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Darifenacin ER Coupon - Darifenacin ER 15mg tablet

darifenacin ER

Generic Enablex
Used for Overactive Bladder
Used for Overactive Bladder

Darifenacin hydrobromide is a medication that treats overactive bladder in adults. It belongs to a drug class called anticholinergics. Darifenacin comes as an extended-release tablet that you take by mouth once a day. Common side effects include dry mouth and constipation. The brand name of the medication, Enablex, has been discontinued. So generic darifenacin is the only version available now.

Reviewed by:
reviewer
Robert Chad Hakim, PharmD, BCCCP
reviewer
Cydnee Ng, PharmD
Last reviewed on February 21, 2025
BasicsSide effectsPros & consPharmacist tipsFAQsWarningsDosageInteractionsCostContraindicationsAlternativesLatest newsImagesReferencesPricesMedicare
basics-icon

What is Darifenacin?

What is Darifenacin used for?

How Darifenacin works

Darifenacin is an antimuscarinic medication. But it's more commonly known as an anticholinergic. Antimuscarinics and anticholinergics work in similar ways.

Darifenacin blocks a chemical in the body called acetylcholine from attaching to muscarinic receptors in the bladder. This causes your bladder muscles to relax. The medication helps you go to the bathroom less often and have better control of urination.

Are you looking for information on solifenacin (Vesicare) instead?
When does Darifenacin start working?
Time passed since treatment started:
HOURS
DAYS
WEEKS
MONTHS
Initial effect
Full effect

Drug Facts

Common BrandsEnablex (brand name no longer available)
Drug ClassAnticholinergic
Controlled Substance ClassificationNot a controlled medication
Generic StatusLower-cost generic available
AvailabilityPrescription only
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$290.14(save 90.69%)
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$27.00
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basics-icon

What are the side effects of Darifenacin?

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

Other Side Effects

  • Indigestion
  • Stomach pain
  • Nausea
  • Diarrhea
  • Dizziness
  • Weakness
  • Headache
  • Dry skin
  • Dry eyes
  • Blurry vision
  • Flu-like symptoms
  • Swelling (edema)
  • Weight gain

Serious Side Effects

Contact your healthcare provider immediately if you experience any of the following.
  • Angioedema (severe swelling): swelling of the face, lips, tongue, or throat; trouble breathing
When do Darifenacin possible side effects begin and end?
Time passed since treatment started:
MINUTES
HOURS
DAYS
WEEKS
MONTHS
Dry mouth
Risk of severe swelling of the face, tongue, or throat
Seek immediate medical care if you experience this side effect.
If a line continues to the right, you'll likely keep experiencing this side effect once it starts.

Source: DailyMed

More on Darifenacin side effects

anticholinergics: pills: prescriptions: holding blister pack telehealth 1361867373

8 Anticholinergic Medication Side Effects You Should Know About

Written by Sarah Lobello Pearson, PharmD

The following side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Less common

Bladder pain

bloody or cloudy urine

difficult, burning, or painful urination

frequent urge to urinate

lower back or side pain

Incidence not known

Decrease in the frequency of urination

decrease in the urine volume

difficulty in passing urine

dribbling or painful urination

Get emergency help immediately if any of the following symptoms of overdose occur:

Symptoms of overdose

Changes in vision

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Acid or sour stomach

belching

difficulty having a bowel movement (stool)

