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Compare Skyrizi vs. Humira

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Skyrizi (risankizumab) and Humira (adalimumab) are both injectable medications used to treat inflammatory conditions, but they work differently and have different uses. Skyrizi is an interleukin antagonist that targets IL-23 to reduce inflammation and is used for plaque psoriasis, psoriatic arthritis, and Crohn's disease in adults. Humira, on the other hand, is a biologic DMARD that blocks TNF, another protein involved in inflammation, and is used for a wider range of conditions, including rheumatoid arthritis, juvenile idiopathic arthritis, Crohn's disease, ulcerative colitis, and more. Skyrizi is typically administered every 2 to 3 months after initial doses, while Humira is usually given every other week. Skyrizi is only available as a brand-name medication, whereas Humira has several biosimilars. Both medications can increase the risk of infections, but Humira also has warnings for potential cancer risks and nervous system effects. Skyrizi is not approved for use in children, while Humira can be used in young children for certain conditions.

  • Skyrizi (risankizumab)
    Humira (adalimumab)
  • Skyrizi (risankizumab)
    Humira (adalimumab)

  • Summary of Skyrizi vs. Humira

    Summary for Interleukin antagonist
    Prescription only

    Skyrizi (risankizumab or risankizumab-rzaa) is an injection used to treat different inflammatory conditions in adults. This includes plaque psoriasis, psoriatic arthritis, Crohn's disease, and ulcerative colitis. It belongs to the drug class called interleukin antagonists. It works to lower inflammation and relieve symptoms. After the first few doses, you usually get the Skyrizi (risankizumab) injection every 2 or 3 months. This medication can raise your risk of infection as a side effect.

    Summary for TNF blocker
    Prescription only

    Humira (adalimumab) is an injection used to treat many different autoimmune conditions like rheumatoid arthritis, Crohn's disease, ulcerative colitis, and plaque psoriasis. As a TNF blocker, the medication works by blocking a protein that causes inflammation in your body. It's given as a shot under the skin once every 1 to 2 weeks, depending on your condition. Humira (adalimumab) doesn't have a true generic, but there are several similar versions called biosimilars. Common side effects include infections, injection site reactions, and headache.

  • Indications of Skyrizi vs. Humira

    Indications for
    •Moderate-to-severe plaque psoriasis in adults
    •Psoriatic arthritis in adults
    •Moderate-to-severe Crohn's disease in adults
    •Moderate-to-severe ulcerative colitis in adults
    Indications for
    •Rheumatoid arthritis (RA) - adults only
    •Juvenile idiopathic arthritis (JIA) - people age 2 and older
    •Psoriatic arthritis (PsA) - adults only
    •Ankylosing spondylitis (AS) - adults only
    •Crohn's disease (CD) - people age 6 and older
    •Ulcerative colitis (UC) - people age 5 and older
    •Plaque psoriasis - adults only
    •Hidradenitis suppurativa (HS) - people age 12 and older
    •Uveitis - people age 2 and older

  • Pros and Cons of Skyrizi vs. Humira

    Pros and Const for Interleukin antagonist
    Pros
    •Given every 2 or 3 months after a couple of starter doses (depends on your condition)
    •Can give injections under the skin at home after you get trained
    Cons
    •Must be given as an injection
    •Not approved for children
    Pros and Const for TNF blocker
    Pros
    •Can be used for many autoimmune conditions
    •Available as a ready-to-use pen that makes it easier to self-inject at home
    •Can be used in young children (as young as 2 years old for some conditions)
    •Only needs to be injected a couple times a month
    •Can be left at room temperature for up to 14 days if needed
    Cons
    •Raises the risk of serious infections
    •Can take a few weeks or longer to work
    •Might be difficult to inject for some people
    •Can't receive any live vaccines while taking the medication
    •Might contain rubber or latex, which can cause a reaction for those with an allergy

  • Common Side Effects of Skyrizi vs. Humira

    Common Side Effects for
    •Upper respiratory infections (13%)
    •Headache (4%)
    •Tiredness (3%)
    Common Side Effects for
    •Injection-site reaction (20%)
    •Upper respiratory tract infection (17%)
    •Headache (12%)
    •Rash (12%)
    •Sinus inflammation (11%)
    •Accidental injury (10%)
    •Nausea (9%)
    •Urinary tract infection (UTI) or bladder infection (8%)

    Note: The side effects listed above were reported by adults with rheumatoid arthritis and are similar to those seen in people using Humira (adalimumab) for other conditions.

  • Warnings of Skyrizi vs. Humira

    Common Side Effects for
    •Allergic reaction
    •Risk of infection
    •Rare case of liver injury
    •Caution when getting vaccines
    Common Side Effects for
    •Serious infections
    •Cancers
    •Severe allergic reactions
    •Nervous system effects
    •Low blood cell counts
    •Heart failure
    •Lupus-like syndrome
    •Live vaccines

  • Prices with our coupons for Skyrizi vs. Humira

    Learn more about Skyrizi
    Learn more about Humira

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