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Hyoscyamine Coupon - Hyoscyamine 0.125mg sublingual tablet

hyoscyamine

Generic Levsin
Used for Cold Symptoms, Cystitis, Irritable Bowel Syndrome, Overactive Bladder, Parkinson's Disease, Peptic Ulcer

Hyoscyamine sulfate is an anticholinergic medication used to treat conditions that involve muscle spasms in different parts of the body, including irritable bowel syndrome (IBS), stomach ulcers, and overactive bladder. It comes in several oral forms including immediate-release tablets, extended-release tablets, sublingual tablets, and liquid solutions. You typically take it by mouth 3 to 4 times a day. Some side effects include dry mouth, sleepiness, and dizziness.

Reviewed by:
reviewerRobert Chad Hakim, PharmD, BCCCP
reviewerDaisy Chau, PharmD
Last reviewed on April 20, 2026
basics-icon

What is Hyoscyamine?

What is Hyoscyamine used for?

How Hyoscyamine works

Hyoscyamine is an anticholinergic. It works by blocking a chemical in your body called acetylcholine, which controls muscle movement and secretions.

By blocking acetylcholine, hyoscyamine helps relax muscles in your stomach, intestines, and bladder. This can reduce cramping, spasms, and extra secretions.

When does Hyoscyamine start working?Time passed since treatment started:
MINUTES
Initial effect
HOURS
Full effect
DAYS
WEEKS
MONTHS

Drug facts

Common BrandsLevsin, Levbid, Hyosyne, Oscimin
Drug ClassAnticholinergic
Controlled Substance ClassificationNot a controlled medication
Generic StatusLower-cost generic available
AvailabilityPrescription only
side-effects-icon

Side effects of Hyoscyamine

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Dry mouth
  • Trouble urinating
  • Constipation
  • Blurry vision
  • Dry eyes
  • Sleepiness
  • Dizziness
  • Headache
  • Flushing
  • Heat intolerance

Less Common Side Effects

  • Fast heart rate
  • Diarrhea
  • Confusion
  • Short-term memory loss

Hyoscyamine serious side effects

Contact your healthcare provider immediately if you experience any of the following.

  • Changes in mood or behavior: psychosis, agitation, hallucinations, confusion, euphoria
  • Irregular heartbeat: pounding heartbeat, fainting, dizziness or lightheadedness, chest discomfort, shortness of breath, tiredness
  • Overheating: not sweating, fever, hot/dry skin, headache
  • Urination problems: trouble urinating, painful urination, urinating less
  • Bowel blockage: severe constipation, stomach pain, vomiting, bloating

Source: DailyMed

The following Hyoscyamine side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Rare

Confusion (especially in the elderly)

dizziness, lightheadedness that continues, or fainting

eye pain

skin rash or hives

Incidence not known

Cough

difficulty with swallowing

fast irregular, pounding, or racing heartbeat or pulse

fever

hives or welts

hoarseness

irritation

itching skin

joint pain, stiffness, or swelling

puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue

redness of the skin

shortness of breath

skin rash

tightness in the chest

trouble with breathing

wheezing

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Constipation

decreased sweating

dryness of the mouth, nose, throat, or skin

Less common or rare

Bloated feeling

blurred vision

difficult urination

difficulty with swallowing

drowsiness

false sense of well-being

headache

increased sensitivity of eyes to light

loss of memory

nausea or vomiting

redness or other signs of irritation at the place of injection

trouble with sleeping

unusual tiredness or weakness

Incidence not known

Decreased interest in sexual intercourse

inability to have or keep an erection

loss in sexual ability, desire, drive, or performance

loss of taste

For patients using scopolamine:

After you stop using scopolamine, your body may need time to adjust. The length of time this takes depends on the amount of scopolamine you were using and how long you used it. During this period of time check with your doctor if you notice any of the following side effects:

Anxiety

irritability

nightmares

pupil of one eye is larger (patch only)

sensitivity of eyes to light (patch only)

trouble in sleeping

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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Avg retail price
$27.42(Save 55.43%)
GoodRx discount
$12.22
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Pros and cons of Hyoscyamine

Pros

  • Works quickly to relieve symptoms
  • Comes in several different forms
  • Safe for both children and adults

