Head-to-head comparisons of medication uses, side effects, warnings, and more.
Key takeaways
Darifenacin ER (formerly branded as Enablex) and trospium (formerly branded as Sanctura adn Sanctura XR) are both medications used to treat overactive bladder (OAB), but they have some differences. Darifenacin, a urinary antispasmodic, is taken once a day and works by blocking certain receptors in your bladder to help relax the muscles. Trospium, an antimuscarinic, is available in both immediate-release tablets taken twice daily and extended-release capsules taken once daily. Trospium works by blocking acetylcholine from attaching to receptors in your bladder, which also helps relax the muscles. While both medications can cause dry mouth and constipation, darifenacin has a higher incidence of these side effects. Additionally, darifenacin can cause drowsiness and dizziness, making it less suitable for those 65 or older. Trospium must be taken on an empty stomach, which can be less convenient. Both medications are available in generic forms, making them more affordable options.
Darifenacin
Trospium
Darifenacin
Trospium
Summary of Enablex vs. Sanctura
Summary for Anticholinergic
Prescription only
Darifenacin hydrobromide is a medication that treats overactive bladder in adults. It belongs to a drug class called anticholinergics. Darifenacin comes as an extended-release tablet that you take by mouth once a day. Common side effects include dry mouth and constipation. The brand name of the medication, Enablex, has been discontinued. So generic darifenacin is the only version available now.
Summary for Antimuscarinic
Prescription only
Trospium chloride is an antimuscarinic medication that's used to treat overactive bladder in adults. It's available as an immediate-release tablet that's taken by mouth twice daily and an extended-release capsule that's taken once daily. The most common side effects are dry mouth and constipation. The brand name Sanctura has been discontinued, but generic trospium is still available.