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Solifenacin Coupon - Solifenacin 10mg tablet

solifenacin

Generic Vesicare
Used for Overactive Bladder
Used for Overactive Bladder

Solifenacin succinate, also known by the brand name Vesicare, is an anticholinergic medication that's used to treating certain bladder problems. The brand-name and generic tablets help treat overactive bladder in adults. A liquid suspension under the brand name Vesicare LS is also available for children with neurogenic detrusor overactivity (NDO) (urinary incontinence due to a neurologic problem). This medication is taken by mouth once per day. The most common side effects are dry mouth and constipation.

Reviewed by:
reviewer
Robert Chad Hakim, PharmD, BCCCP
reviewer
Allison Gourley, PharmD
Last reviewed on October 3, 2024
BasicsSide effectsPros & consPharmacist tipsFAQsWarningsDosageInteractionsCostContraindicationsAlternativesLatest newsImagesReferencesPricesMedicare
basics-icon

What is Solifenacin (Vesicare)?

What is Solifenacin (Vesicare) used for?

How Solifenacin (Vesicare) works

Solifenacin (Vesicare) is an antimuscarinic medication. It's more commonly known as an anticholinergic. This is because antimuscarinics and anticholinergics work very similarly to each other.

Solifenacin (Vesicare) blocks a chemical in the body called acetylcholine from attaching to muscarinic receptors in the bladder. This causes your bladder muscles to relax. The medication helps you to go to the bathroom less often and have better control of urination.

When does Solifenacin (Vesicare) start working?
Time passed since treatment started:
HOURS
DAYS
WEEKS
MONTHS
Initial effect
Full effect

Drug Facts

Common BrandsVesicare, Vesicare LS
Drug ClassAnticholinergic
Controlled Substance ClassificationNot a controlled medication
Generic StatusLower-cost generic available
AvailabilityPrescription only
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Avg retail price
$235.29(save 93.73%)
GoodRx discount
$14.75
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What are the side effects of Solifenacin (Vesicare)?

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Dry mouth (up to 28% in adults, 8% in children)
  • Constipation (up to 13% in adults, 3% in children)

Other Side Effects

Serious Side Effects

Contact your healthcare provider immediately if you experience any of the following.
  • Angioedema (severe swelling): swelling of the face, lips, tongue, or throat; trouble breathing
  • Abnormal heart rhythm: chest pounding, fast heartbeat, irregular heartbeat, chest pain, short of breath, feeling faint or lightheaded
When do Solifenacin (Vesicare) possible side effects begin and end?
Time passed since treatment started:
MINUTES
HOURS
DAYS
WEEKS
MONTHS
Dry mouth
Constipation
Blurry vision
Risk of severe swelling
Risk of abnormal heart rhythm
Seek immediate medical care if you experience this side effect.
If a line continues to the right, you'll likely keep experiencing this side effect once it starts.

Source: DailyMed

The following side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

Constipation

stomach pain

Less common

Bladder pain

bloody or cloudy urine

blurred vision

chills

decrease in the frequency of urination

decrease in urine volume

difficult, burning, or painful urination

dizziness

dry eyes

fever

frequent urge to urinate

headache

lower back or side pain

nervousness

pounding in the ears

slow or fast heartbeat

swelling of the lower legs

unusual tiredness or weakness

Incidence not known

Bloating or swelling of the face, arms, hands, lower legs, or feet

body aches or pain

chest pain or discomfort

confusion

cough

decreased or increased sweating

diarrhea

discouragement

dry skin

fainting

feeling sad or empty

general feeling of discomfort or illness

hives or welts, itching, skin rash

hoarseness

irregular heartbeat recurrent

irritability

joint pain

lack of appetite

large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs

loss of interest or pleasure

muscle aches and pains

redness of the skin

runny or stuffy nose

seeing, hearing, or feeling things that are not there

shivering

sore throat

tender, swollen glands in the neck

tingling of the hands or feet

trouble concentrating

trouble with sleeping

trouble with swallowing

unusual weight gain or loss

voice changes

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Dry mouth

Less common

Acid or sour stomach

belching

heartburn

indigestion

nausea

stomach discomfort or upset

vomiting

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

pros-and-cons

Pros and cons of Solifenacin (Vesicare)

