Key takeaways:
Trintellix (vortioxetine) is an FDA-approved medication used to treat depression in adults. Without insurance, a 30-day supply of Trintellix 10 mg tablets averages $619.36.
Most insurance plans cover Trintellix, with many requiring prior authorization or step therapy. If you have commercial insurance and meet other requirements, you may pay as little as $10 for a 30- or 90-day prescription with the Trintellix Savings Card.
Those who qualify for the manufacturer’s patient assistance program may receive Trintellix at no cost. If you don’t qualify, GoodRx can help you access Trintellix at an exclusive cash price of $299.
Save on related medications
Trintellix (vortioxetine) is a prescription medication that is FDA-approved to treat depression in adults. It belongs to a class of medications known as atypical antidepressants, and it’s thought to work by increasing the effects of serotonin, a chemical in your body that helps regulate mood, memory, and other functions.
Trintellix is available as an oral tablet and is taken once daily. Your prescriber will typically start you with a 10 mg daily dose. If you tolerate it well, the dose can be gradually increased to 20 mg per day or dropped to 5 mg if needed.
No generic form of Trintellix is available as of 2025, and a 30-day supply can cost several hundred dollars out of pocket. But you can reduce your cost with a GoodRx coupon. You might even receive the medication for free through the manufacturer’s patient assistance program if you qualify.
How much does Trintellix cost?
The manufacturer’s list price for a 30-day supply of Trintellix is around $514 (as of January 2025). But the retail price may be higher due to pharmacy and wholesaler markups.
Without insurance or discounts, 30 tablets of Trintellix 10 mg costs about $619.36. What you pay for the medication can vary widely depending on the pharmacy you choose, your insurance coverage, and other factors.
The table below lists the average retail price for different doses of Trintellix at some pharmacies:
Brand-name Trintellix quantity and form | Dose | Average retail price |
|---|---|---|
30 tablets | 5 mg | |
30 tablets | 10 mg | |
30 tablets | 20 mg |
What factors affect the cost of Trintellix?
Several factors can affect how much you’ll pay for Trintellix, including:
Where you live: Prescription medication prices can vary by location. GoodRx research shows that people in cities such as Denver and Atlanta, for example, often pay less for prescriptions than those in New Orleans and Little Rock-Pine Bluff, Arkansas.
Pharmacy: Different pharmacies in the same neighborhood might charge different prices for the same medications.
Insurance: Most insurance plans cover Trintellix. But you may still have financial responsibilities, including deductibles, copays, or coinsurance.
Discounts: What you pay for Trintellix can be reduced if you use the manufacturer’s copay card, a patient assistance program, or coupons from services including GoodRx.
Does insurance cover Trintellix?
Most Affordable Care Act (ACA, also known as Obamacare) marketplace plans cover Trintellix. But a large majority of enrollees must try other medications first (a process called step therapy), and some ACA plans require prior authorization.
Nearly all people with commercial insurance plans have coverage for Trintellix. But roughly half of covered enrollees must undergo step therapy.
Medicare covers Trintellix for all enrollees. Some Medicare beneficiaries will need prior authorization, and step therapy is required for about one-third. Almost everyone enrolled in Medicaid has coverage for Trintellix, but there’s a high likelihood that prior authorization will be needed. And many Medicaid enrollees face step therapy rules.
Check your health plan’s formulary (its list of covered medications) or contact your insurer to see if Trintellix is covered and what requirements you must meet before getting approval.
Looking for ways to save on prescription medications? These tips can help keep your out-of-pocket prescription costs down.
Make the most of your HSA funds. Here’s how to use your health savings account (HSA) to help cover the cost of Trintellix and other eligible expenses.
Trintellix may cause nausea, dizziness, and constipation. Read about other possible Trintellix side effects to watch for and tips for how to manage them.
How different insurance plans cover Trintellix
The table below shows how likely you are to have coverage for Trintellix and whether you’ll need prior authorization or step therapy, depending on your insurance plan type.
Insurance type | Enrollees covered for Trintellix 10 mg tablets | Enrollees required to get prior authorization | Enrollees required to do step therapy |
|---|---|---|---|
83.7% | 36.3% | 67.9% | |
Commercial plans (excluding ACA plans) | 95.3% | 16.0% | 49.6% |
Medicare (original Medicare and Medicare Advantage plans) | 100.0% | 19.4% | 31.3% |
Medicaid, including state-run and managed care plans | 99.9% | 64.4% | 40.1% |
Source: Managed Markets Insight & Technology, LLC™, as of April 14, 2025. (See methodology below.)
If your insurance doesn’t cover Trintellix, try the following:
See if you qualify for financial help through Help At Hand — the manufacturer’s patient assistance program — or the Trintellix Savings Card (more details below).
Talk to your prescriber about other antidepressants that may work for you. Some alternatives may be covered by your plan or have lower out-of-pocket costs.
Request a formulary exception to get Trintellix covered. Your prescriber may need to submit supporting documentation and a letter of medical necessity explaining why you need this specific medication. If the exception request is denied, you can file an appeal.
During open enrollment, review and compare health plans. Switching to one that covers the medications you need could reduce your costs.
Ways to save on Trintellix
Trintellix can cost hundreds of dollars per month if you’re paying out of pocket. But there are ways to reduce these expenses or even get the medication for free. Here are six strategies to help you save on Trintellix:
1. Use a free GoodRx coupon
Anyone with a valid prescription, regardless of insurance status, can use GoodRx to purchase a 30-day supply of Trintellix at an exclusive cash price of $299.
How to get your coupon:
Visit www.goodrx.com or download the GoodRx app.
Search for “Trintellix” and tap “Find the lowest prices.”
Choose your prescribed dose and quantity.
