Key takeaways
Rebif (interferon beta-1a) and Tecfidera (dimethyl fumarate) are both used to treat relapsing forms of multiple sclerosis (MS), but they have some key differences. Rebif is an injectable biologic that you need to inject under the skin three times a week, while Tecfidera is an oral medication taken as capsules twice a day. Rebif can cause flu-like symptoms and injection site reactions, whereas Tecfidera commonly causes indigestion and flushing. Tecfidera is available as a lower-cost generic, but Rebif does not have a generic form. Both medications can lower your white blood cell count and affect your liver, so regular blood tests are needed. Additionally, Rebif might not be suitable for people with a history of mental health conditions, while Tecfidera can cause serious allergic reactions and stomach problems.