thumbs-up

Pros

Only taken once per day, with or without food

Comes as a tablet and a liquid suspension

Liquid suspension available for children as young as 2 years old

thumbs-down

Cons

Commonly causes dry mouth

Liquid suspension is brand name only

Not a good option for people who have trouble urinating or certain gut problems

pharmacist-tips

Pharmacist tips for Solifenacin (Vesicare)

pharmacist

  • You can take solifenacin (Vesicare) with or without food. Sometimes, the medication can upset your stomach. If this happens, you can try taking it with food to help lessen this side effect.

    • Swallow solifenacin tablets (Vesicare) whole. Don't chew, cut, or crush them. Talk to your prescriber if you're having trouble swallowing the tablets whole.

      • Solifenacin (Vesicare) can cause dizziness, sleepiness, and blurry vision. Don't drive, operate machinery, or do anything that requires concentration until you know how this medication affects you. It's best to avoid drinking alcohol while you're taking solifenacin (Vesicare) because alcohol can worsen sleepiness.

        • Solifenacin (Vesicare) can make you sweat less, which can put you at risk for getting overheated easily, especially when it's hot. To avoid overheating, try not to be outside during the hottest time of the day and avoid dehydrating beverages, like alcohol.

          • Tell your healthcare team if you're pregnant or planning to become pregnant. It's not completely known whether solifenacin (Vesicare) can harm your unborn baby.

            • Let your primary care provider know if you're breastfeeding or planning to nurse. Taking solifenacin (Vesicare) for a long time can lower your milk supply. It's also possible for your baby to have side effects from the medication. Your care team can recommend safe feeding options while you're taking solifenacin (Vesicare).

              More tips for the solifenacin liquid suspension (Vesicare LS):

              • Shake the bottle well to mix the medication before you draw up the dose into an oral syringe.

                • Only use the oral syringes from the pharmacy to measure out the dose. Ask the pharmacy for extras if you need to. Don't use household spoons to measure and take the dose. Household spoons might not be accurate.

                  • Swallow the measured dose of the liquid suspension, then drink water or milk afterwards. It's best not to take the medication at the same time as food or other drinks because it'll cause a bitter taste.

                    • Store the liquid suspension at room temperature and keep it in the original bottle it came in. Throw the bottle away after 28 days of opening it, even if there's still some medication left inside.

                      faqs

                      Frequently asked questions about Solifenacin (Vesicare)

