Myrbetriq
Myrbetriq (mirabegron) is used to treat overactive bladder (OAB) symptoms in adults. It can also be taken by children ages 3 years and older to treat neurogenic detrusor overactivity (NDO). This medication is taken by mouth, typically once daily. It's available as tablets and granules for suspension. Some of the more common side effects of Myrbetriq (mirabegron) include high blood pressure, the common cold, and urinary tract infection. Currently, there's no generic version of Myrbetriq (mirabegron) available.
What is Myrbetriq (mirabegron)?
What is Myrbetriq (mirabegron) used for?
Overactive bladder in adults
Neurogenic detrusor overactivity (NDO) in children ages 3 years and older
How Myrbetriq (mirabegron) works
Myrbetriq (mirabegron) is a beta agonist that activates (wakes up) certain proteins in your bladder that cause your bladder muscles to relax. This makes the bladder to hold on to more urine, allowing you to go to the bathroom less often.
Drug Facts
More on Myrbetriq (mirabegron) essentials
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What are the side effects of Myrbetriq (mirabegron)?
Common Side Effects
- High blood pressure (8-11%)
- Common cold symptoms (4%)
- Urinary tract infection (3-4%)
- Headache (2-3%)
- Constipation (2%)
- Upper respiratory tract infection (2%)
- Urinary tract infection (24%)
- Common cold symptoms (6%)
- Constipation (5%)
- Headache (4%)
- Nausea (2%)
Other Side Effects
- Joint pain
- Diarrhea
- Fast heart rate
- Stomach pain
- Fatigue
Serious Side Effects
- Angioedema: swelling of your face, lips, tongue and/or throat
- High blood pressure: headache, vision changes, dizziness
Source: DailyMed
More on Myrbetriq (mirabegron) side effects
The following side effects have also been reported
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur:
More common
Bladder pain
bloody or cloudy urine
blurred vision
difficult, burning, or painful urination
dizziness
frequent urge to urinate
headache
lower back or side pain
nervousness
pounding in the ears
slow, fast, or irregular heartbeat
Rare
Blindness
decrease in vision
lower abdominal or stomach pain
pain in the groin or genitals
tearing or eyes
vomiting
Incidence not known
Blistering, peeling, or loosening of the skin
chills
confusion
decrease in the frequency of urination
decrease in urine volume
difficulty in passing urine (dribbling)
joint or muscle pain
large, hive-like swelling on face, eyelids, lips, tongue, throat, hands, legs, feet, or genitals
red skin lesions, often with a purple center
red, irritated eyes
seeing, hearing, or feeling things that are not there
sores, ulcers, or white spots in the mouth or on the lips
trouble sleeping
unusual tiredness or weakness
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Less common
Back pain
body aches or pain
difficulty having a bowel movement
difficulty with breathing
difficulty with moving
ear congestion
general feeling of discomfort or illness
loss of voice
muscle ache or stiffness
shivering
stomach pain
stuffy or runny nose
sweating
Rare
Belching
burning feeling in the chest or stomach
full or bloated feeling
hives or welts, skin rash
indigestion
itching or pain of the vagina or genital area
pain or tenderness around the eyes and cheekbones
pressure in the stomach
redness of the skin
stomach discomfort, upset, or tenderness
swelling of the lips
thick, white vaginal discharge with mild or no odor
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
Pros and cons of Myrbetriq (mirabegron)
Pros
Helps you to have better control over OAB symptoms such as urgency, frequency, and leakage
Only taken once a day
Causes less drowsiness and constipation than other medications for overactive bladder
Might be safer to use compared to other medications for overactive bladder if you're over 65 years old
Cons
Might raise your blood pressure
You can have difficulty emptying your bladder completely if you have a blockage in your bladder or if you're taking certain OAB medications together with Myrbetriq (mirabegron).
No generic available
Not recommended if you have severe kidney or liver problems
Pharmacist tips for Myrbetriq (mirabegron)
Myrbetriq (mirabegron) is a medication that's released slowly in your body over time so the tablet shouldn't be broken. Swallow it whole. Don't crush, break, or chew it.
Adults can take Myrbetriq (mirabegron) with or without food. Children should take it with food to lessen the potential for side effects like a fast heartbeat.
If you miss a Myrbetriq (mirabegron) dose, take the dose as soon as you remember, unless more than 12 hours have gone by since you missed your dose. If more than 12 hours have gone by, skip the dose and take your next dose at the regular time. Don't double up on doses because that can raise your risk of experiencing side effects.
Myrbetriq (mirabegron) can raise your blood pressure. Make sure to tell your provider if you have a history of high blood pressure. They might recommend checking your blood pressure regularly while taking the medication.
Additional tips for Myrbetriq Granules:
You should take Myrbetriq granules with food.
Before measuring out the dose of Myrbetriq granules, shake the bottle for 1 minute and then set it down. Wait until the foam on the top is gone (1 to 2 minutes). If the granules aren't mixed into the solution well, shake the medication again strongly for 1 minute and set it down until the foam is gone.
Use the dosing device the pharmacist provides and take the dose within 1 hour with food.
