Key takeaways
Darifenacin ER (formerly branded as Enablex) and trospium (formerly branded as Sanctura adn Sanctura XR) are both medications used to treat overactive bladder (OAB), but they have some differences. Darifenacin, a urinary antispasmodic, is taken once a day and works by blocking certain receptors in your bladder to help relax the muscles. Trospium, an antimuscarinic, is available in both immediate-release tablets taken twice daily and extended-release capsules taken once daily. Trospium works by blocking acetylcholine from attaching to receptors in your bladder, which also helps relax the muscles. While both medications can cause dry mouth and constipation, darifenacin has a higher incidence of these side effects. Additionally, darifenacin can cause drowsiness and dizziness, making it less suitable for those 65 or older. Trospium must be taken on an empty stomach, which can be less convenient. Both medications are available in generic forms, making them more affordable options.