                      How long does solifenacin (Vesicare) take to work?
                      Studies show that solifenacin (Vesicare) can start to lessen symptoms of overactive bladder within a month of treatment. Keep in mind that it can take a few months for you to see the best results from the medication. Speak with your prescriber if you have concerns about how well solifenacin (Vesicare) is working for you and how long it's taking to help with your symptoms.
                      What time of day should I take solifenacin (Vesicare)?
                      The effects of solifenacin (Vesicare) last all day. So you can take the medication at any time of day that's most convenient for you. What's most important is that you're consistent and you take the medication at about the same time every day.
                      Who should not take solifenacin (Vesicare)?
                      Because solifenacin (Vesicare) can cause side effects in many parts of the body, people with certain medical conditions shouldn't use the medication. For example, people with urinary retention, certain stomach problems like gastroparesis (delayed stomach emptying), or eye problems like glaucoma, shouldn't use solifenacin (Vesicare). Also, people who are already taking an anticholinergic medication shouldn't use solifenacin (Vesicare). It's important to tell your care team about all of your medical conditions and medications so they can make sure solifenacin (Vesicare) is a safe choice for you.
                      Can you take tamsulosin (Flomax) and solifenacin (Vesicare) together?
                      Yes, you can take tamsulosin (Flomax) and solifenacin (Vesicare) together if they're both prescribed to you. Studies show that taking these two medications together is safe and works well for people with an enlarged prostate who have symptoms like more frequent urination, more urgent urination, and urinary incontinence (bathroom accidents).
                      How long should you take solifenacin (Vesicare)?
                      There isn't a set amount of time that you'll need to take solifenacin (Vesicare) for. Studies show that taking solifenacin (Vesicare) for up to 1 year worked well and was safe. You'll probably continue to take the medication as long as it's helping your urinary symptoms and you're not having any significant side effects. Talk to your prescriber if you're not sure whether you still need to take solifenacin (Vesicare).
                      Does solifenacin (Vesicare) cause weight gain?
                      No, weight gain isn't a typical side effect of anticholinergic medications like solifenacin (Vesicare). Let your primary care provider know if you notice unusual or unexpected weight gain while you're taking solifenacin (Vesicare). They can try to help you figure out what's causing this weight gain.
                      Does solifenacin (Vesicare) cause constipation?
                      Yes, anticholinergic medications like solifenacin (Vesicare) can cause constipation because they slow down the movement in your gut. In clinical trials, up to 13% of adults who took solifenacin (Vesicare) reported having constipation. You can try to prevent constipation by adding more fiber into your diet and staying hydrated. If you become constipated, there are several over-the-counter medications you can try for relief.
                      Does solifenacin (Vesicare) cause erectile dysfunction?
                      No, solifenacin (Vesicare) doesn't typically cause erectile dysfunction (ED). Let your primary care provider know if you experience ED. They can help identify potential causes and give recommendations for this problem.
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                      What are the risks and warnings for Solifenacin (Vesicare)?

                      Solifenacin (Vesicare) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

                      risk-warning

                      Swelling of the face and possible breathing problems (angioedema)

                      Some people who took solifenacin (Vesicare) have reported experiencing an uncommon, but serious side effect called angioedema. This involves swelling in different parts of the body, including the face, throat, tongue, or around the eyes. Swelling of the tongue or throat area can be life-threatening, since it can make it hard to breathe. Go to the emergency room right away if you suddenly can't breathe or notice swelling around your face or throat.

                      risk-warning

                      Side effects related to the nervous system

                      • Risk factors: Taking other medications that cause nervous system side effects

                        Solifenacin (Vesicare) can cause sleepiness, dizziness, headache, and confusion. It might also cause hallucinations (seeing or hearing things that aren't real). Watch for side effects particularly after you start the medication and after your dose gets raised. Let your care team know if you have any of these side effects, especially if they affect your usual daily activities. Don't drive or do any activities that require a lot of attention until you know how solifenacin (Vesicare) makes you feel.

                        Be sure your care team knows about the other medications you take or plan to take. Taking solifenacin (Vesicare) with other medications that can make you tired can make side effects like sleepiness and dizziness worse. This can raise your risk for falls or other accidents.

                        risk-warning

                        Caution in people with digestive system problems

                        Solifenacin (Vesicare) typically isn't recommended for people with health conditions that cause slowed gut movement. And people with blockages in their gut can't take this medication at all. This is because solifenacin (Vesicare) can slow the gut even more and worsen the digestive condition.

                        Let your primary care provider know if you have any problems with the digestive system, like gastroparesis (delayed stomach emptying). Your care team can check to see whether solifenacin (Vesicare) is safe for you.

                        risk-warning

                        Caution in people with glaucoma

                        Before you start taking solifenacin (Vesicare), let your primary care provider know if you have glaucoma so they can discuss the risks and benefits of this medication. Solifenacin (Vesicare) can worsen a certain type of glaucoma.

                        If you have glaucoma and you do take solifenacin (Vesicare), tell your ophthalmologist that you're taking this medication so they know to follow up with you more closely. You might need to get eye exams done more often to check your eye health.

