Key takeaways
Xifaxan (rifaximin) and Bentyl (dicyclomine) are both used to treat conditions related to the digestive system, but they work in different ways and treat different issues. Xifaxan is a rifamycin antibiotic that treats travelers' diarrhea caused by *E. coli*, irritable bowel syndrome with diarrhea (IBS-D), and prevents hepatic encephalopathy (HE) in adults. It works by stopping bacteria in the gut from making proteins they need to survive. On the other hand, Bentyl is an anticholinergic medication that treats muscle spasms in the stomach and intestines for people with irritable bowel syndrome (IBS). It works by blocking acetylcholine, which helps relax the muscles in your gut. Xifaxan is taken 2 to 3 times a day, while Bentyl is taken 4 times a day. Xifaxan is only available as tablets, whereas Bentyl comes in multiple forms including tablets, capsules, oral liquid, and an injection. Common side effects of Xifaxan include swelling, dizziness, and fatigue, while Bentyl can cause dizziness, dry mouth, and blurry vision. Bentyl is available as a lower-cost generic, while Xifaxan is not.
