Compare Gemtesa vs. Trospium

Vibegron (Gemtesa) and trospium are both medications used to treat overactive bladder (OAB) in adults. However, they belong to different medication classes. Vibegron is a beta-3 adrenergic agonist, which works by relaxing bladder muscles to help it hold more urine. Trospium, on the other hand, is an antimuscarinic (or anticholinergic) that blocks acetylcholine to relax bladder muscles. Vibegron is taken as a 75 mg tablet once daily, while trospium is available in two forms: an immediate-release tablet taken twice daily and an extended-release capsule taken once daily. Vibegron is only available as a brand-name medication, whereas trospium is available as a generic. Common side effects of vibegron include headache and cold symptoms, while trospium often causes dry mouth and constipation. Additionally, trospium can cause nervous system side effects like sleepiness and dizziness, which are not typical with vibegron. Both medications can cause angioedema, a serious swelling reaction that can affect breathing. Trospium should be taken on an empty stomach, and you should avoid alcohol while taking it, as it can worsen side effects.