                        risk-warning

                        QT prolongation (heart rhythm problem)

                        • Risk factors: History of QT prolongation | Taking other medications that cause this same heart rhythm problem | Taking higher-than-recommended doses of solifenacin (Vesicare)

                          Some people who took solifenacin (Vesicare) at higher-than-recommended doses had changes to their heart rhythm called QT prolongation. This happens when it takes longer than usual for your heart to pump and then relax. Call 911 right away if you feel your chest pounding, have chest pain, have shortness of breath, or feel faint or lightheaded while you're taking this medication. These can be signs of irregular heart rhythm.

                          Solifenacin (Vesicare) generally isn't recommended for people who are at risk for QT prolongation, including people who have abnormal electrolyte levels or who take other medications that cause QT prolongation.

                          dosage

                          Solifenacin (Vesicare) dosage forms

                          The average cost for 30 tablets of 10mg of Solifenacin (Vesicare) is $14.75 with a free GoodRx coupon. This is 93.73% off the average retail price of $235.29.
                          tablet
                          Tablet
                          DosageQuantityPrice as low asPrice per unit
                          5mg90 tablets$31.00$0.34
                          10mg30 tablets$14.75$0.49

                          Typical dosing for Solifenacin (Vesicare)

                          • Tablets (adults only): The typical dose is 5 mg to 10 mg by mouth once a day.

                          • Liquid suspension (children age 2 and older): The dose depends on your child's weight. In general, the dose ranges from 2 mL to 10 mL by mouth once a day. Each mL contains 1 mg of medication.

                          interactions

                          Interactions between Solifenacin (Vesicare) and other drugs

                          Solifenacin (Vesicare) may interact with certain medications or supplements. Always let your doctor and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking. The list below does not include all possible drug interactions with Solifenacin (Vesicare). Please note that only the generic name of each medication is listed below.

                          Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

                          Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

                          drug-cost

                          How much does Solifenacin (Vesicare) cost?

                          To access savings, use a GoodRx coupon and pay just a fraction of the retail price.
                          Vesicare (brand)
                          GoodRx lowest price

                          $14.75

                          (save 96.87%)
                          Solifenacin (Vesicare) (generic)
                          GoodRx lowest price

                          $14.75

                          (save 93.73%)
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                          contraindications-icon

                          Solifenacin (Vesicare) contraindications

                          Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Solifenacin (Vesicare) will not be safe for you to take.
                          alternatives

                          What are alternatives to Solifenacin (Vesicare)?

                          There are a number of medications that your doctor can prescribe in place of Solifenacin (Vesicare). Compare a few possible alternatives below.
                          Solifenacin (Vesicare)
                          Used for:
                          $14.75 Lowest GoodRx priceView Prices
                          Oxybutynin
                          Used for:

                          • Overactive bladder

                          • Incontinence in children due to a neurologic (brain) condition, such as spina bifida

                          $8.50 Lowest GoodRx priceView Prices
                          Tolterodine (Detrol)
                          Used for:

                          • Overactive bladder (OAB)

