sumatriptan / naproxen
Treximet helps treat migraine in people age 12 years and older. It's a tablet that has two main ingredients: sumatriptan and naproxen. Sumatriptan is a triptan, and naproxen is a nonsteroidal anti-inflammatory drug (NSAID). These ingredients work together to treat migraine symptoms. Treximet is taken by mouth at the first sign of a migraine. Side effects aren't common but can include dizziness, sleepiness, and nausea. Treximet is available as a brand-name and generic medication.
What is Treximet?
What is Treximet used for?
Treatment of migraine attacks with or without aura in people age 12 years and older
How Treximet works
Treximet is a combination of two ingredients that work together to treat migraine headaches.
Sumatriptan is a triptan. It works by attaching to serotonin receptors in the brain. It lessens blood vessel swelling in the brain, which is thought to help with migraine pain. Sumatriptan also stops other pain signals from releasing through the nervous system.
Naproxen is a nonsteroidal anti-inflammatory drug (NSAID). It blocks a protein in the body called cyclooxygenase (COX) that causes pain and swelling. This helps relieve migraine pain.
Drug Facts
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What are the side effects of Treximet?
Common Side Effects
- Dizziness (4%)
- Sleepiness (3%)
- Nausea (3%)
- Chest pain or discomfort (3%)
- Pain, tightness, or pressure in the neck, throat, or jaw (3%)
- "Pins and needles" feeling (2%)
- Indigestion (2%)
- Dry mouth (2%)
- Feeling hot all of a sudden, flushed (up to 2%)
- Muscle tightness (up to 2%)
Other Side Effects
Serious Side Effects
- Stomach bleeding: feeling faint, vomiting blood, bloody or dark stools, severe stomach pain or discomfort
- Heart attack: chest pain or tightness that spreads up to your shoulder, arm, neck, or jaw; difficulty breathing; sweating
- Stroke: severe headache, weakness in one part of your body or face, slurred speech, blurred vision, confusion
- Heart failure: difficulty breathing, swelling, sudden weight gain, tiredness, dizziness
- Irregular heart rhythm (arrhythmia): slow heartbeat, skipped heartbeats, pounding in the chest, a fluttering feeling in the chest, chest pain, dizziness, weakness, trouble breathing
- Narrowing of blood vessels in the body: bloody diarrhea; severe stomach pain; partial or permanent blindness; tightness, weakness, numbness of legs or feet
- Serotonin syndrome: fast heart rate, sweating, flushing, tremor (shakiness), muscle stiffness or twitching, uncoordinated movement, hallucinations
- Liver problems: swelling of your stomach, yellowing of your skin or the whites of your eyes, confusion, dark or brown urine
- Kidney problems: tiredness, dry and itchy skin, urinating less than usual, foamy or bloody urine, muscle cramps
- Serious allergic reaction: hives; rash; swelling of the face, lips, or tongue; difficulty breathing
- Serious skin reaction: skin redness, blisters, rash
- Seizure
Source: DailyMed
More on Treximet side effects
The following side effects have also been reported
Side effects that you should report to your care team as soon as possible:
- Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
- Bleeding—bloody or black, tar-like stools, vomiting blood or brown material that looks like coffee grounds, red or dark brown urine, small red or purple spots on skin, unusual bruising or bleeding
- Burning, pain, tingling, or color changes in the hands, arms, legs, or feet
- Heart attack—pain or tightness in the chest, shoulders, arms, or jaw, nausea, shortness of breath, cold or clammy skin, feeling faint or lightheaded
- Heart failure—shortness of breath, swelling of the ankles, feet, or hands, sudden weight gain, unusual weakness or fatigue
- Heart rhythm changes—fast or irregular heartbeat, dizziness, feeling faint or lightheaded, chest pain, trouble breathing
- High potassium level—muscle weakness, fast or irregular heartbeat
- Increase in blood pressure
- Irritability, confusion, fast or irregular heartbeat, muscle stiffness, twitching muscles, sweating, high fever, seizure, chills, vomiting, diarrhea, which may be signs of serotonin syndrome
- Kidney injury—decrease in the amount of urine, swelling of the ankles, hands, or feet
- Liver injury—right upper belly pain, loss of appetite, nausea, light-colored stool, dark yellow or brown urine, yellowing skin or eyes, unusual weakness or fatigue
- Low red blood cell level—unusual weakness or fatigue, dizziness, headache, trouble breathing
- Rash, fever, and swollen lymph nodes
- Raynaud syndrome—cool, numb, or painful fingers or toes that may change color from pale, to blue, to red
- Redness, blistering, peeling, or loosening of the skin, including inside the mouth
- Round red or dark patches on the skin that may itch, burn, and blister
- Seizures
- Stroke—sudden numbness or weakness of the face, arm, or leg, trouble speaking, confusion, trouble walking, loss of balance or coordination, dizziness, severe headache, change in vision
- Sudden or severe stomach pain, bloody diarrhea, fever, nausea, vomiting
- Vision loss
Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):
- Dizziness
- Fatigue
- Headache
- Loss of appetite
- Nausea
- Upset stomach
Pros and cons of Treximet
Pros
Combines two first-choice options for treating migraines into one pill for convenience
Okay for children as young as 12 years old to take
Can take with or without food
Cons
Not for preventing migraines from happening
Migraines can get worse if you take this medication too often
Not the best option for people who are taking certain antidepressants or for people who have asthma, certain heart conditions, or serious liver problems
Pharmacist tips for Treximet
You can take Treximet with or without food. Be sure to swallow the tablets whole with water. Don't split, crush, or chew the tablet because it can affect how well the medication works. Talk to your prescriber if you have trouble swallowing the tablet.
