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Compare Myrbetriq vs. Detrol

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Myrbetriq (mirabegron) and tolterodine (Detrol) are both used to treat overactive bladder (OAB) symptoms, but they work in different ways. Myrbetriq is a beta-3 adrenergic agonist that helps your bladder relax so it can hold more urine, while tolterodine is an anticholinergic medication that blocks certain receptors to relax bladder muscles and control spasms. Myrbetriq is taken once daily and is available only as a brand-name medication, whereas tolterodine comes in both immediate-release and extended-release forms, with generic versions available. Common side effects of Myrbetriq include high blood pressure and urinary tract infections, while tolterodine often causes dry mouth, headache, and dizziness. Myrbetriq might be safer for older adults and causes less drowsiness and constipation compared to other OAB medications, but it can raise blood pressure. Tolterodine can cause severe dry mouth and constipation and may increase the risk of falls due to dizziness or drowsiness.

  • Myrbetriq (mirabegron)
    Tolterodine (Detrol)
  • Myrbetriq (mirabegron)
    Tolterodine (Detrol)

  • Summary of Myrbetriq vs. Detrol

    Summary for Beta-3 adrenergic agonist
    Prescription only

    Myrbetriq (mirabegron) is used to help with overactive bladder (OAB) in adults. It can also treat a bladder problem called neurogenic detrusor overactivity (NDO) in children 3 years and older. It works as a beta-3 adrenergic agonist to help the bladder hold more urine. Myrbetriq (mirabegron) is taken by mouth once a day. It comes as a brand-name or generic extended-release tablet. A solution made from granules of the medication is available for children, but it's brand name only. Side effects include high blood pressure, cold symptoms, and urinary tract infections.

    Summary for Urinary antispasmodic
    Prescription only

    Tolterodine (Detrol) is used to treat overactive bladder (OAB) symptoms, such as loss of bladder control and the need to go to the restroom suddenly or often. This medication can commonly cause dry mouth, but other side effects can include headache, dizziness, and constipation. There are immediate-release (IR) and extended-release (ER) versions of tolterodine (Detrol). Both formulations are available as brand-name and generic-name medications. Tolterodine (Detrol) can interact with anticholinergics, like diphenhydramine (Benadryl).

  • Indications of Myrbetriq vs. Detrol

    Indications for
    •Overactive bladder (OAB) in adults
    •Neurogenic detrusor overactivity (NDO) in children ages 3 years and older
    Indications for
    •Overactive bladder (OAB)

  • Pros and Cons of Myrbetriq vs. Detrol

    Pros and Const for Beta-3 adrenergic agonist
    Pros
    •Helps control sudden urges to urinate, leaks, and needing to go too often
    •Only taken once a day
    •Causes less side effects like dry mouth than anticholinergics for overactive bladder (like oxybutynin)
    •Might be safer for older adults than anticholinergics for overactive bladder
    Cons
    •Might raise your blood pressure
    •Might have trouble fully emptying your bladder if you have a blockage in your bladder or if you also take anticholinergics for bladder control
    •Not recommended if you have severe kidney or liver problems
    Pros and Const for Urinary antispasmodic
    Pros
    •Works well for OAB symptoms by helping you control your urge to urinate
    •Causes less dry mouth than oxybutynin
    •Extended-release version is taken only once a day
    •Available as a lower-cost, generic version
    Cons
    •Can raise your risk for falls because it can make you feel drowsy or dizzy
    •Can cause severe dry mouth and constipation
    •Can't use if you have an allergy to Toviaz (fesoterodine), which is another OAB medication

  • Common Side Effects of Myrbetriq vs. Detrol

    Common Side Effects for

    Adults:

    •High blood pressure (8-11%)
    •Common cold symptoms (4%)
    •Urinary tract infection (3-4%)
    •Headache (2-3%)
    •Constipation (2%)
    •Upper respiratory tract infection (2%)

    Children:

    •Urinary tract infection (24%)
    •Common cold symptoms (6%)
    •Constipation (5%)
    •Headache (4%)
    •Nausea (2%)
    Common Side Effects for
    •Dry mouth (up to 35%)
    •Headache (up to 7%)
    •Constipation (up to 7%)
    •Stomach pain (up to 5%)
    •Dizziness or feeling like your surroundings are spinning (up to 5%)

  • Warnings of Myrbetriq vs. Detrol

    Common Side Effects for
    •High blood pressure
    •Risk of having trouble fully emptying the bladder in certain people
    •Unusual swelling of the face, lips, or throat (angioedema)
    •Interactions with other medications
    Common Side Effects for
    •Unusual swelling of the face, lips, or throat (angioedema)
    •Dizziness and drowsiness
    •Vision changes
    •Trouble urinating and stomach problems
    •Possible higher risk of side effects in people with liver and kidney problems
    •Caution use in people with myasthenia gravis
    •Caution use in people with heart rhythm problems

  • Prices with our coupons for Myrbetriq vs. Detrol

    Learn more about Myrbetriq
    Learn more about Tolterodine

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