Key takeaways
Prezista (darunavir) and Viracept (nelfinavir) are both protease inhibitors used to treat HIV, but they have some key differences. Prezista (darunavir) is typically taken once a day with a booster like ritonavir (Norvir) and food, while Viracept (nelfinavir) is taken two to three times a day with meals. Prezista (darunavir) is available as an oral tablet or suspension, making it easier for those who have trouble swallowing pills, whereas Viracept (nelfinavir) offers tablets that can be dissolved in water and an oral powder. Prezista (darunavir) is safe to take during pregnancy, but Viracept (nelfinavir) has limited reports suggesting potential risks for birth defects and liver problems. Additionally, Prezista (darunavir) must be used cautiously in people with sulfa allergies, while Viracept (nelfinavir) should be avoided in those with moderate or severe liver problems. Both medications interact with many other medications, but Viracept (nelfinavir) has a higher frequency of causing diarrhea, especially in children.
