Trintellix Dosages for Adults: Your GoodRx Guide

If you’re living with depression, finding the right medication and dosage to manage your symptoms can make all the difference. Trintellix (vortioxetine) is a treatment option for adults with depression. But what doses are available, and what’s the best way to take it? Here, we’ll review the recommended Trintellix dosages and the best way to get the most from your medication.

What’s the typical Trintellix dosage for adults?

Trintellix is FDA approved for depression in adults. The recommended starting dosage is 10 mg by mouth once daily. Your healthcare provider may slowly increase your dosage up to a maximum of 20 mg daily if needed for your symptoms. They may also lower your dose to 5 mg daily if you’re unable to tolerate the 10 mg dose due to side effects.

You can take Trintellix with or without food. But taking it with food may help lessen nausea, a common side effect of this medication. It’s recommended to take Trintellix at around the same time every day for the best results.

Promotion disclosure

credit_cardSponsored copay cardSubject to eligibility

Trintellix

Avg retail price

$619.32(Save 98.39%)

Copay card

$10.00

See all discounts

How it works

Use GoodRx to find medications, pharmacies, and discounts.

GoodRx discounts can help you pay less for your prescription.

Bring your free coupon or savings card to the pharmacy.

Trintellix comes in 5 mg (pink), 10 mg (yellow), and 20 mg (red) tablets.

Are there any dosage adjustments for medical conditions?

Many medications require a change in dose if you have kidney or liver problems. But Trintellix isn’t affected by these conditions. However, you may need a different Trintellix dosage if you’re taking a medication that interacts with it.

Some medications can lower Trintellix levels in the body. Examples include common antidepressants, such as bupropion (Wellbutrin SR, Wellbutrin XL) and fluoxetine (Prozac). It also includes terbinafine (Lamisil) and quinidine. A lower maximum Trintellix dosage of 10 mg daily is recommended if you take one of these medications. If you’re already taking Trintellix when you start one of these medications, it’s recommended to cut your Trintellix dosage in half.

Other medications have the opposite effect — they can increase Trintellix levels in the body if they’re combined. Examples include rifampin (Rafadin), carbamazepine (Tegretol), and phenytoin (Dilantin). You may need a higher Trintellix dosage if you take it along with one of these medications. But the Trintellix dosage shouldn’t go higher than 3 times the original dose. If you stop taking the interacting medication, your Trintellix dosage should be lowered within 14 days.

Keep in mind: You shouldn’t make changes to your Trintellix dosage on your own. Instead, be sure to discuss your current medication list with your healthcare provider or pharmacist to make sure there aren’t any interactions with Trintellix. And get your provider’s OK before making any changes to the medications you take, in case they may affect Trintellix. 

What happens if you miss a dose of Trintellix?

If you miss a dose of Trintellix by mistake, it’s not likely to cause an issue. Just take it as soon as you remember. If it’s almost time for your next dose, skip the one you missed — don’t take 2 doses at once.

If you’re taking 15 mg or more of Trintellix daily and you miss several doses in a row, you may notice side effects such as a headache or tense muscles. You may also notice a return of your depression symptoms. This may be uncomfortable, but it’s not likely to be dangerous. Talk to your provider about how to get back on track if you’ve missed several doses of Trintellix in a row.

If you’re having trouble remembering to take Trintellix every day, consider using a pill box, medication reminder app, or daily alarm to help.

What should you do if you take too much Trintellix?

As with a missed dose, if you take an extra dose of Trintellix by mistake, it’s not likely to cause a serious problem. You may notice more side effects, such as nausea, dizziness, or diarrhea. Other possible symptoms include itching, fatigue, and red, flushed skin.

Large doses of Trintellix can be more serious. Too much Trintellix can lead to seizures and serotonin syndrome. Serotonin syndrome happens when serotonin levels in the body are too high. Symptoms include sweating, confusion, and muscle spasms.

If you or a loved one takes more Trintellix than prescribed, contact your healthcare provider or call Poison Control at 1-800-222-1222. But if you have any of the serious symptoms described above, call 911 or seek emergency care right away. 

How to save on Trintellix

There are ways to save on Trintellix, which is only available as a brand-name medication. GoodRx can help you navigate between patient assistance programs and copay savings cards to save money on your prescription.

• Save with a copay savings card. If you have commercial insurance, you may be eligible to pay as little as $10 for a 90-day supply of Trintellix using a savings card from the manufacturer.

• Save with patient assistance programs. If you’re uninsured or underinsured, you may be eligible for Trintellix’s patient assistance program, which offers the medication free of cost.

Why trust our experts?

Written by:

Stacia Woodcock, PharmD

Stacia Woodcock, PharmD, is a pharmacy editor for GoodRx. She earned her Doctor of Pharmacy degree from the University of Kentucky and is licensed in New York and Massachusetts.

Reviewed by:

Daphne Berryhill, RPh

Daphne Berryhill, RPh, has two decades of experience as a clinical pharmacist. She spent most of her career in the Chicago area practicing in-home infusion.

Our editorial standards

Meet our experts