Cons

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Pharmacist tips for Hyoscyamine

pharmacist
  • Take hyoscyamine exactly as prescribed. You’ll usually take it 30 minutes to 1 hour before meals.
  • Hyoscyamine can cause dizziness and raise your risk of falling. Let your prescriber know if you're taking benzodiazepines, anxiety medications, or muscle relaxants. These can make side effects like sleepiness and confusion worse.
  • If you take antacids, take hyoscyamine before meals and your antacid after meals. This helps both medications work properly.
  • Hyoscyamine can cause dry mouth because it lowers saliva. Drink enough water to stay comfortable.
  • Hyoscyamine can affect your thinking and reaction time. Don’t drive or do tasks that need focus until you know how it affects you.
  • Hyoscyamine can make you sweat less, which can raise your risk of overheating. Drink plenty of water and be careful in hot weather.
  • Hyoscyamine can make it harder to urinate. Contact your prescriber if you have difficulty urinating or pain.

How to take hyoscyamine:

  • Immediate-release and extended-release tablets: Swallow the tablets whole. Don’t crush, chew, or split them. Talk to your prescriber if you have trouble swallowing.
  • Sublingual tablet: Place the tablet under your tongue to dissolve. Don’t eat, drink, or smoke while it’s dissolving. You can swallow your saliva, but don’t swallow the tablet.
  • Dissolvable tablet (ODT): Make sure your hands are dry before handling the medication. Place the tablet on your tongue and let it dissolve.

Hyoscyamine liquid:

  • The oral drops contain 0.125 mg/mL and the elixir contains 0.125 mg/5 mL. Double check your bottle and the prescribed dose to avoid accidentally taking the wrong amount.
  • Store the medication bottle at room temperature and keep it in the original bottle to protect from light.
  • Use a proper measuring device to take the liquid. Don’t use household spoons because they aren’t accurate.
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Risks and warnings for Hyoscyamine

Hyoscyamine can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

Dizziness

Hyoscyamine can make you feel sleepy, dizzy, or have blurry vision. Don’t drive or do activities that need focus until you know how this medication affects you.

Heat intolerance

  • Risk factors: Hot environments

Hyoscyamine reduces sweating, which raises your risk of overheating or heat stroke. Symptoms include high body temperature, dry skin, and confusion. Stay hydrated and avoid excessive heat.

Intestinal blockage

  • Risk factors: Colostomy or ileostomy

Hyoscyamine can slow your gut too much, which can lead to serious problems like swelling or inflammation of your colon. Your risk is higher if you’ve had certain gut surgeries.

Tell your prescriber before taking hyoscyamine if you’ve ever had a colostomy or ileostomy. Sometimes diarrhea can be a sign of a blockage, and taking this medication in that case can be harmful.

Faster heart rate

  • Risk factors: Heart problems | Overactive thyroid

If you have heart problems, such as heart failure or abnormal heart rhythms, let your prescriber know. Hyoscyamine can cause your heart rate to go up, which can worsen certain heart conditions. Let your prescriber know if you notice a change with your heart rate or feel symptoms such as a pounding or racing heart.

Reduced saliva

  • Risk factors: Taking hyoscyamine for a long time

Taking anticholinergics, like hyoscyamine, for a long time can reduce how much saliva your mouth makes. This can raise your risk of cavities, gum problems, and mouth infections. It can also make your mouth feel dry and uncomfortable. Let your prescriber know if this becomes bothersome.

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Hyoscyamine dosage

The average cost for 30 sublingual tablets of 0.125mg of Hyoscyamine is $12.83 with a free GoodRx coupon. This is 59.32% off the average retail price of $31.54.
dropperDropper
DosageQuantityPrice as low asPrice per unit
15ml of 0.125mg/ml1 dropper$16.20$16.20
20ml of 0.125mg/ml1 dropper$19.61$19.61
ml of elixirMl of elixir
DosageQuantityPrice as low asPrice per unit
0.125mg/5ml473 ml$48.95$0.10
orally disintegrating tabOrally disintegrating tab
DosageQuantityPrice as low asPrice per unit
0.125mg30 orally disintegrating tabs$12.22$0.41
sublingual tabletSublingual tablet
DosageQuantityPrice as low asPrice per unit
0.125mg30 sublingual tablets$12.83$0.43
tabletTablet
DosageQuantityPrice as low asPrice per unit
0.125mg30 tablets$12.76$0.43

Typical dosage for Hyoscyamine

Hyoscyamine comes in many different forms, including immediate-release (IR) tablets, extended-release (ER) tablets, orally disintegrating tablets, and liquid solutions. Follow your prescriber’s instructions for your specific product.