                          $29.19 Lowest GoodRx priceView Prices
                          images

                          Solifenacin (Vesicare) images

                          Pink Round 329 And U - Solifenacin Succinate 10mg Tablet
                          This medicine is Pink, Round Tablet Imprinted With "329" And "U".Pink Round 329 And U - Solifenacin Succinate 10mg Tablet
                          White Round 19 And V - Solifenacin Succinate 10mg Tablet
                          This medicine is White, Round Tablet Imprinted With "V" And "19".White Round 19 And V - Solifenacin Succinate 10mg Tablet
                          White Round 19 And V - Solifenacin Succinate 10mg Tablet
                          This medicine is White, Round Tablet Imprinted With "V" And "19".White Round 19 And V - Solifenacin Succinate 10mg Tablet
                          Yellow Round Ap 29 - Solifenacin Succinate 10mg Tablet
                          This medicine is Yellow, Round Tablet Imprinted With "Ap 29".Yellow Round Ap 29 - Solifenacin Succinate 10mg Tablet
                          Pink Round 428 And Sg - Solifenacin Succinate 10mg Tablet
                          This medicine is Pink, Round Tablet Imprinted With "428" And "Sg".Pink Round 428 And Sg - Solifenacin Succinate 10mg Tablet
                          Pink Round 428 And Sg - Solifenacin Succinate 10mg Tablet
                          This medicine is Pink, Round Tablet Imprinted With "428" And "Sg".Pink Round 428 And Sg - Solifenacin Succinate 10mg Tablet
                          Pink Round 428 And Sg - Solifenacin Succinate 10mg Tablet
                          This medicine is Pink, Round Tablet Imprinted With "428" And "Sg".Pink Round 428 And Sg - Solifenacin Succinate 10mg Tablet
                          Pink Round 24 - Solifenacin Succinate 10mg Tablet
                          This medicine is Pink, Round Tablet Imprinted With "24".Pink Round 24 - Solifenacin Succinate 10mg Tablet
                          Pink Round 432 And L - Solifenacin Succinate 10mg Tablet
                          This medicine is Pink, Round Tablet Imprinted With "L" And "432".Pink Round 432 And L - Solifenacin Succinate 10mg Tablet
                          Pink Round S 10 - Solifenacin Succinate 10mg Tablet
                          This medicine is Pink, Round Tablet Imprinted With "S 10".Pink Round S 10 - Solifenacin Succinate 10mg Tablet
                          Pink Round 52 And G - Solifenacin Succinate 10mg Tablet
                          This medicine is Pink, Round Tablet Imprinted With "G" And "52".Pink Round 52 And G - Solifenacin Succinate 10mg Tablet
                          Pink Round 09 - Solifenacin Succinate 10mg Tablet
                          This medicine is Pink, Round Tablet Imprinted With "09".Pink Round 09 - Solifenacin Succinate 10mg Tablet

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                          References

                          Best studies we found

                          Astellas Pharma US, Inc. (2022). Vesicare LS- solifenacin succinate suspension [package insert]. DailyMed.

                          Drugs and Lactation Database (LactMed®). (2021). Solifenacin. National Institute of Child Health and Human Development.

                          Fernandez, J. (2024). Angioedema. Merck Manual Consumer Version.

                          View All References (12)

                          Govier, F. E., et al. (2010). Efficacy and safety of 10 mg solifenacin succinate in patients with overactive bladder syndrome: Results from a randomized, double-blind, placebo-controlled phase III pivotal trial. Clinical Medicine Insights: Urology.

                          Gratzke, C., et al. (2018). Long-term safety and efficacy of mirabegron and solifenacin in combination compared with monotherapy in patients with overactive bladder: A randomised, multicentre phase 3 Study (SYNERGY II). European Urology.

                          Haab, F., et al. (2005). Long-term open-label solifenacin treatment associated with persistence with therapy in patients with overactive bladder syndrome. European Urology.

                          Kroll, P. (2017). Pharmacotherapy for pediatric neurogenic bladder. Paediatric Drugs.

                          Macleods Pharmaceuticals Limited. (2024). Solifenacin succinate tablet, coated [package insert]. DailyMed.

                          National Institute of Diabetes and Digestive and Kidney Diseases. (2018). Gastroparesis.

                          National Institute of Diabetes and Digestive and Kidney Diseases. (2019). Definition and facts of urinary retention.

                          National Institute of Diabetes and Digestive and Kidney Diseases. (2019). Urinary retention.

                          Sam, C., et al. (2023). Physiology, acetylcholine. StatPearls.

                          Shim, J. H., et al. (2021). Efficacy and tolerability of solifenacin fumarate with overactive bladder patients: A multicenter observational study. Urogenital Tract Infection.

                          Song, Y., et al. (2020). Effects of tamsulosin combined with solifenacin on lower urinary tract symptoms: Evidence from a systematic review, meta-analysis, and trial sequential analysis of randomized controlled trials. Frontiers in Pharmacology.

                          Zaitsu, M., et al. (2011). Comparative evaluation of the safety and efficacy of long-term use of imidafenacin and solifenacin in patients with overactive bladder: A prospective, open, randomized, parallel-group trial (the LIST Study). Advances in Urology.

                          GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.
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