Glyxambi vs. Metaglip for Diabetes Type 2: Important Differences and Potential Risks.

Glyxambi

(empagliflozin / linagliptin)

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Glipizide/metformin

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Summary for Glyxambi

Prescription only

Glyxambi (empagliflozin / linagliptin) is a medication that helps manage blood sugar in adults with Type 2 diabetes. It works best when used with a balanced diet and exercise. It can also help lower the risk of heart-related death in adults with both Type 2 diabetes and heart disease. Glyxambi combines two diabetes medications into one tablet. They belong to the sodium-glucose co-transporter 2 (SGLT2) inhibitor and a dipeptidyl peptidase-4 (DPP-4) inhibitor drug classes. Glyxambi is taken by mouth once every morning. Side effects can include urinary tract infections and upper respiratory tract infections.

Indications for Glyxambi

Type 2 diabetes in adults
Lowering the risk of death due to heart problems in adults with Type 2 diabetes and heart disease

Pros and Cons for Glyxambi

Pros

Combines two diabetes medications into one pill
Taken once a day in the morning, with or without food
Less likely to cause low blood sugar when taken by itself

Cons

Might cause more urination
Can raise the risk of urinary tract infections or genital yeast infections
Not approved for people with Type 1 diabetes

Common Side Effects for Glyxambi

Urinary tract infection (11-13%)
Upper respiratory tract infection (7%)
Cold symptoms (6-7%)

Warnings for Glyxambi

Inflammation of the pancreas (pancreatitis)
Ketoacidosis (too much acid in the blood)
Low fluids in the body (leading to low blood pressure or dehydration)
Low blood sugar (hypoglycemia) when used with certain other diabetes medications
Genital and urinary tract infections
Leg and foot amputations
Serious allergic reactions
Severe skin reaction
Severe joint pain
Risk of heart failure

Summary for Metaglip

Prescription only

Glipizide/metformin combines two diabetes medications into one tablet: glipizide (a sulfonylurea) and metformin (a biguanide). It's approved to treat Type 2 diabetes in adults along with diet and exercise. This medication is typically taken by mouth once or twice a day. Some common side effects of glipizide/metformin can include diarrhea and headache; it isn't likely to cause weight gain or weight loss.

Indications for Metaglip

Type 2 diabetes

Pros and Cons for Metaglip

Pros

Taken by mouth
Combination medication, so more convenient to take
Available as a lower-cost generic

Cons

Need to take with meals
Can't take during pregnancy
Not an option for children

Common Side Effects for Metaglip

Diarrhea (18%)
Headache (13%)
Cold or flu infection (10%)
Low blood sugar levels (9%)
Muscle pain (8%)
Nausea, vomiting (8%)
Stomach pain (6%)
Dizziness (5%)

Warnings for Metaglip

Lactic acidosis
Possible risk of serious heart problems
Low blood sugar levels
Low vitamin B12 levels

Prices with our coupons for Glyxambi vs. Metaglip

Glyxambi30 tablets / 25mg/5mg

$349.04$615.86

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Glipizide/Metformin60 tablets / 5mg/500mg

$20.03$32.93

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Glyxambi vs. Metaglip

Glyxambi

Glipizide/metformin

Summary for Glyxambi

Indications for Glyxambi

Pros and Cons for Glyxambi

Pros

Cons

Common Side Effects for Glyxambi

Warnings for Glyxambi

Summary for Metaglip

Indications for Metaglip

Pros and Cons for Metaglip

Pros

Cons

Common Side Effects for Metaglip

Warnings for Metaglip

Prices with our coupons for Glyxambi vs. Metaglip

Compare other Diabetes Type 2 drugs

Browse medications by letter

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Glyxambi

Glipizide/metformin

Summary for Glyxambi

Indications for Glyxambi

Pros and Cons for Glyxambi

Pros

Cons

Common Side Effects for Glyxambi

Warnings for Glyxambi

Summary for Metaglip

Indications for Metaglip

Pros and Cons for Metaglip

Pros

Cons

Common Side Effects for Metaglip

Warnings for Metaglip