Acetaminophens are used to relieve mild to moderate pain and reduce fever. They also have other uses, such as easing arthritis pain. Acetaminophens work by blocking the production of certain chemicals in the brain that cause pain and fever. Acetaminophen (Tylenol) is the only medication in its class. But it comes in different dosage forms, including oral tablets, liquid suspensions, and rectal suppositories. This allows you to pick which formulation works best for you.