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Glyxambi vs. Metformin

Glyxambi (empagliflozin / linagliptin) is used to manage blood sugar levels in adults with Type 2 diabetes. It's a combination of 2 medications: empagliflozin (a sodium-glucose co-transporter 2 (SGLT2) inhibitor) and linagliptin (a dipeptidyl peptidase-4 (DPP-4) inhibitor). It lowers blood sugar by getting rid of extra sugar through your urine and helping your body make more insulin. Glyxambi (empagliflozin / linagliptin) is taken by mouth once daily. Some common side effects include urinary tract infections and upper respiratory tract infections.

• Type 2 diabetes in adults (when taken along with nutritious diet and regular exercise)
• Lowers risk of death from heart problems in adults with Type 2 diabetes and heart disease

• Urinary tract infection (11-13%)
• Upper respiratory tract infection (7%)

• Pancreas problems
• Ketoacidosis (too much acid in the blood)
• Low fluids in the body (leading to low blood pressure or dehydration, or kidney problems)
• Low blood sugar with other diabetes medications
• Genital and urinary tract infections
• Serious allergic or skin reactions
• Joint pain
• Leg and foot amputations
• Heart failure

Immediate-release metformin is an oral diabetes medication. It's approved for people 10 years of age and older with Type 2 diabetes. The medication belongs to the drug class called biguanides. It works best to lower blood sugar levels with a diabetes-friendly diet and exercise plan. Immediate-release metformin comes as a tablet and an oral solution. You take this medication by mouth usually two to three times a day. It's recommended to take each dosage with food to help lessen side effects like diarrhea and nausea.

• Type 2 diabetes in people ages 10 years and older

• Diarrhea (53%)
• Nausea or vomiting (26%)
• Gas (12%)
• Weakness (9%)

• Lactic acidosis
• Low vitamin B12 levels
• Low blood sugar (hypoglycemia) when taken with certain other diabetes medications