If you aren't going to use the medication for 2 or more days, shake the bottle for 1 minute every day to make sure the granules are mixed into the liquid well.
Store Myrbetriq Granules at room temperature. It expires after 28 days. Any remaining medication after 28 days should be thrown away.
Frequently asked questions about Myrbetriq (mirabegron)
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What are the risks and warnings for Myrbetriq (mirabegron)?
Myrbetriq (mirabegron) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.
High blood pressure
Risk factors: Uncontrolled high blood pressure
Taking Myrbetriq (mirabegron) can raise your blood pressure. It isn't recommended for people with severe, uncontrolled high blood pressure. Ask your provider how often you should check your blood pressure while taking Myrbetriq (mirabegron) to make sure it's in a healthy range. Most of the time, you won't feel any symptoms if your blood pressure is high. But in cases when your blood pressure is extremely high, you might experience symptoms such as headaches, chest pain, and changes in vision; get medical attention right away if this happens.
Risk of difficulty emptying the bladder completely
Risk factors: Blockage in the bladder | Use of certain overactive bladder medications
If you have a blockage in your bladder or use other medications for overactive bladder, talk to your provider before taking Myrbetriq (mirabegron). There's a risk that taking Myrbetriq (mirabegron) under these circumstances might make it difficult for you to empty your bladder fully, though no cases have been reported yet. Keeping urine in your bladder for long periods of time can lead to complications, such as bladder damage and infections. Let your provider know if you notice that you can't empty your bladder, even though it feels full.
Unusual swelling of the face, lips, or throat (angioedema)
Myrbetriq (mirabegron) can rarely cause unusual swelling likely due to an allergic reaction (angioedema), which can make it hard to breathe. This can happen right after taking the first dose, or after taking multiple doses. Get medical help right away if your throat swells or if you have a hard time breathing.
Risk of medication interactions
Myrbetriq (mirabegron) can affect how other medications work. For examples, taking it with medications such as digoxin (Lanoxin) and warfarin (Coumadin) can raise the levels of those medications in your body and raise your risk for side effects. Your doctor might closely monitor and adjust your dose if you take Myrbetriq (mirabegron) at the same time as these other medications. Tell your healthcare provider about all of the medications (prescription and over-the-counter), vitamins, and supplements you take before starting Myrbetriq (mirabegron).
Myrbetriq (mirabegron) dosage forms
Typical dosing for Myrbetriq (mirabegron)
Myrbetriq (mirabegron) is available as Myrbetriq tablets or Myrbetriq granules for suspension. Each mL of Myrbetriq granules for suspension contains 8 mg of mirabegron. These medications can't be used in place of each other.
Overactive bladder (OAB)
Adults (Myrbetriq tablets): The typical starting dose is 25 mg by mouth once a day. It can be taken alone or together with 5 mg of solifenacin (Vesicare). If needed, your healthcare provider might raise your dose to 50 mg once a day after 1 to 2 months.
Neurogenic detrusor overactivity (NDO)
Children 77 pounds (35 kg) or less
Myrbetriq granules: Your child's provider will determine the dose based on your child's body weight. The dose typically ranges from 24 mg to 64 mg by mouth once daily.
Children 77 pounds (35 kg) or more
Myrbetriq tablets: The typical starting dose is 25 mg by mouth once a day. If needed, your healthcare provider might raise your dose to 50 mg once a day after 1 to 2 months.
Myrbetriq granules: The typical starting dose is 48 mg by mouth once a day. If needed, your child's provider might raise the dose to 80 mg once a day after 1 to 2 months.
Your dose might differ if you have kidney or liver problems.
Interactions between Myrbetriq (mirabegron) and other drugs
Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.
- Eliglustat
- Thioridazine
Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
- Clozapine
- Codeine
- Dihydrocodeine
- Propafenone
- Sirolimus
- Tramadol
Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
How much does Myrbetriq (mirabegron) cost?
What are alternatives to Myrbetriq (mirabegron)?
Overactive bladder in adults
Neurogenic detrusor overactivity (NDO) in children ages 3 years and older
Overactive bladder
Incontinence in children due to a neurologic (brain) condition, such as spina bifida
What is the latest news about Myrbetriq (mirabegron)?
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References
Best studies we foundAl-Shaiji, T. F., et al. (2012). Relationship between body mass index and overactive bladder in women and correlations with urodynamic evaluation. International Neurourology Journal.
Astellas Pharma US, Inc. (n.d.). Why Myrbetriq?
Astellas Pharma US, Inc. (2022). Myrbetriq- mirabegron tablet, film coated, extended release [package insert]. DailyMed.
Centers for Disease Control and Prevention. (2020). Spoons are for soup, milliliters are for medicine.
Memon, R. J., et al. (2023). Angioedema. StatPearls.
National Institute of Diabetes and Digestive and Kidney Diseases. (2019). Definition and facts of urinary retention.
Selius, B. A., et al. (2008). Urinary retention in adults: Diagnosis and initial management. American Family Physician.
U.S. Food and Drug Administration. (2021). FDA approves new indication for drug to treat neurogenic detrusor overactivity in pediatric patients.
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