Key takeaways
Myrbetriq (mirabegron) and tolterodine (Detrol) are both used to treat overactive bladder (OAB) symptoms, but they work in different ways. Myrbetriq is a beta-3 adrenergic agonist that helps your bladder relax so it can hold more urine, while tolterodine is an anticholinergic medication that blocks certain receptors to relax bladder muscles and control spasms. Myrbetriq is taken once daily and is available only as a brand-name medication, whereas tolterodine comes in both immediate-release and extended-release forms, with generic versions available. Common side effects of Myrbetriq include high blood pressure and urinary tract infections, while tolterodine often causes dry mouth, headache, and dizziness. Myrbetriq might be safer for older adults and causes less drowsiness and constipation compared to other OAB medications, but it can raise blood pressure. Tolterodine can cause severe dry mouth and constipation and may increase the risk of falls due to dizziness or drowsiness.