Some examples include:

  • Hyoscyamine 0.125 mg immediate-release (IR) tablet:

    • Age 12 years or older: The typical dose is 1 to 2 tablets every 4 hours or as needed. The maximum dose is 12 tablets within 24 hours.
    • Age 2 to under 12 years (IR tablet only): The typical dose is half a tablet to 1 tablet every 4 hours or as needed. The maximum dose is 6 tablets within 24 hours.

  • Hyoscyamine 0.375 mg extended-release (ER) tablets:

    • Age 12 years or older: The typical dose is 1 to 2 tablets by mouth every 12 hours. The maximum dose is 4 tablets within 24 hours.

  • Hyoscyamine 0.125 mg/1 mL liquid solution:

    • Age 12 years or older: The typical dose is 1 to 2 mL by mouth every 4 hours or as needed. The maximum dose is 12 mL within 24 hours.
    • Age 2 to under 12 years: The typical dose is ¼ to 1 mL by mouth every 4 hours or as needed. Do not take more than 6 mL within 24 hours.
    • Age under 2 years: The dose depends on your child's weight. In general, the typical dose ranges from 4 drops to 8 drops by mouth every 4 hours or as needed.

There's also an injectable form that's used for people in the hospital who can't take the medication by mouth.

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Interactions between Hyoscyamine and other drugs

Hyoscyamine may interact with certain medications or supplements. Always let your doctor and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking. The list below does not include all possible drug interactions with Hyoscyamine. Please note that only the generic name of each medication is listed below.

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking any of these medicines, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using medicines in this class with any of the following medicines is not recommended. Your doctor may decide not to treat you with a medication in this class or change some of the other medicines you take.

Using medicines in this class with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

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How much does Hyoscyamine cost?

To access savings, use a GoodRx coupon and pay just a fraction of the retail price.
Levsin (brand)
GoodRx lowest price

$12.22

(save 89.20%)
Hyoscyamine (generic)
GoodRx lowest price

$12.22

(save 90.18%)
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Hyoscyamine contraindications

Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Hyoscyamine will not be safe for you to take.

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What are alternatives to Hyoscyamine?

There are a number of medications that your doctor can prescribe in place of Hyoscyamine. Compare a few possible alternatives below.
Hyoscyamine
Used for:
$12.22Lowest GoodRx priceView prices
Used for:
$10.19Lowest GoodRx priceView prices
Used for:
  • Add-on treatment for stomach ulcers
$17.33Lowest GoodRx priceView prices
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News about Hyoscyamine

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Hyoscyamine images

White Round Pad And H - Hyoscyamine Sulfate 0.125mg Sublingual Tablet
This medicine is White, Round Sublingual Imprinted With "H" And "Pad".White Round Pad And H - Hyoscyamine Sulfate 0.125mg Sublingual Tablet
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This medicine is White, Round Sublingual Imprinted With "P39".White Round P39 - Hyoscyamine Sulfate 0.125mg Sublingual Tablet
Blue Round 113 And Ap - Hyoscyamine Sulfate 0.125mg Sublingual Tablet
This medicine is Blue, Round Sublingual Imprinted With "113" And "Ap".Blue Round 113 And Ap - Hyoscyamine Sulfate 0.125mg Sublingual Tablet
White Round 11 And Cl - Hyoscyamine Sulfate 0.125mg Sublingual Tablet
This medicine is White, Round Sublingual Imprinted With "11" And "Cl".White Round 11 And Cl - Hyoscyamine Sulfate 0.125mg Sublingual Tablet
Blue Round 105 And N - Hyoscyamine Sulfate 0.125mg Sublingual Tablet
This medicine is Blue, Round Sublingual Imprinted With "N" And "105".Blue Round 105 And N - Hyoscyamine Sulfate 0.125mg Sublingual Tablet

References

Best studies we found

Acella Pharmaceuticals, LLC. (2025). HYOSCYAMINE SULFATE TAB- hyoscyamine sulfate tablet [package insert]. DailyMed.

Acella Pharmaceuticals, LLC. (2025). Hyoscyamine sulfate ODT- hyoscyamine sulfate tablet, orally disintegrating [package insert]. DailyMed.

Acella Pharmaceuticals, LLC. (2025). Hyoscyamine sulfate SL- hyoscyamine sulfate tablet [package insert]. DailyMed.

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