dry mouth

heartburn

indigestion

stomach discomfort, upset, or pain

Less common

Diarrhea

dizziness

dry eyes

lack or loss of strength

nausea

Incidence not known

Accidental injury

bloating or swelling of the face, arms, hands, lower legs, or feet

changes in vision

chills

congestion

cough producing mucus

difficulty with breathing

difficulty with moving

dry skin

dryness or soreness of the throat

fever

general feeling of discomfort or illness

headache

hoarseness

itching of the vagina or genital area

itching skin

joint pain

loss of appetite

muscle aches and pains

muscle stiffness

nervousness

pain during sexual intercourse

pain or tenderness around the eyes and cheekbones

pounding in the ears

rash

runny nose

shortness of breath or troubled breathing

slow or fast heartbeat

sneezing

stuffy nose

tender, swollen glands in the neck

thick, white vaginal discharge with no odor or with a mild odor

tightness in the chest

tingling of the hands or feet

trouble with swallowing

unusual weight gain or loss

voice changes

vomiting

wheezing

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

pros-and-cons

Pros and cons of Darifenacin

thumbs-up

Pros

Helps lower the urge to urinate and improves bladder control

Taken by mouth once per day

thumbs-down

Cons

Commonly causes dry mouth, which can be uncomfortable

Not the best choice for people with severe liver problems, certain gut problems, or trouble urinating

pharmacist-tips

Pharmacist tips for Darifenacin

pharmacist

  • You can take darifenacin with or without food. You can try taking it with food to help lessen side effects from the medication like indigestion, nausea, and stomach pain.

    • Swallow the darifenacin tablet whole with water. Don't chew, cut, or crush them. Talk to your prescriber if you're having trouble swallowing the tablets whole.

      • Darifenacin can cause sleepiness, dizziness, and blurry vision, although it isn't common. Don't drive or do things that you need your full attention for until you know how this medication makes you feel.

        • Darifenacin can make you sweat less. This can put you at risk of getting overheated easily, especially when it's hot. To avoid overheating, try not to be outside during the hottest time of the day and avoid dehydrating beverages like alcohol. Drink plenty of water during the day.

          • Tell your healthcare team if you're pregnant or planning to become pregnant. It's not completely known whether darifenacin can harm your unborn baby. Your care team can talk to you about the risks and benefits of taking the medication.

            • It's not clear how safe darifenacin is while breastfeeding because it hasn't been studied in humans. But animal studies show darifenacin can get into breastmilk, which might cause side effects to your baby.

              faqs

              Frequently asked questions about Darifenacin

              Is darifenacin an anticholinergic?
              Yes, darifenacin is an anticholinergic medication. It blocks acetylcholine, a chemical that makes your bladder muscles tighten. This helps lower the urge to urinate and treat overactive bladder.
              How long does it take for darifenacin to work?
              Studies show that darifenacin can start to improve overactive bladder symptoms within 2 weeks. If you don't see any improvement after 2 weeks, let your prescriber know. They might raise your dose. Keep in mind that it can take a few months for you to see the best results from the medication. Talk to your prescriber if you have concerns about how long it's taking for symptoms to improve with treatment.
              What are the most common side effects of darifenacin?
              One of the most common side effects of darifenacin is dry mouth. You can help relieve dry mouth by sucking on ice, chewing gum, or rinsing your mouth with cold water. There are also mouthwashes, sprays, and lozenges that can help. Another common side effect is constipation. To help with this, drink plenty of water during the day and eat more fiber-rich foods. If constipation doesn't go away, ask a healthcare professional if taking a laxative might help. Talk to your prescriber if side effects bother you while you're taking darifenacin.
              Does darifenacin cause weight gain?
              Some people who took darifenacin had weight gain, but it's not common. In studies, up to 2% of people gained weight while taking this medication. To help manage your weight, talk to your healthcare team about a plan that includes a balanced, nutritious diet and regular exercise. Let your prescriber know if you notice unusual weight gain after starting darifenacin.
              Does darifenacin cause dementia?
              Studies suggest that anticholinergic medications like darifenacin might raise the risk of dementia. These studies looked at specific groups of people. This included people taking high doses of anticholinergics, adults over 65, or those who already have memory problems. And in one study, older adults who took darifenacin for 6 to 12 months were more likely to develop dementia than those who took other overactive bladder medications. If you're worried about memory loss from darifenacin, talk to your prescriber.
              What's the difference between darifenacin and oxybutynin?
              Darifenacin and oxybutynin are both anticholinergic medications that treat overactive bladder. Oxybutynin comes in more forms than darifenacin. Oxybutynin comes as a tablet, patch, and gel. But darifenacin is only available as a tablet. Both medications usually need a prescription. But the oxybutynin patch that's specifically for women is available over the counter. Studies show that dry mouth might be less likely with darifenacin than with oxybutynin. Talk to a healthcare professional if you have questions about which medication is right for you.
              What's the difference between darifenacin and solifenacin?
              Darifenacin and solifenacin (Vesicare) are both anticholinergic medications. They're taken once a day for treating overactive bladder in adults. But solifenacin (Vesicare) can also be used to treat people 2 years and older with neurogenic detrusor overactivity (NDO), a bladder problem caused by a nerve condition. What's more, both medications come in tablet form. But solifenacin (Vesicare) is also available as a liquid suspension. This can be easier to take for children and people who have trouble swallowing pills whole. Ask your prescriber if you have questions about how these medications compare.
              Is darifenacin over the counter?
              No. Darifenacin is only available by a prescription from a healthcare professional.
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              warings-icon

