdose): not urinating as often, seizures, hallucinations, confusion, vision changes
The following Pamprin Multi-Symptom Maximum Strength side effects have also been reported
Side effects that you should report to your care team as soon as possible:
- Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
- Liver injury—right upper belly pain, loss of appetite, nausea, light-colored stool, dark yellow or brown urine, yellowing skin or eyes, unusual weakness or fatigue
- Redness, blistering, peeling, or loosening of the skin, including inside the mouth
- Sudden eye pain or change in vision such as blurry vision, seeing halos around lights, vision loss
- Trouble passing urine
Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):
- Dizziness
- Drowsiness
- Headache
- Nausea
- Upset stomach
Get your GoodRx coupon
Pros and cons of Pamprin Multi-Symptom Maximum Strength
Pros
- Can treat multiple menstrual period symptoms
- Taken by mouth
- Available over-the-counter
Cons
- Might need to take multiple times a day
- Might not be a good choice for people already taking a water pill
- Can cause sleepiness
Pharmacist tips for Pamprin Multi-Symptom Maximum Strength
- Pamprin Multi-Symptom Maximum Strength can make you sleepy or dizzy during the day, which can affect your ability to focus, think, or react. Don't drive until you know how the medication affects you.
- Pyrilamine in Pamprin Multi-Symptom Maximum Strength can cause dry mouth. If you experience this side effect, try chewing sugar-free gum or sucking on a sugar-free hard candy. If it's really bothersome, contact your primary care provider because you might need a different treatment plan.
- Stop using Pamprin Multi-Symptom Maximum Strength and contact your primary care provider if you experience any of the following: 1) pain worsens or lasts more than 10 days; 2) fever that gets worse or lasts more than 3 days; 3) you have redness or swelling; or 4) you have new symptoms. These might be signs that you need more medical attention.
- It's best to avoid alcohol while taking Pamprin Multi-Symptom Maximum Strength. Drinking alcohol with antihistamines like pyrilamine can worsen side effects, like sleepiness and dizziness. Also, combining alcohol and acetaminophen raises the risk for liver damage.
- Tell your care team about all the medications you're taking, especially if you're taking warfarin (Coumadin) or medications that cause sleepiness. They can make sure Pamprin Multi-Symptom Maximum Strength is safe for you to take.
- Don't start any new medications while you're taking Pamprin Multi-Symptom Maximum Strength without talking to your primary care provider or pharmacist first. In particular, be aware of other medications that have acetaminophen, diuretics (water pills), or antihistamines. Taking these medications with Pamprin Multi-Symptom Maximum Strength can raise your risk of serious side effects, including liver damage and dizziness.
Common questions about Acetaminophen/Pamabrom/Pyrilamine
You might notice relief from certain symptoms, like aches and cramps, within 45 minutes after a dose of Acetaminophen/Pamabrom/Pyrilamine. This timeframe is estimated based on how quickly the individual medications, like acetaminophen, are known to work. Talk with your healthcare team if you're not sure if this medication is working to treat your symptoms.
Yes, you might feel drowsy or sleepy after taking Acetaminophen/Pamabrom/Pyrilamine. This is a typical side effect of pyrilamine, a first-generation antihistamine in the medication. Avoid driving or doing anything that requires concentration until you know how this medication affects you. If you feel too sleepy to get through your day after taking Acetaminophen/Pamabrom/Pyrilamine, try taking your dose only in the evenings. Contact your primary care provider to discuss other options if this medication continues to make you feel too sleepy.
The typical dose of Acetaminophen/Pamabrom/Pyrilamine is 2 caplets by mouth every 6 hours as needed. Each caplet contains 500 mg of acetaminophen, 25 mg of pamabrom, and 15 mg of pyrilamine. Your primary care provider (PCP) might recommend different dosing directions, depending on what other health conditions you have and what other medications you're taking. Ask your healthcare team if you're not sure how much medication you can take and how often you should take it.
Acetaminophen/Pamabrom/Pyrilamine is only meant to treat symptoms of premenstrual syndrome (PMS) (e.g., cramps, headache, extra water weight). If you don't have menstrual periods but experience symptoms similar to PMS, speak with your healthcare team. They can recommend appropriate medications for you to take based on your symptoms.
No, Acetaminophen/Pamabrom/Pyrilamine doesn't have caffeine in it. But there's another medication in the line of Pamprin OTC products called Pamprin Max Pain + Energy that contains 65 mg of caffeine as one of the active ingredients. The purpose of caffeine in this product is to help treat fatigue and bloating.
No, Acetaminophen/Pamabrom/Pyrilamine doesn't contain a non-steroidal anti-inflammatory drug (NSAID). Instead, it contains acetaminophen (Tylenol) as the pain reliever, which isn't an NSAID. Talk with your healthcare team if you have more questions about the medications in Acetaminophen/Pamabrom/Pyrilamine.
Ask your healthcare team if you want to take ibuprofen (Advil, Motrin) along with Acetaminophen/Pamabrom/Pyrilamine. The medications in Acetaminophen/Pamabrom/Pyrilamine (acetaminophen / pamabrom / pyrilamine) don't interact with ibuprofen. But ibuprofen isn't a safe choice for people with certain medical conditions, such as heart or kidney problems. Your care team can recommend appropriate options for you if you need additional pain relief.
