Skyrizi vs. Stelara for Plaque Psoriasis and Psoriatic Arthritis: Important Differences and Potential Risks.

Skyrizi

(risankizumab)

Stelara

(ustekinumab)

Summary for Skyrizi

Prescription only

Skyrizi (risankizumab or risankizumab-rzaa) is an injectable medication for many inflammatory conditions. It treats plaque psoriasis in adults and children ages 6 years and up. It can also treat psoriatic arthritis, Crohn's disease, and ulcerative colitis in adults. This medication works as an interleukin antagonist to help lower inflammation. After a few starter doses, it's given every 2 or 3 months, depending on the condition being treated. Side effects include a higher risk of infection.

Indications for Skyrizi

Moderate-to-severe plaque psoriasis in adults and children ages 6 years and older
Psoriatic arthritis in adults
Moderate-to-severe Crohn's disease in adults
Moderate-to-severe ulcerative colitis in adults

Pros and Cons for Skyrizi

Pros

Given every 2 or 3 months after the starter doses (depends on your condition)
Can give maintenance doses at home as injections under the skin after proper training
Approved for children as young as 6 years old with plaque psoriasis

Cons

Must be given as an injection
Can raise the risk of infection
Might take several weeks to months to work fully

Common Side Effects for Skyrizi

Upper respiratory infections (13%)
Headache (4%)
Tiredness (3%)

Warnings for Skyrizi

Allergic reaction
Risk of infection
Rare case of liver injury
Caution when getting vaccines

Summary for Stelara

Prescription only

Stelara (ustekinumab) is an injectable medication used to treat autoimmune conditions like plaque psoriasis, psoriatic arthritis, Crohn's disease, and ulcerative colitis. As an interleukin antagonist, it works by blocking certain proteins that cause inflammation in your body, which helps reduce swelling and ease symptoms. You typically get it as an injection under your skin. Common side effects include common cold symptoms, headache, and feeling tired. This medication also has many biosimilars available.

Indications for Stelara

Moderate-to-severe plaque psoriasis (Ps) - adults and children 6 years and older
Psoriatic arthritis (PsA) - adults and children 6 years and older
Moderate-to-severe Crohn's disease (CD) - adults only
Moderate-to-severe ulcerative colitis (UC) - adults only

Pros and Cons for Stelara

Pros

After the first few doses, only need a shot every 8 to 12 weeks
Available as a prefilled syringe or vial
Syringes can be stored at room temperature for up to 30 days
Approved for children as young as 6 years old

Cons

Can weaken your immune system and raise your risk of infection
Potential to cause serious allergic reactions
For CD and UC, the first dose must be given as an IV infusion
Can't receive live vaccines while taking this medication

Common Side Effects for Stelara

Plaque psoriasis

Common cold symptoms (7-8%)
Upper respiratory tract infection (4-5%)
Headache (5%)

Psoriatic arthritis

Joint pain (3%)
Nausea (3%)

Crohn's disease

Common cold symptoms (11%)
Redness at the injection site (5%)
Yeast infection (5%)
Bronchitis (5%)

Ulcerative colitis:

Common cold symptoms (24%)
Headache (10%)
Stomach pain (7%)
Flu infection (6%)
Fever (5%)

Warnings for Stelara

Infections
Cancers
Severe allergic reaction
Brain condition
Vaccines
Lung problems

Prices with our coupons for Skyrizi vs. Stelara

Skyrizi1 package / 1 pen of 150mg/ml

$20,217.99-

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Ustekinumab1 syringe / 1ml of 90mg/ml

$7,002.73$10,953.51

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Skyrizi vs. Stelara

Skyrizi

Stelara

Summary for Skyrizi

Indications for Skyrizi

Pros and Cons for Skyrizi

Pros

Cons

Common Side Effects for Skyrizi

Warnings for Skyrizi

Summary for Stelara

Indications for Stelara

Pros and Cons for Stelara

Pros

Cons

Common Side Effects for Stelara

Warnings for Stelara

Prices with our coupons for Skyrizi vs. Stelara

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Skyrizi

Stelara

Summary for Skyrizi

Indications for Skyrizi

Pros and Cons for Skyrizi

Pros

Cons

Common Side Effects for Skyrizi

Warnings for Skyrizi

Summary for Stelara

Indications for Stelara

Pros and Cons for Stelara

Pros

Cons

Common Side Effects for Stelara

Warnings for Stelara