For adults: Take Treximet at the first sign of a migraine. If your migraine comes back or if it doesn't relieve your symptoms, you can take one more dose of Treximet. Wait at least 2 hours after your first dose to take another. Talk to your prescriber for more options if your migraine doesn't get better after two doses of the medication. Don't take Treximet to treat an average of more than 5 migraines within a 30-day period.
For children age 12 to 17 years old: Take Treximet as soon as the migraine starts. Children can only take Treximet once per day since it isn't known if taking the medication more than once in the same day is safe and works well. Ask a healthcare professional about what to do if the migraine doesn't go away or comes back. Don't take Treximet to treat an average of more than 2 migraines within a 30-day period.
Keep track of how often you take migraine medications, including Treximet. Try not to take migraine medications more than 9 days in a month. You could get rebound headaches (also called medication-overuse headaches). It can lead to more migraine-like headaches or more migraine attacks. If you get migraines often, talk to your prescriber about other ways to manage them.
You might feel tightness, pressure, or pain in the chest, throat, jaw, or neck after you take Treximet. These symptoms typically don't last long (up to an hour) and usually go away. But keep in mind that they can be a lot like signs of a heart attack or other heart problems. Get medical help right away if these symptoms are worsening, don't go away, or worry you.
Get medical help as soon as possible if you have severe stomach pain, have bloody or dark stools, or vomit blood. Treximet raises the risk of stomach bleeding, which needs to get treated right away.
Limit the amount of alcohol you drink or avoid alcohol while you're taking Treximet. Alcohol can raise your risk for stomach bleeding, other stomach-related side effects, dizziness, and sleepiness. It can also trigger more migraines.
Don't take Treximet at the same time as other NSAIDs, such as ibuprofen (Motrin, Advil). Treximet contains an NSAID. And taking more than one NSAID at the same time raises your risk for stomach bleeds, stroke, and heart attack. Keep in mind NSAIDs are common in over-the-counter pain and cold medications. Talk with a pharmacist if you're not sure whether you're already taking an NSAID.
If you're taking low-dose aspirin for your heart, ask your primary care provider if it's safe for you to also take Treximet. Taking both medications together raises your risk for side effects.
Let your healthcare team and pharmacist know about all the other medications you're taking (including vitamins and supplements). Treximet contains naproxen and sumatriptan, and both ingredients have many drug interactions that can lead to harmful side effects. Your care team can help check that all your medications are safe to take together.
Frequently asked questions about Treximet
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What are the risks and warnings for Treximet?
Treximet can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.
Risk for stomach ulcers and stomach bleeding
Risk factors: Older adults | History of peptic ulcer disease | History of stomach bleeding | Bleeding problems | Severe liver problems | Drinking alcohol | Smoking | Poor overall health | Taking other medications that raise your risk of bleeds (e.g., NSAIDs, blood thinners) | Taking Treximet for a long time
Treximet contains naproxen, which is an NSAID. NSAIDs can raise the risk for stomach problems, like inflammation, stomach ulcers (sores), and bleeding. These serious problems can happen at any time while you're taking Treximet. They're serious problems that should get treated as soon as possible.
Tell your prescriber and pharmacist about your health conditions and any other medications you take. They can help check your risk for stomach ulcers and stomach bleeding.
Let your prescriber know if you have symptoms of a stomach ulcer, like burning stomach pain that doesn't go away, burning feeling in the chest, acid reflux, nausea, vomiting, or feeling full too quickly. For stomach bleeds, people often don't have any symptoms. But you should get emergency help if you feel faint, vomit blood, or have bloody or dark stools.
