Key takeaways
Solifenacin (Vesicare) and tolterodine (Detrol) are both medications used to treat overactive bladder (OAB), but they have some differences. Solifenacin (Vesicare) is an anticholinergic and antimuscarinic medication that relaxes bladder muscles and is taken once daily. It is available in both tablet and liquid forms, with the liquid form being more expensive. Tolterodine (Detrol), on the other hand, is a urinary antispasmodic that also relaxes bladder muscles but comes in immediate-release (IR) and extended-release (ER) forms. The IR form is taken twice a day, while the ER form is taken once a day. Both medications can cause dry mouth and may also be linked to memory issues and dementia with long-term use. Neither medication may be the best option for people over age 65 years due to the risk of dizziness and drowsiness, which can lead to falls. Both medications should be used cautiously if you have certain medical conditions like narrow-angle glaucoma or urinary retention.