              What are the risks and warnings for Darifenacin?

              Darifenacin can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

              risk-warning

              Swelling of the face and possible breathing problems (angioedema)

              Some people who took darifenacin had a rare but serious side effect called angioedema. This causes swelling in different parts of the body, like the face, lips, tongue, or throat. In some cases, this happened after the first dose of darifenacin.

              If the tongue or throat swells, it can be life-threatening because it can make it hard to breathe. Go to the emergency room right away if you suddenly can't breathe or notice swelling around your face or throat.

              risk-warning

              Side effects related to the nervous system

              • Risk factors: Taking other medications that cause nervous system side effects

                Darifenacin can cause sleepiness, dizziness, headaches, and confusion. Some people might also have hallucinations (seeing or hearing things that aren't real). See how you feel when you first start taking darifenacin and when your dose gets raised.

                Tell your care team if you have these side effects. This is especially important if they make it harder for you to go about your daily life. Don't drive or do any activities that you need a lot of focus for until you know how darifenacin affects you.

                Be sure your care team knows about all the medications you take or plan to take. Taking darifenacin with other medications that make you tired can make side effects like sleepiness and dizziness worse. This can raise your risk of falling or having other accidents.

                risk-warning

                Caution in people with blockage in the bladder

                Darifenacin can make it harder to urinate. Let your prescriber know if you already have trouble urinating so they can make sure this medication is safe for you. Some conditions that can block urination include benign prostatic hyperplasia (BPH).

                risk-warning

                Caution in people with digestive problems

                Darifenacin can slow down the gut and make some digestive problems worse. Let your prescriber know if you have a condition that affects how your gut moves. Examples include severe constipation, ulcerative colitis, and myasthenia gravis. They can check whether darifenacin is safe for you to take. People with blockages in their gut can't take this medication at all.

                risk-warning

                Caution in people with glaucoma

                Before you start taking darifenacin, tell your prescriber if you have glaucoma. This medication can make some types of glaucoma worse. So your prescriber should talk to you about the risks and benefits of taking darifenacin.

                Let your ophthalmologist know if you have glaucoma and you're taking darifenacin. They might want to check your eyes more often with regular eye exams.

                dosage

                Darifenacin dosage forms

                The average cost for 30 tablets of 15mg of Darifenacin is $27.85 with a free GoodRx coupon. This is 90.4% off the average retail price of $290.14.
                tablet
                Tablet
                DosageQuantityPrice as low asPrice per unit
                7.5mg30 tablets$27.00$0.90
                15mg30 tablets$27.85$0.93

                Typical dosing for Darifenacin

                The typical starting dose is 7.5 mg by mouth once a day.

