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Dupixent vs. Xolair

Dupixent (dupilumab) is an injection that helps treat certain inflammatory conditions. This includes eczema, asthma, and chronic obstructive pulmonary disease (COPD), among others. It's a biologic medication known as an interleukin antagonist that lowers inflammation. Dupixent (dupilumab) comes as prefilled pens and prefilled syringes. It's injected under the skin of the belly or thighs (or in the back of the upper arm with someone's help). The dosing schedule depends on the condition you have, your age, and your weight. It's injected either every week, every 2 weeks, or every 4 weeks. Side effects include injection site reactions and eye problems.

• Moderate-to-severe eczema - for people 6 months and older
• Moderate-to-severe asthma - add-on maintenance for people 6 years and older
• Long-term sinus congestion with nasal polyps - add-on maintenance for people 12 years and older
• Eosinophilic esophagitis - for people 1 year and older
• Prurigo nodularis (long-term itchy skin bumps) - for adults
• Chronic obstructive pulmonary disease (COPD) - add-on maintenance for adults
• Long-term hives - for people 2 years and older
• Bullous pemphigoid (blisters on the skin) - for adults
• Allergic fungal rhinosinusitis (sinus swelling due to fungi) - for people 6 years and older

• Injection site reaction (e.g., pain, swelling, bruising; 10%)
• Eye redness or eye inflammation (10%)
• Cold sores (4%)

• Allergic reactions
• Eye inflammation
• Other inflammation in the body
• Risk of worsening of breathing problems in people with asthma or COPD
• Risk of psoriasis
• Joint pain and psoriatic arthritis
• Unknown effect in people with parasitic worm infections
• Interaction with vaccines

Xolair (omalizumab) is a prescription injection used to treat allergic asthma, chronic hives, and nasal polyps. It's also approved to help lower the risk of food allergy reactions if you or your child are accidentally exposed to a trigger. Xolair (omalizumab) is a monoclonal antibody that works by calming your immune system to reduce inflammation and allergy symptoms. You'll get it as a shot under the skin the every 2 or 4 weeks. Common side effects include headache, stomach pain, and dizziness.

• Moderate-to-severe allergic asthma - people 6 years and older
• Chronic rhinosinusitis (sinus inflammation) with nasal polyps - adults only
• To prevent food allergy reactions after accidental exposure - people 1 year and older
• Chronic hives - people 12 years and older

Allergic asthma:

• Joint pain (8%)
• Body pain (7%)
• Leg pain (4%)
• Dizziness (3%)
• Tiredness (3%)

Chronic rhinosinusitis with nasal polyps:

• Headache (8%)
• Injection site reactions (5%)

Chronic hives:

• Headache (up to 12%)
• Common cold symptoms (up to 9%)
• Sinus inflammation (up to 5%)

Prevention of food allergy reactions:

• Injection-site reactions (16%)
• Fever (6%)

• Severe allergic reaction
• Cancer risk
• Not for an asthma attack
• Don't stop corticosteroids suddenly
• Inflammation of blood vessels
• Fever, muscle pain, and rash
• Parasitic infections
• Not for emergency treatment