Skip to main content
HomeDrug Comparisons
Drug bottle and Pill

Compare Eucrisa vs. Opzelura

Head-to-head comparisons of medication uses, side effects, warnings, and more.

  • Eucrisa (crisaborole)
    Opzelura (ruxolitinib)
  • Eucrisa (crisaborole)
    Opzelura (ruxolitinib)

  • Summary of Eucrisa vs. Opzelura

    Summary for PDE4 inhibitor
    Prescription only

    Eucrisa (crisaborole) is an ointment that's used to treat eczema for people 3 months and older. The medication is a phosphodiesterase 4 (PDE4) inhibitor that works to help reduce skin inflammation and itching from eczema. The ointment is usually applied to the affected area(s) of skin twice a day. The most common side effect is burning or stinging on the skin where you apply the medication.

    Summary for JAK inhibitor
    Prescription only

    Opzelura (ruxolitinib) is a topical Janus kinase (JAK) inhibitor. It's a non-steroid cream used to treat atopic dermatitis (eczema) and nonsegmental vitiligo (a condition where skin loses its color) in adults and children ages 12 years and older. Opzelura (ruxolitinib) is applied directly on the skin twice daily. Even though Opzelura (ruxolitinib) has the same black box warnings as oral JAK inhibitors, it's less likely to cause serious side effects compared to oral medications. Some of the more commonly reported side effects of Opzelura (ruxolitinib) include acne, itching or redness, and symptoms of the common cold.

  • Indications of Eucrisa vs. Opzelura

    Indications for
    •Mild-to-moderate eczema
    Indications for
    •Mild-to-moderate eczema that didn't respond well to or can't be treated by other medications
    •Vitiligo that appears on both sides of the body (nonsegmental)

  • Pros and Cons of Eucrisa vs. Opzelura

    Pros and Const for PDE4 inhibitor
    Pros
    •Easy-to-apply ointment
    •Safe to use on children as young as 3 months old
    •Can start to see improvement in your skin in about 1 week
    •An alternative to topical steroids to treat eczema
    Cons
    •Must use twice daily
    •Can cause pain, burning, or stinging on the skin
    •Not approved for severe eczema
    •No lower-cost generic available
    Pros and Const for JAK inhibitor
    Pros
    •Applied directly onto the skin
    •Approved for children ages 12 years and older
    •Possible option for people who haven't had success with other treatments for eczema and vitiligo
    Cons
    •Applied twice daily
    •Brand name only; no generic available
    •Not recommended during breastfeeding

  • Common Side Effects of Eucrisa vs. Opzelura

    Common Side Effects for
    •Pain, burning, or stinging where the medication is applied (4%)
    Common Side Effects for

    Atopic dermatitis:

    •Runny nose, sore throat (3%)
    •Bronchitis (1%)
    •Ear infection (1%)
    •Hives (1%)
    •Diarrhea (1%)
    •Redness and swelling around hair pores (1%)
    •Swelling of the tonsils (1%)

    Nonsegmental vitiligo:

    •Acne on application site (6%)
    •Itching on application site (5%)
    •Runny nose, sore throat (4%)
    •Headache (4%)
    •Urinary tract infection (2%)
    •Redness on application site (2%)

  • Warnings of Eucrisa vs. Opzelura

    Common Side Effects for
    •Allergic reactions
    Common Side Effects for
    •Serious infections
    •Possible higher risk of death
    •Possible risk of cancer
    •Possible risk of heart attack, stroke, and other blood clots
    •Low blood cell counts
    •High cholesterol

  • Prices with our coupons for Eucrisa vs. Opzelura

    Learn more about Eucrisa
    Learn more about Opzelura

Compare other Eczema drugs

Eucrisa vs DupixentEucrisa vs ElidelEucrisa vs TemovateDuobrii vs SkyriziDupixent vs AdbryDupixent vs FasenraDupixent vs SymbicortDupixent vs XolairEbglyss vs DupixentEntyvio vs SkyriziEohilia vs DupixentNucala vs DupixentOhtuvayre vs DupixentOmvoh vs SkyriziRinvoq vs DupixentRinvoq vs SkyriziSkyrizi vs BimzelxSkyrizi vs CosentyxSkyrizi vs DupixentSkyrizi vs EnbrelSkyrizi vs HumiraSkyrizi vs IlumyaSkyrizi vs OtezlaSkyrizi vs RemicadeSkyrizi vs SimponiSkyrizi vs TaltzSotyktu vs SkyriziStelara vs SkyriziTezspire vs DupixentTremfya vs Dupixent
View More

Browse medications

View All

Research prescriptions and over-the-counter medications from A to Z, compare drug prices, and start saving.