How to save using GoodRx
Risks and warnings for Pamprin Multi-Symptom Maximum Strength
Pamprin Multi-Symptom Maximum Strength can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.
Risk of liver damage
- Risk factors: Drinking 3 or more alcoholic beverages a day | Taking other medications containing acetaminophen | Taking too much Pamprin Multi-Symptom Maximum Strength | History of liver problems
Pamprin Multi-Symptom Maximum Strength contains acetaminophen, a pain reliever. Taking too much acetaminophen can cause serious liver damage. The risk is higher for people who drink alcohol regularly while taking this medication. For most adults, the maximum amount of acetaminophen is 3 or 4 grams in a 24-hour period, depending on your healthcare team's instructions.
Speak to your primary care provider before taking Pamprin Multi-Symptom Maximum Strength if you have liver problems because this medication might not be appropriate for you. Signs of liver problems include dark urine, feeling tired, upset stomach or stomach pain, or yellowing of the skin or whites of the eyes. If you notice any of these symptoms, call your primary care provider right away.
Sleepiness
- Risk factors: Drinking alcohol while taking Pamprin Multi-Symptom Maximum Strength | Taking other medications that cause sleepiness
Pamprin Multi-Symptom Maximum Strength can make you very sleepy, which can affect your ability to focus, think, or react. This side effect is more likely to happen or be more intense if you drink alcohol or take other medications that cause sleepiness (e.g., opioids, benzodiazepines, sleep medications) while taking Pamprin Multi-Symptom Maximum Strength. Don't drive or operate machinery until you know how this medication affects you.
Worsening of certain medical conditions
- Risk factors: Liver problems | Glaucoma | Breathing problems (e.g., emphysema, long-term bronchitis) | Urinary conditions
Pamprin Multi-Symptom Maximum Strength isn't an appropriate option for people with certain medical conditions. For example, if you're 65 years or older or taking other medications that make you sleepy, the pyrilamine in this medication can raise your risk for falls and trouble urinating. Another example is that if you're already taking a water pill, the pamabrom in this medication can put you at higher risk of losing too much body fluids. Before starting Pamprin Multi-Symptom Maximum Strength, let your medical team know about what other medications you're taking and what health conditions you have so they can check to see if this medication is a safe choice for you.
Severe skin or severe allergic reactions
Although rare, acetaminophen in Pamprin Multi-Symptom Maximum Strength can cause serious skin reactions, such as rash, blisters, skin reddening, or skin peeling. It's also possible to have an allergic reaction to the medication, including facial swelling and wheezing. If you notice unusual changes in your skin, swelling in the face, or trouble breathing, stop using Pamprin Multi-Symptom Maximum Strength and get medical attention right away.
Accidentally taking too much medication
Pamprin Multi-Symptom Maximum Strength contains an analgesic (acetaminophen), diuretic (pamabrom), and an antihistamine (pyrilamine), which can be in many other OTC and prescription medications. Taking more than one medication containing acetaminophen, a diuretic, and an antihistamine can lead to serious side effects, including liver problems, dehydration, and agitation.
Tell your care team about the medications you're taking before starting Pamprin Multi-Symptom Maximum Strength to make sure it's safe for you. Don't start any new medications while taking Pamprin Multi-Symptom Maximum Strength without talking to your primary care provider or pharmacist. To prevent an accidental overdose, read package labels carefully. If you're not sure if a product has any similar ingredients, ask your pharmacist. If you or your loved one experiences an accidental overdose, get medical help right away or contact a poison control center at 1-800-222-1222.
Pamprin Multi-Symptom Maximum Strength dosage
Tablet| Dosage | Quantity | Price as low as | Price per unit |
|---|---|---|---|
| 500mg/25mg/15mg | 30 tablets | $4.83 | $0.16 |
Typical dosage for Pamprin Multi-Symptom Maximum Strength
Acetaminophen / pamabrom / pyrilamine combinations are made by several manufacturers. Be sure to check the medication box for specific instructions for your product.
Examples include:
Pamprin Multi-Symptom Maximum Strength Each caplet contains 500 mg of acetaminophen, 25 mg of pamabrom, and 15 mg of pyrilamine.
-
Adults and children 12 years and older: The typical dose is 2 caplets by mouth every 6 hours as needed. Don't take more than 8 caplets in a 24-hour period.
-
Children under 12 years old: Ask your child's pediatrician.
Generic acetaminophen / pamabrom / pyrilamine Each caplet contains 500 mg of acetaminophen, 25 mg of pamabrom, and 15 mg of pyrilamine.
-
Adults and children 12 years and older: The typical dose is 2 caplets by mouth every 6 hours as needed. Don't take more than 6 caplets in a 24-hour period.
-
Children under 12 years old: Ask your child's pediatrician.
More on Pamprin Multi-Symptom Maximum Strength dosage
How much does Pamprin Multi-Symptom Maximum Strength cost?
$4.83
Pamprin Multi-Symptom Maximum Strength contraindications
Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Pamprin Multi-Symptom Maximum Strength will not be safe for you to take.
- History of allergy to acetaminophen, pamabrom, or pyrilamine (or another antihistamine)
- Taking other medications containing acetaminophen
What are alternatives to Pamprin Multi-Symptom Maximum Strength?
Short-term relief of symptoms from monthly menstrual periods:
