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Trintellix Coupon - Trintellix 10mg tablet

Trintellix

vortioxetine
Used for Depression

Trintellix, the brand name for vortioxetine, belongs to a drug class called atypical antidepressants. It's used to treat depression in adults. This medication comes as a tablet that you take by mouth once a day. Common side effects include nausea, diarrhea, and dry mouth. Sexual side effects can also happen, but it's usually less likely than with some other antidepressants. As of 2025, there's no generic version of Trintellix (vortioxetine) available yet.

Reviewed by:
reviewerKristianne Hannemann, PharmD
reviewerCydnee Ng, PharmD
Last reviewed on July 21, 2025
basics-icon

What is Trintellix (vortioxetine)?

What is Trintellix (vortioxetine) used for?

How Trintellix (vortioxetine) works

Trintellix (vortioxetine) is an atypical antidepressant. It's not fully understood how the medication works. But researchers think it helps boost serotonin in your brain. Serotonin is a chemical in the brain that plays a role in regulating mood and emotion.

When does Trintellix (vortioxetine) start working?Time passed since treatment started:
HOURS
DAYS
WEEKS
Initial effect
MONTHS
Full effect

Drug facts

Common BrandsTrintellix
Drug ClassAtypical antidepressant
Controlled Substance ClassificationNot a controlled medication
Generic StatusNo lower-cost generic available
AvailabilityPrescription only
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Side effects of Trintellix (vortioxetine)

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Nausea (21-32%)
  • Diarrhea (7-10%)
  • Dizziness (6-9%)
  • Dry mouth (6-8%)
  • Vomiting (3-6%)
  • Constipation (3-6%)

Less Common Side Effects

Trintellix (vortioxetine) serious side effects

Contact your healthcare provider immediately if you experience any of the following.

  • Suicidal thoughts and behavior
  • Serotonin syndrome: fast heart rate, sweating, muscle stiffness or spasms, fever, confusion
  • Very low sodium: nausea, vomiting, headache, memory problems, confusion, muscle weakness or cramps, low blood pressure
  • Serious bleeding: dizziness, pale skin, feeling weak, getting nosebleeds often, bleeding that's hard to stop, bruising that won't go away, vomiting blood, black and tarry stool
When do Trintellix (vortioxetine) possible side effects begin and end?
Time passed since treatment started:
H
D
W
M
Nausea or vomiting
Dizziness
Dry mouth
Diarrhea
Risk of suicidal thoughts
Seek immediate medical care if you experience this side effect.
If a line continues to the right, you'll likely keep experiencing this side effect once it starts.

Source: DailyMed

The following Trintellix (vortioxetine) side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Incidence not known

Agitation

blood in the stool or urine

confusion

cough

decreased urine output

diarrhea

difficulty swallowing

dizziness

fast or irregular heartbeat

fever

headache

hives, itching

hostility

increased sweating

increased thirst

irritability

large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs

muscle pain or cramps

nausea or vomiting

nose bleeds

overactive reflexes

poor coordination

puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue

red or purple spots on the skin

restlessness

seizures

shivering

sweating

swelling of the breasts or unusual milk production

swelling of the face, ankles, or hands

talking or acting with excitement you cannot control

tightness in the chest

trembling or shaking

trouble breathing

twitching

unusual bleeding or bruising

unusual tiredness or weakness

vomiting blood

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Difficulty having a bowel movement (stool)

dry mouth

Less common

Abnormal ejaculation

bloated or full feeling

decreased sexual performance or desire

excess air or gas in the stomach or intestines

itching skin

passing gas

unusual dreams

Incidence not known

Acid or sour stomach

belching

blurred vision

change in taste

dizziness or lightheadedness

eye pain

feeling of constant movement of self or surroundings

feeling of warmth

heartburn

indigestion

loss of taste

redness of the face, neck, arms, and occasionally, upper chest

sensation of spinning

stomach discomfort, upset, or pain

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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Pros and cons of Trintellix (vortioxetine)

Pros

Cons

  • Can take up to a month or more before you feel the full effects
  • Not approved for use in children
  • Not approved to treat anxiety
pharmacist-tips-icon

Pharmacist tips for Trintellix (vortioxetine)

pharmacist
  • You can take Trintellix (vortioxetine) with or without food. Food won't affect how well it works for you.
  • Set an alarm to help you remember to take Trintellix (vortioxetine) at the same time every day.
  • You should swallow the Trintellix (vortioxetine) tablet whole. It usually isn't a good idea to cut it in half. The tablets aren't scored, so cutting them can give you uneven halves and make you take the wrong dose. Talk to your prescriber if you want to take a lower dose of Trintellix (vortioxetine).
  • Nausea is a common side effect of Trintellix (vortioxetine) during the first week you take it. Most times, you should feel better over the next few weeks. If the nausea doesn't go away, tell your prescriber so they can help you manage this side effect.
  • It's best to avoid drinking alcohol while taking Trintellix (vortioxetine). It can make side effects like dizziness and nausea worse. Talk to a healthcare professional if you have questions about whether it's safe to drink while taking an antidepressant.
  • Don't stop taking Trintellix (vortioxetine) suddenly. Otherwise, it can cause withdrawal symptoms, like dizziness, anxiety, headache, and trouble sleeping. Talk to your prescriber if you want to stop the medication. They can lower the dose slowly over time before you stop completely. This helps lower your risk of withdrawal.
  • Trintellix (vortioxetine) used to have a different brand name, Brintellix. The manufacturer changed its brand name because it sounded too much like the blood thinner Brilinta (ticagrelor). The name change helped lower the risk of getting the two medications mixed up.
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Risks and warnings for Trintellix (vortioxetine)

Trintellix (vortioxetine) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

Suicidal thoughts or behavior

  • Risk factors: Age 24 years or younger | First starting Trintellix (vortioxetine) or when the dose changes

Black Box WarningTrintellix (vortioxetine) may increase your risk of suicidal thoughts or behavior, especially in people under the age of 25. Watch out for worsening depression or any unusual changes in your mood or behavior, especially during the first few months of treatment or with a dose change. Talk to a healthcare professional if you experience any of these symptoms, and seek urgent care if needed.

Serotonin syndrome

  • Risk factors: Taking other medications that raise serotonin levels in the brain

Trintellix (vortioxetine) can cause a very serious and dangerous problem called serotonin syndrome. This happens when you have too much serotonin in your brain.

Your risk is higher if you take Trintellix (vortioxetine) with other medications that also make your serotonin go up. They can include other antidepressants, some opioid pain medications, and triptans for migraine. That's why it's important to tell your care team about all the medications you take. They can check if you're at risk for serotonin syndrome.

Stop taking Trintellix (vortioxetine) and get medical help right away if you have signs of serotonin syndrome. Look out for fever, a lot of sweating, fast heart rate, muscle stiffness or spasms, and confusion.

Higher risk of bleeding

  • Risk factors: Taking blood thinners or other medications that make bleeding or bruising easier

Trintellix (vortioxetine) can raise the risk that you can bleed more easily. The risk is even higher if you also take medications that have a bleeding risk. These include nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen (Advil) and aspirin. It also includes blood thinners like warfarin (Coumadin).

Tell your prescriber and pharmacist about your medications while taking Trintellix (vortioxetine). They can check your bleeding risk. Get medical help right away if you have bleeding that's hard to stop, bruising that doesn't go away, vomit blood, or have black and tarry stool. These might be signs of a serious bleed.

Not for use alone for bipolar disorder

  • Risk factors: Personal or family history of bipolar disorder, mania, or hypomania

Giving someone with bipolar disorder an antidepressant like Trintellix (vortioxetine) by itself can sometimes make them have a manic episode. They can have lots of energy, become very talkative, have racing thoughts, and do risky things. In studies, manic signs were rare with Trintellix (vortioxetine).

Before you start Trintellix (vortioxetine), it's important to tell your prescriber if you or someone in your family has bipolar disorder. Your prescriber will also check if you have this problem or if you're at risk of having it. If so, they'll make sure you get the right help.

Withdrawal symptoms

  • Risk factors: Stopping Trintellix (vortioxetine) too suddenly

Don't stop taking Trintellix (vortioxetine) all of a sudden without talking to your prescriber. Stopping it too quickly could make you have withdrawal symptoms. You could feel nauseous, sweat a lot, feel dizzy, have headaches, and have trouble sleeping.

If you want to stop taking Trintellix (vortioxetine), tell your prescriber first. They can help you stop safely by lowering your dose over time before you stop completely.

Worsening of glaucoma in certain people

  • Risk factors: History of angle-closure glaucoma

Antidepressants such as Trintellix (vortioxetine) can sometimes cause glaucoma to get worse for some people. Tell your prescriber if you have narrow-angle eyes or angle-closure glaucoma and haven't had laser eye surgery.

Call your eye specialist right away if you suddenly have blurry vision, severe eye pain, or see rings of light around lights. These could be signs of a serious eye problem called an angle-closure attack.

Low sodium levels

  • Risk factors: Older age | Taking diuretic medications

Trintellix (vortioxetine) can sometimes make you have low sodium levels in your blood. Watch out for signs like headaches, trouble focusing, feeling confused or weak, or being unsteady on your feet. This can lead to falls. Stop taking this medication and talk to your prescriber right away if this happens. Get urgent care if needed.

Sexual side effects

Trintellix (vortioxetine) might cause problems with sex for both males and females. These problems can include trouble with ejaculation or erectile dysfunction. It can also include not wanting to have sex as much or trouble having an orgasm.

If you notice changes in your sex life that worry you while taking Trintellix (vortioxetine), let your prescriber know. They can check if something else is causing these problems and find ways to help you feel better.

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Trintellix (vortioxetine) dosage

The average cost for 30 tablets of 10mg of Trintellix (vortioxetine) is $10.00 with a free GoodRx coupon. This is 98.44% off the average retail price of $642.66.
tabletTablet
DosageQuantityPrice as low asPrice per unit
5mg30 tablets$10.00$0.33
10mg30 tablets$10.00$0.33
20mg30 tablets$10.00$0.33

Typical dosage for Trintellix (vortioxetine)

The typical starting dose is 10 mg by mouth once daily. The maximum dose is 20 mg by mouth per day.

Your prescriber can adjust the dose based on how well Trintellix (vortioxetine) is working and if you have side effects. They'll also adjust the dose if you take certain interacting medications.

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Interactions between Trintellix (vortioxetine) and other drugs

Trintellix (vortioxetine) may interact with certain medications or supplements. Always let your doctor and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking. The list below does not include all possible drug interactions with Trintellix (vortioxetine). Please note that only the generic name of each medication is listed below.

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

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How much does Trintellix (vortioxetine) cost?

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Trintellix (vortioxetine) contraindications

Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Trintellix (vortioxetine) will not be safe for you to take.

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What are alternatives to Trintellix (vortioxetine)?

There are a number of medications that your doctor can prescribe in place of Trintellix (vortioxetine). Compare a few possible alternatives below.
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News about Trintellix (vortioxetine)

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Trintellix (vortioxetine) images

Yellow Oval 10 And Tl - Trintellix 10mg Tablet
This medicine is Yellow, Oval Tablet Imprinted With "Tl" And "10".Yellow Oval 10 And Tl - Trintellix 10mg Tablet

References

Best studies we found

Alam, M. Y., et al. (2014). Safety, tolerability, and efficacy of vortioxetine (Lu AA21004) in major depressive disorder: Results of an open-label, flexible-dose, 52-week extension study. International Clinical Psychopharmacology.

Hu, X. H., et al. (2004). Incidence and duration of side effects and those rated as bothersome with selective serotonin reuptake inhibitor treatment for depression: Patient reported versus physician estimate. Journal of Clinical Psychiatry.

Khazaeni, B., et al. (2023). Acute angle-closure glaucoma. StatPearls.

GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.