Print your coupon, or have it sent to you via text or email. If you’re using the app, have the coupon ready on your phone’s screen.
Show the coupon at the pharmacy when dropping off your prescription. This helps avoid delays and ensures you get the discounted price.
2. Check if you qualify for the Help At Hand patient assistance program
If you’re eligible for the manufacturer’s patient assistance program, you may receive Trintellix at no cost. Takeda, the manufacturer of Trintellix, offers this program to help people who have no insurance or insufficient coverage and can’t afford to pay out of pocket.
To qualify, you must:
Live in the U.S. or a U.S. territory
Have a valid prescription from a licensed U.S. healthcare professional
Meet income requirements based on your household size
If approved, you can receive Trintellix at no cost for up to 1 year. You’ll need to reapply to the program before your eligibility ends if you still need financial support.
3. See if you’re eligible for the manufacturer’s savings card
You may pay as little as $10 for a 30- or 90-day prescription with the Trintellix Savings Card. This card offers up to $100 off each 30-day prescription or $300 off each 90-day prescription, with maximum total savings of $1,300 per year.
To qualify, you must:
Be 18 years or older with a valid Trintellix prescription
Have commercial insurance that doesn’t fully cover the cost of the medication
Not be enrolled in any state pharmaceutical assistance programs or government-funded health programs, such as Medicare, Medicaid, or Tricare
Not have insurance that is paying the entire cost of the prescription
4. Compare prices at different pharmacies
The retail price for medications can vary quite a bit between pharmacies, even ones just down the street from each other.
Before picking up your Trintellix prescription, check around for the best pharmacy prices. You can do this by calling a few local pharmacies. Or you can quickly and easily compare prices online by using www.goodrx.com to avoid overpaying.
5. Look into a 90-day supply
Some insurance plans offer reduced copays when you get a 3-month supply instead of filling your prescription monthly. If this applies to your plan, talk to your prescriber about switching to a 90-day supply of Trintellix. Many pharmacies also provide discounts for larger quantities, which can be helpful if you’re paying cash.
You might also find better pricing for 90-day supplies through your plan’s mail-order pharmacy. This option is convenient, since medications are delivered right to your home. A healthcare professional will likely need to prescribe the larger quantity to help you take advantage of these savings.
6. Tap into your tax-advantaged health funds
It’s easy to overlook your health savings account (HSA) or flexible spending account (FSA) when picking up your prescriptions. But these tax-free funds can be used toward many healthcare expenses, including the cost of Trintellix. You can use your HSA or FSA card at the pharmacy counter, or hang onto the receipt and submit it for reimbursement.
FSA funds usually expire at the end of the plan year, so be sure to use them in time. HSA funds, on the other hand, roll over annually and remain available whenever you need them.
Frequently asked questions
No, there’s no generic version of Trintellix available as of August 2025.
If your insurance doesn’t cover Trintellix, check if you qualify for the manufacturer’s patient assistance program or savings card. You can also ask your prescriber about other covered antidepressants that might work for you, request a formulary exception from your insurance, or consider switching to a different insurance plan during open enrollment.
Other atypical antidepressants, such as bupropion (Wellbutrin), may cost less than Trintellix out of pocket. Plus, health plans may offer better coverage for this and other generic alternatives.
No, there’s no generic version of Trintellix available as of August 2025.
If your insurance doesn’t cover Trintellix, check if you qualify for the manufacturer’s patient assistance program or savings card. You can also ask your prescriber about other covered antidepressants that might work for you, request a formulary exception from your insurance, or consider switching to a different insurance plan during open enrollment.
Other atypical antidepressants, such as bupropion (Wellbutrin), may cost less than Trintellix out of pocket. Plus, health plans may offer better coverage for this and other generic alternatives.
The bottom line
Without insurance, 30 tablets of Trintellix (vortioxetine) 10 mg costs about $619.36. But what you pay for the medication can vary based on your pharmacy, location, and insurance plan.
If you have commercial insurance, you may be eligible for the Trintellix Savings Card, which can bring your cost down to $10 per prescription fill. If you’re uninsured or underinsured and meet income requirements, the manufacturer’s patient assistance program may offer the medication at no cost.
Other ways to save on Trintellix include using a free GoodRx coupon and comparing prices at different pharmacies. You can also reduce your out-of-pocket costs for Trintellix by switching to 90-day supplies or using your tax-free dollars.
Why trust our experts?
Methodology
We obtained national prescription coverage data for each medication from Managed Markets Insight & Technology (MMIT). The data reflects health insurance coverage as of April 2025.
We calculated the percentage of enrollees in plans that cover each medication by dividing the number of enrollees covered for the medication within a specific insurance channel (e.g., ACA, Medicare, Medicaid) by the total number of enrollees in all plans within that channel.
We determined the percentage of enrollees in plans with a prior authorization requirement by calculating the proportion of enrollees in plans that required prior authorization for the medication within each channel.
Finally, we measured the percentage of enrollees in plans with a step therapy requirement by calculating the proportion of enrollees in plans that imposed step therapy requirements for the medication in each channel.
These estimates, derived from national MMIT coverage data, provide insight into health insurance coverage for each medication. They take into account restrictions such as prior authorization, step therapy, and quantity limits. The percentages are expressed relative to the total number of enrollees covered by various insurance channels, including ACA plans, commercial (excluding ACA) plans, Medicare, and Medicaid (both state-run and managed care plans).
References
HealthCare.gov. (n.d.). Appealing a health plan decision. U.S. Centers for Medicare & Medicaid Services.
Help At Hand. (n.d.). About the program. Takeda Pharmaceutical.
Medicaid.gov. (n.d.). Managed care. U.S. Centers for Medicare & Medicaid Services.
Trintellix. (n.d.). Get started with a savings card. Takeda Pharmaceuticals.
