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Compare Enablex vs. Detrol

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Darifenacin ER (fromerly branded as Enablex) and tolterodine (Detrol) are both used to treat overactive bladder (OAB) symptoms, but they have some differences. Darifenacin is only available in an extended-release form, while tolterodine comes in both immediate-release and extended-release forms. This means you can take tolterodine either once or twice a day, depending on the version, whereas darifenacin is taken once a day. Both medications can cause dry mouth and constipation, but tolterodine might cause less dry mouth compared to darifenacin. Darifenacin is generally not recommended for people 65 or older due to the risk of dizziness and drowsiness, while tolterodine can be used with caution in this age group. Additionally, tolterodine has a known risk of memory problems and a potential link to dementia, which is not mentioned for darifenacin. Both medications are available in lower-cost, generic versions.

  • Darifenacin
    Tolterodine (Detrol)
  • Darifenacin
    Tolterodine (Detrol)

  • Summary of Enablex vs. Detrol

    Summary for Anticholinergic
    Prescription only

    Darifenacin hydrobromide is a medication that treats overactive bladder in adults. It belongs to a drug class called anticholinergics. Darifenacin comes as an extended-release tablet that you take by mouth once a day. Common side effects include dry mouth and constipation. The brand name of the medication, Enablex, has been discontinued. So generic darifenacin is the only version available now.

    Summary for Anticholinergic
    Prescription only

    Tolterodine (Detrol) is used to treat overactive bladder (OAB) in adults. It's an anticholinergic medication that helps with bladder control to lessen the need to go to the restroom suddenly or often. The immediate-release tablet (Detrol) is taken by mouth twice a day. There's also an extended-release capsule (Detrol LA) that's taken just once a day. Both formulations come in brand-name and generic-name versions. Tolterodine (Detrol) can commonly cause dry mouth. Other side effects can include headache and constipation.

  • Indications of Enablex vs. Detrol

    Indications for
    •Overactive bladder (OAB) in adults
    Indications for
    •Overactive bladder (OAB)

  • Pros and Cons of Enablex vs. Detrol

    Pros and Const for Anticholinergic
    Pros
    •Helps lower the urge to urinate and improves bladder control
    •Taken by mouth once per day
    Cons
    •Commonly causes dry mouth, which can be uncomfortable
    •Not the best choice for people with severe liver problems, certain gut problems, or trouble urinating
    Pros and Const for Anticholinergic
    Pros
    •Works well to help lessen your urge to urinate
    •Might cause less dry mouth than oxybutynin
    •Also available in an extended-release version that's taken only once a day
    Cons
    •Can cause uncomfortable dry mouth and constipation
    •Can make you feel sleepy or dizzy, which can raise your risk of falls
    •Can't take if you have an allergy to another OAB medication called Toviaz (fesoterodine)

  • Common Side Effects of Enablex vs. Detrol

    Common Side Effects for
    •Dry mouth (up to 35%)
    •Constipation (up to 21%)
    •Urinary tract infection (5%)
    Common Side Effects for

    Immediate-release tablets:

    •Dry mouth (35%)
    •Headache (7%)
    •Constipation (7%)
    •Stomach pain (5%)
    •Dizziness or feeling like you're spinning (5%)

    Extended-release capsules:

    •Dry mouth (23%)
    •Headache (6%)
    •Constipation (6%)
    •Stomach pain (4%)

  • Warnings of Enablex vs. Detrol

    Common Side Effects for
    •Swelling of the face and possible breathing problems (angioedema)
    •Side effects related to the nervous system
    •Caution in people with blockage in the bladder
    •Caution in people with digestive problems
    •Caution in people with glaucoma
    Common Side Effects for
    •Serious allergic reaction and swelling (angioedema)
    •Dizziness and drowsiness
    •Caution use in people with narrow-angle glaucoma
    •Caution use in people with trouble urinating
    •Caution use in people with problems causing gut blockage
    •Caution use in people with myasthenia gravis
    •Caution use in people with certain heart rhythm problems

  • Prices with our coupons for Enablex vs. Detrol

    Learn more about Darifenacin
    Learn more about Tolterodine

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