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Gemtesa vs. Tolterodine

Gemtesa (vibegron) is a brand-name medication that's used to treat overactive bladder (OAB) in adults. This includes OAB in people who are taking medications for benign prostatic hyperplasia (BPH). Gemtesa (vibegron) belongs to the drug class called beta-3 adrenergic agonists. The typical dosage is 1 tablet by mouth once per day. Side effects aren't common but can include headache and symptoms of a common cold. There's no generic version available yet.

• Overactive bladder (OAB)
• Overactive bladder in people who are taking medications for benign prostatic hyperplasia (BPH)

• Headache (4%)
• Cold symptoms (3%)
• Diarrhea (2%)
• Nausea (2%)
• Upper respiratory tract infection (2%)

• Angioedema (swelling of face, mouth, throat, or other organ)
• Risk of difficulty emptying the bladder completely

Tolterodine (Detrol) is used to treat overactive bladder (OAB) in adults. It's an anticholinergic medication that helps with bladder control to lessen the need to go to the restroom suddenly or often. The immediate-release tablet (Detrol) is taken by mouth twice a day. There's also an extended-release capsule (Detrol LA) that's taken just once a day. Both formulations come in brand-name and generic-name versions. Tolterodine (Detrol) can commonly cause dry mouth. Other side effects can include headache and constipation.

• Overactive bladder (OAB)

Immediate-release tablets:

• Dry mouth (35%)
• Headache (7%)
• Constipation (7%)
• Stomach pain (5%)
• Dizziness or feeling like you're spinning (5%)

Extended-release capsules:

• Dry mouth (23%)
• Headache (6%)
• Constipation (6%)
• Stomach pain (4%)

• Serious allergic reaction and swelling (angioedema)
• Dizziness and drowsiness
• Caution use in people with narrow-angle glaucoma
• Caution use in people with trouble urinating
• Caution use in people with problems causing gut blockage
• Caution use in people with myasthenia gravis
• Caution use in people with certain heart rhythm problems