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Hyoscyamine vs. Dicyclomine

Hyoscyamine sulfate is an anticholinergic medication used to treat conditions that involve muscle spasms in different parts of the body, including irritable bowel syndrome (IBS), stomach ulcers, and overactive bladder. It comes in several oral forms including immediate-release tablets, extended-release tablets, sublingual tablets, and liquid solutions. You typically take it by mouth 3 to 4 times a day. Some side effects include dry mouth, sleepiness, and dizziness.

• Stomach and intestine problems (e.g., stomach ulcers, stomach cramps, irritable bowel syndrome)
• Control spasms in certain conditions (e.g., overactive bladder)
• Pain from gallstones or kidney stones
• Runny nose
• Relief of certain symptoms (e.g., sweating, salivation, muscle rigidity, tremors) of Parkinson’s disease
• Colic in babies - oral solution only

• Dry mouth
• Trouble urinating
• Constipation
• Blurry vision
• Dry eyes
• Sleepiness
• Dizziness
• Headache
• Flushing
• Heat intolerance

• Dizziness
• Heat intolerance
• Intestinal blockage
• Faster heart rate
• Reduced saliva

Dicyclomine, also known by its brand name Bentyl, is an anticholinergic medication that's used to treat spasms of the muscles in the stomach and intestines in adults with irritable bowel syndrome (IBS). This medication is available as generic tablets, capsules, and liquid that are taken by mouth four times daily. There's also an injection form of dicyclomine that's available as brand name and generic; it's injected into the muscle for people who can't take pills by mouth. Common side effects include dizziness, dry mouth, and blurry vision.

• Irritable bowel syndrome (IBS)

• Dizziness (40%)
• Dry mouth (33%)
• Blurred vision (27%)
• Nausea (14%)

• Faster heart rate (caution in people with heart conditions)
• Changes in mood, thoughts, or behaviors
• Changes to bodily functions
• Muscle weakness (caution in people with myasthenia gravis)
• Strong caution in people with certain gut problems
• Trouble urinating (caution in people with prostate problems)