                If you have liver problems or take a medication that interacts with darifenacin, your dose will stay at 7.5 mg a day.

                For others, your prescriber might raise your dose of darifenacin to 15 mg once a day after 2 weeks of treatment. This depends on how well the medication is working for you.

                interactions

                Interactions between Darifenacin and other drugs

                Darifenacin may interact with certain medications or supplements. Always let your doctor and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking. The list below does not include all possible drug interactions with Darifenacin. Please note that only the generic name of each medication is listed below.

                Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

                • Potassium

                Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

                Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

                drug-cost

                How much does Darifenacin cost?

                To access savings, use a GoodRx coupon and pay just a fraction of the retail price.
                Darifenacin (generic)
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                contraindications-icon

                Darifenacin contraindications

                Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Darifenacin will not be safe for you to take.
                alternatives

                What are alternatives to Darifenacin?

                There are a number of medications that your doctor can prescribe in place of Darifenacin. Compare a few possible alternatives below.
                Darifenacin
                Used for:
                $27.00 Lowest GoodRx priceView Prices
                Tolterodine (Detrol)
                Used for:

                • Overactive bladder (OAB)

                $24.90 Lowest GoodRx priceView Prices
                Solifenacin (Vesicare)
                Used for:
                $14.75 Lowest GoodRx priceView Prices
                images

                Darifenacin images

                Peach Round 203 - Darifenacin Hydrobromide 15mg Extended-Release Tablet
                This medicine is Peach, Round Tablet Imprinted With "203".Peach Round 203 - Darifenacin Hydrobromide 15mg Extended-Release Tablet
                Peach Round L49 - Darifenacin Hydrobromide 15mg Extended-Release Tablet
                This medicine is Peach, Round Tablet Imprinted With "L49".Peach Round L49 - Darifenacin Hydrobromide 15mg Extended-Release Tablet
                Peach Round L409 - Darifenacin Hydrobromide 15mg Extended-Release Tablet
                This medicine is Peach, Round Tablet Imprinted With "L409".Peach Round L409 - Darifenacin Hydrobromide 15mg Extended-Release Tablet
                Peach Round L409 - Darifenacin Hydrobromide 15mg Extended-Release Tablet
                This medicine is Peach, Round Tablet Imprinted With "L409".Peach Round L409 - Darifenacin Hydrobromide 15mg Extended-Release Tablet
                Peach Round 23 And Z - Darifenacin Hydrobromide 15mg Extended-Release Tablet
                This medicine is Peach, Round Tablet Imprinted With "23" And "Z".Peach Round 23 And Z - Darifenacin Hydrobromide 15mg Extended-Release Tablet
                Peach Round 432 And C - Darifenacin Hydrobromide 15mg Extended-Release Tablet
                This medicine is Peach, Round Tablet Imprinted With "C" And "432".Peach Round 432 And C - Darifenacin Hydrobromide 15mg Extended-Release Tablet

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                References

                Best studies we found

                Aurobindo Pharma Limited. (2021). Darifenacin - darifenacin tablet, film coated, extended release [package insert]. DailyMed.

                Fernandez, J. (2024). Angioedema. Merck Manual Consumer Version.

                Haab, F. (2005). Darifenacin for the treatment of overactive bladder. Women’s Health.

                View All References (6)

                Kroll, P. (2017). Pharmacotherapy for pediatric neurogenic bladder. Paediatric Drugs.

                Matta, R., et al. (2022). Receipt of overactive bladder drugs and incident dementia: A population-based case-control study. European Urology Focus.

                National Association for Continence. (n.d.). The overactive bladder diet.

                National Institute of Diabetes and Digestive and Kidney Diseases. (2019). Definition & facts of urinary retention.

                Sam, C., et al. (2023). Physiology, acetylcholine. StatPearls.

                Torrent Pharmaceuticals Limited. (2024). Darifenacin tablet, extended release [package insert]. DailyMed.

                GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.
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