Risk for heart attack, chest pain (angina), and stroke
Risk factors: Heart problems | Taking higher doses of Treximet | Taking Treximet for a long time | Past or planned heart surgery | Taking multiple NSAIDs
Treximet might raise your risk of blood clots, which can lead to a heart attack or stroke. Some people also had chest pain (angina) after taking Treximet. Talk to your prescriber about your health conditions before taking Treximet so they can check your risk for these problems. Don't take Treximet if you've had or will have heart surgery because your risk is much higher after surgery.
To lower your risk, take the lowest dose of Treximet for the shortest time needed for migraine. Don't take other NSAIDs with Treximet. Call 911 right away if you have signs of a heart attack like chest pain that spreads to the arm, neck, or jaw; shortness of breath; sweating; or nausea. Also get medical help right away if you have symptoms of a stroke, like weakness on one side of your body, a drooping face, or trouble speaking or walking.
High blood pressure, swelling, and risk for heart failure
Risk factors: High blood pressure | Heart failure
NSAIDs like the naproxen in Treximet can cause your body to hold onto extra fluid. This might raise your blood pressure and also cause swelling in the legs or feet. Fluid buildup can also put you at risk for heart failure. Let your prescriber know about your medical history and the medications you take so they can check your risk for these problems.
Call your primary care provider if your blood pressure stays higher than usual while you're taking Treximet. Also let them know if you have any swelling in the legs or ankles or other signs of heart failure, like difficulty breathing, sudden weight gain, tiredness, dizziness, or chest pain with physical activity.
Irregular heart rhythm (arrhythmias)
Some people who've taken a triptan, like the sumatriptan in Treximet, have had serious heart rhythm problems (arrhythmia). This can happen within a few hours after taking the medication. Don't take Treximet if you have a condition that causes arrhythmia. Tell your prescriber if you have a slow heartbeat, a fluttering or pounding heart, chest pain, dizziness, weakness, or trouble breathing. These can be signs of an arrhythmia.
Extreme narrowing of blood vessels
Sumatriptan, an ingredient in Treximet, can cause the blood vessels in certain areas of your body to become very narrow. This can prevent certain parts of your body from getting enough blood, which can lead to problems.
For example, it can sometimes cause symptoms similar to Raynaud's phenomenon. This can appear as color changes in your hands and feet (can turn pale or more reddish depending on how much blood is flowing through). Other times, the blood vessels in the stomach can narrow and cause stomach pain or bloody diarrhea. And although rare, narrowing of the blood vessels in the eye can cause vision problems.
Let your prescriber know if you have any of these symptoms. Don't take any more Treximet until your prescriber checks that it's safe for you.
Serotonin syndrome
Risk factors: Taking other medications that raise serotonin levels
Some people who take Treximet can get a rare but serious condition called serotonin syndrome. This happens when there's too much serotonin in the brain. The risk is higher if you take Treximet with other medications that can raise your serotonin levels, like some antidepressants. Tell your prescriber about all the medications you take so they can check your risk.
Symptoms of serotonin syndrome include fever, sweating, shivering, fast heartbeat, muscle stiffness or spasms, and confusion. These symptoms can start within minutes to hours after starting a new medication that raises your serotonin levels. They can also happen when you switch to a higher dose of these medications. Get medical help right away if you have any symptoms of serotonin syndrome.
Liver damage
Some people who take NSAIDs, including the naproxen in Treximet, can have higher liver enzyme levels in their blood. This could be a sign of liver problems. In rare cases, these problems have led to liver failure. Don't take Treximet if you have severe liver problems.
Call your prescriber right away if you have nausea; diarrhea; upper right-sided stomach pain; yellowing of your skin or the whites of your eyes; stool changes (black, tarry, or bloody stools); or itchy skin. These could be signs of liver damage. Your care team might need to check your liver and might tell you to stop taking Treximet.
Kidney damage
Risk factors: Age 65 or older | Kidney problems | Liver problems | Heart failure | Dehydration | Taking other medications that can cause kidney damage (e.g., diuretics, ACE inhibitors, ARBs)
Taking NSAIDs (like the naproxen in Treximet) for a long time can harm your kidneys. Your risk is higher if you're an older adult or have certain health issues like kidney problems or heart failure. The risk is also higher if you take other medications that can cause kidney damage. Call your prescriber if you notice any signs of kidney damage. They can include changes in how often you need to urinate, tiredness, dry and itchy skin, and muscle cramps.
