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Compare Enablex vs. Detrol

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Darifenacin ER (fromerly branded as Enablex) and tolterodine (Detrol) are both used to treat overactive bladder (OAB) symptoms, but they have some differences. Darifenacin is only available in an extended-release form, while tolterodine comes in both immediate-release and extended-release forms. This means you can take tolterodine either once or twice a day, depending on the version, whereas darifenacin is taken once a day. Both medications can cause dry mouth and constipation, but tolterodine might cause less dry mouth compared to darifenacin. Darifenacin is generally not recommended for people 65 or older due to the risk of dizziness and drowsiness, while tolterodine can be used with caution in this age group. Additionally, tolterodine has a known risk of memory problems and a potential link to dementia, which is not mentioned for darifenacin. Both medications are available in lower-cost, generic versions.

  • Darifenacin
    Tolterodine (Detrol)
  • Darifenacin
    Tolterodine (Detrol)

  • Summary of Enablex vs. Detrol

    Summary for Anticholinergic
    Prescription only

    Darifenacin hydrobromide is a medication that treats overactive bladder in adults. It belongs to a drug class called anticholinergics. Darifenacin comes as an extended-release tablet that you take by mouth once a day. Common side effects include dry mouth and constipation. The brand name of the medication, Enablex, has been discontinued. So generic darifenacin is the only version available now.

    Summary for Urinary antispasmodic
    Prescription only

    Tolterodine (Detrol) is used to treat overactive bladder (OAB) symptoms, such as loss of bladder control and the need to go to the restroom suddenly or often. This medication can commonly cause dry mouth, but other side effects can include headache, dizziness, and constipation. There are immediate-release (IR) and extended-release (ER) versions of tolterodine (Detrol). Both formulations are available as brand-name and generic-name medications. Tolterodine (Detrol) can interact with anticholinergics, like diphenhydramine (Benadryl).

  • Indications of Enablex vs. Detrol

    Indications for
    •Overactive bladder (OAB) in adults
    Indications for
    •Overactive bladder (OAB)

  • Pros and Cons of Enablex vs. Detrol

    Pros and Const for Anticholinergic
    Pros
    •Helps lower the urge to urinate and improves bladder control
    •Taken by mouth once per day
    Cons
    •Commonly causes dry mouth, which can be uncomfortable
    •Not the best choice for people with severe liver problems, certain gut problems, or trouble urinating
    Pros and Const for Urinary antispasmodic
    Pros
    •Works well for OAB symptoms by helping you control your urge to urinate
    •Causes less dry mouth than oxybutynin
    •Extended-release version is taken only once a day
    •Available as a lower-cost, generic version
    Cons
    •Can raise your risk for falls because it can make you feel drowsy or dizzy
    •Can cause severe dry mouth and constipation
    •Can't use if you have an allergy to Toviaz (fesoterodine), which is another OAB medication

  • Common Side Effects of Enablex vs. Detrol

    Common Side Effects for
    •Dry mouth (up to 35%)
    •Constipation (up to 21%)
    •Urinary tract infection (5%)
    Common Side Effects for
    •Dry mouth (up to 35%)
    •Headache (up to 7%)
    •Constipation (up to 7%)
    •Stomach pain (up to 5%)
    •Dizziness or feeling like your surroundings are spinning (up to 5%)

  • Warnings of Enablex vs. Detrol

    Common Side Effects for
    •Swelling of the face and possible breathing problems (angioedema)
    •Side effects related to the nervous system
    •Caution in people with blockage in the bladder
    •Caution in people with digestive problems
    •Caution in people with glaucoma
    Common Side Effects for
    •Unusual swelling of the face, lips, or throat (angioedema)
    •Dizziness and drowsiness
    •Vision changes
    •Trouble urinating and stomach problems
    •Possible higher risk of side effects in people with liver and kidney problems
    •Caution use in people with myasthenia gravis
    •Caution use in people with heart rhythm problems

  • Prices with our coupons for Enablex vs. Detrol

    Learn more about Darifenacin
    Learn more about Tolterodine

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