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Compare Gemtesa vs. Tolterodine

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Vibegron (Gemtesa) and tolterodine (Detrol) are both medications used to treat overactive bladder (OAB). However, they belong to different medication classes. Vibegron is a beta-3 adrenergic agonist, while tolterodine is an anticholinergic medication, also known as a urinary antispasmodic. Vibegron is taken as a 75 mg tablet once daily, whereas tolterodine is available in both immediate-release and extended-release forms (Detrol LA), with dosing varying from 1 mg to 4 mg per day. Vibegron is only available as a brand-name medication, while tolterodine is available in both brand-name and generic forms. Common side effects of vibegron include headache and cold symptoms, while tolterodine can cause dry mouth, headache, and dizziness. Vibegron can be taken with anticholinergics, but tolterodine should not be combined with other anticholinergic medications due to increased risk of side effects. Additionally, tolterodine may cause memory problems and is linked to a higher risk of dementia, which is not a significant concern with vibegron.

  • Gemtesa
    Tolterodine (Detrol)
  • Gemtesa
    Tolterodine (Detrol)

  • Summary of Gemtesa vs. Tolterodine

    Summary for Beta-3 adrenergic agonist
    Prescription only

    Gemtesa is a brand-name medication that's used to treat overactive bladder (OAB) in adults. This includes OAB in people who are taking medications for benign prostatic hyperplasia (BPH). Gemtesa belongs to the drug class called beta-3 adrenergic agonists. The typical dosage is 1 tablet by mouth once per day. Side effects aren't common but can include headache and symptoms of a common cold. There's no generic version available yet.

    Summary for Anticholinergic
    Prescription only

    Tolterodine (Detrol) is used to treat overactive bladder (OAB) in adults. It's an anticholinergic medication that helps with bladder control to lessen the need to go to the restroom suddenly or often. The immediate-release tablet (Detrol) is taken by mouth twice a day. There's also an extended-release capsule (Detrol LA) that's taken just once a day. Both formulations come in brand-name and generic-name versions. Tolterodine (Detrol) can commonly cause dry mouth. Other side effects can include headache and constipation.

  • Indications of Gemtesa vs. Tolterodine

    Indications for
    •Overactive bladder (OAB)
    •Overactive bladder in people who are taking medications for benign prostatic hyperplasia (BPH)
    Indications for
    •Overactive bladder (OAB)

  • Pros and Cons of Gemtesa vs. Tolterodine

    Pros and Const for Beta-3 adrenergic agonist
    Pros
    •A first-choice option for overactive bladder
    •Can take with anticholinergics for OAB, if needed
    •Tablets are crushable if you have trouble swallowing pills
    Cons
    •Can take several weeks to see improvement in your symptoms
    •Not recommended for people with severe liver or kidney problems
    •Hasn't been studied in children
    Pros and Const for Anticholinergic
    Pros
    •Works well to help lessen your urge to urinate
    •Might cause less dry mouth than oxybutynin
    •Also available in an extended-release version that's taken only once a day
    Cons
    •Can cause uncomfortable dry mouth and constipation
    •Can make you feel sleepy or dizzy, which can raise your risk of falls
    •Can't take if you have an allergy to another OAB medication called Toviaz (fesoterodine)

  • Common Side Effects of Gemtesa vs. Tolterodine

    Common Side Effects for
    •Headache (4%)
    •Cold symptoms (3%)
    •Diarrhea (2%)
    •Nausea (2%)
    •Upper respiratory tract infection (2%)
    Common Side Effects for

    Immediate-release tablets:

    •Dry mouth (35%)
    •Headache (7%)
    •Constipation (7%)
    •Stomach pain (5%)
    •Dizziness or feeling like you're spinning (5%)

    Extended-release capsules:

    •Dry mouth (23%)
    •Headache (6%)
    •Constipation (6%)
    •Stomach pain (4%)

  • Warnings of Gemtesa vs. Tolterodine

    Common Side Effects for
    •Angioedema (swelling of face, mouth, throat, or other organ)
    •Risk of difficulty emptying the bladder completely
    Common Side Effects for
    •Serious allergic reaction and swelling (angioedema)
    •Dizziness and drowsiness
    •Caution use in people with narrow-angle glaucoma
    •Caution use in people with trouble urinating
    •Caution use in people with problems causing gut blockage
    •Caution use in people with myasthenia gravis
    •Caution use in people with certain heart rhythm problems

  • Prices with our coupons for Gemtesa vs. Tolterodine

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