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Hyoscyamine vs. Glycopyrrolate

Hyoscyamine sulfate is an anticholinergic medication used to treat conditions that involve muscle spasms in different parts of the body, including irritable bowel syndrome (IBS), stomach ulcers, and overactive bladder. It comes in several oral forms including immediate-release tablets, extended-release tablets, sublingual tablets, and liquid solutions. You typically take it by mouth 3 to 4 times a day. Some side effects include dry mouth, sleepiness, and dizziness.

• Stomach and intestine problems (e.g., stomach ulcers, stomach cramps, irritable bowel syndrome)
• Control spasms in certain conditions (e.g., overactive bladder)
• Pain from gallstones or kidney stones
• Runny nose
• Relief of certain symptoms (e.g., sweating, salivation, muscle rigidity, tremors) of Parkinson’s disease
• Colic in babies - oral solution only

• Dry mouth
• Trouble urinating
• Constipation
• Blurry vision
• Dry eyes
• Sleepiness
• Dizziness
• Headache
• Flushing
• Heat intolerance

• Dizziness
• Heat intolerance
• Intestinal blockage
• Faster heart rate
• Reduced saliva

Glycopyrrolate (Robinul) is used with other medications to treat stomach ulcers. It's not as commonly used anymore due to newer available treatments and many unpleasant side effects. Glycopyrrolate is also available as Dartisla ODT, a tablet that dissolves when you put it on top of your tongue.

• Add-on treatment for stomach ulcers

• Dry mouth
• Less sweating
• Difficulty urinating
• Constipation
• Nausea
• Vomiting
• Feeling bloated

• Worsening glaucoma
• Heat stroke or fever
• Stomach blockage
• Drowsiness and blurred vision
• Worsening of other health conditions