Severe allergic reactions and skin reactions
Risk factors: Aspirin allergy | NSAID allergy
Treximet can cause serious and sometimes life-threatening allergic reactions. They can include swelling of the face, shock, and a severe reaction called anaphylaxis. Tell your prescriber if you're allergic to aspirin or other NSAIDs. Since Treximet has an NSAID in it, you might be at risk of having an allergic reaction to the medication. Get medical help right away if you have hives; rash; swelling of your face, lips, or tongue; or trouble breathing after taking Treximet.
Although rare, the naproxen in Treximet can cause serious skin reactions. They can include Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and drug reaction with eosinophilia and systemic symptoms (DRESS). Stop taking Treximet and get medical care right away if you notice unusual changes in your skin, such as rash, blisters, or peeling skin.
Avoid during pregnancy because of risk of harm to an unborn baby
Treximet contains naproxen. Naproxen can cause harm to an unborn baby, especially if it's taken in the second half of pregnancy (after week 20). It can cause serious problems for your baby, like issues with the heart, kidney, or other organs.
Speak to your prescriber or obstetrician-gynecologist (OB-GYN) about the risks and benefits of taking Treximet if you're pregnant. Ask whether there are safer options for relieving your migraine.
Treximet dosage forms
| Dosage | Quantity | Price as low as | Price per unit |
|---|---|---|---|
| 85mg/500mg | 9 tablets | $1247.85 | $138.65 |
Typical dosing for Treximet
Each Treximet tablet contains 85 mg of sumatriptan and 500 mg of naproxen.
Age 18 years and older: The typical dose is 1 tablet by mouth as a single dose for migraine. If your migraine comes back or doesn't completely go away, you can take another tablet at least 2 hours later. Don't take more than 2 Treximet tablets in a day.
Age 12 to 17 years old: The typical dose is 1 tablet by mouth as a single dose for migraine. If the migraine comes back or doesn't fully go away, talk to your child's pediatrician about what to do. The most your child can take in one day is 1 Treximet tablet.
Your dose will differ if you have liver problems.
How much does Treximet cost?
Treximet contraindications
Previous allergic reaction to sumatriptan or naproxen
History of asthma, hives, or other allergic reactions after taking aspirin or another NSAID
Right before or after coronary artery bypass graft surgery (CABG), a type of open heart surgery
Uncontrolled high blood pressure
Coronary artery disease (CAD)
Certain conditions that cause an irregular heart rhythm (arrhythmia), such as Wolff-Parkinson White syndrome
History of stroke or transient ischemic attack ("mini-stroke")
History of hemiplegic or basilar migraine
Severe liver problems
Have taken an ergot-containing or ergot-type medications like dihydroergotamine (Migranal) in the last 24 hours
Have taken a different triptans in the last 24 hours
Currently take or have taken a monoamine oxidase inhibitor (MAOI), such as selegiline, in the last 14 days
What are alternatives to Treximet?
Treatment of migraine attacks with or without aura in people age 12 years and older
Treatment of migraine attacks with or without aura in adults
Treatment of migraine attacks with or without aura in adults
What is the latest news about Treximet?
Treximet images
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References
Best studies we foundAilani, J., et al. (2021). The American Headache Society Consensus Statement: Update on integrating new migraine treatments into clinical practice. Headache.
American Heart Association. (2025). Prinzmetal angina.
Currax Pharmaceuticals LLC. (2024). Treximet- sumatriptan succinate and naproxen sodium tablet, film coated [package insert]. DailyMed.
Feuerstadt, P. (2019). Small bowel ischemia. American College of Gastroenterology.
Kadian, R., et al. (2023). Basilar migraine. StatPearls.
Kumar, A., et al. (2023). Hemiplegic migraine. StatPearls.
MedlinePlus. (2024). Wolff-Parkinson-White syndrome (WPW).
National Heart, Lung, and Blood Institute. (2022). What is coronary artery bypass grafting?
National Kidney Foundation. (2020). 10 signs you may have kidney disease.
NorthStar RxLLC. (2025). Sumatriptan and naproxen sodium tablet, film coated [package insert]. DailyMed.
Preuss, C. V., et al. (2023). Prescription of controlled substances: Benefits and risks. StatPearls.
Swarup, S., et al. (2023). Coronary artery vasospasm. StatPearls.
U.S. Food and Drug Administration. (2022). FDA recommends avoiding use of NSAIDs in pregnancy at 20 weeks or later because they can result in low amniotic fluid.
Visser, W. H., et al. (1996). Chest symptoms after sumatriptan: A two-year clinical practice review in 735 consecutive migraine patients. Cephalalgia.
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