Head-to-head comparisons of medication uses, side effects, warnings, and more.
Key takeaways
Tamsulosin (Flomax) and doxazosin (Cardura) are both alpha-1 blockers used to treat benign prostatic hyperplasia (BPH), but they have some differences. Tamsulosin is specifically for BPH and must be taken 30 minutes after the same meal each day, while doxazosin can also treat high blood pressure and is taken once daily, with the extended-release version (Cardura XL) taken with breakfast. Tamsulosin is considered a first-choice treatment for BPH, whereas doxazosin is not a first-choice for high blood pressure. Both medications can cause dizziness and low blood pressure, but tamsulosin is less likely to cause a sudden drop in blood pressure upon standing. Additionally, tamsulosin may affect sexual health, causing abnormal ejaculation, while doxazosin is less likely to cause erectile dysfunction. Both medications are available in lower-cost generic forms.
Tamsulosin
Doxazosin (Cardura)
Tamsulosin
Doxazosin (Cardura)
Summary of Flomax vs. Cardura
Summary for Alpha-1 blocker
Prescription only
Tamsulosin is an alpha-1 blocker used to treat benign prostatic hyperplasia (BPH), also known as enlarged prostate. It works by relaxing the muscles in your prostate and bladder, making it easier to urinate. The medication comes as a capsule that you take once a day, usually 30 minutes after the same meal each day. Side effects include headache, dizziness, and abnormal ejaculation.
Summary for Alpha antagonist
Prescription only
Doxazosin mesylate (Cardura) is an alpha-1 blocker that's used to treat adults with enlarged prostate (benign prostatic hyperplasia, BPH) or high blood pressure. It's also available as brand name Cardura XL, an extended-release tablet that's FDA approved for treating BPH only. The typical dosage is one tablet by mouth once a day. Side effects include low blood pressure, dizziness, and fatigue.