Key takeaways
Prezista (darunavir) and Aptivus (tipranavir) are both protease inhibitors used to treat HIV, but they have some key differences. Prezista (darunavir) is often preferred because it is taken once a day and is available as an oral suspension, making it easier to use. In contrast, Aptivus (tipranavir) requires multiple capsules daily and must be taken twice a day, which can be less convenient. Prezista (darunavir) is generally safe during pregnancy, while Aptivus (tipranavir) is not commonly used due to its side effects and interactions with other medications. Both medications need to be taken with a booster like ritonavir (Norvir) to work effectively. However, Aptivus (tipranavir) has a higher risk of causing liver problems, bleeding in the brain, and raising cholesterol and blood sugar levels. Additionally, both medications should be used cautiously if you have a sulfa allergy.
