Head-to-head comparisons of medication uses, side effects, warnings, and more.
Key takeaways
Ibsrela (tenapanor) and Bentyl (dicyclomine) are both used to treat irritable bowel syndrome (IBS), but they work in different ways and treat different types of IBS. Ibsrela is specifically for IBS with constipation (IBS-C) and works by preventing sodium absorption in the gut, which helps soften stool and relieve constipation. Additionally, Ibsrela works on the nerves in the gut to relieve stomach pain. It is taken as a tablet twice a day before meals. Common side effects include diarrhea, bloating, and gas. On the other hand, Bentyl is an anticholinergic medication used to treat muscle spasms in the stomach and intestines for general IBS. It helps relax gut muscles by blocking acetylcholine from attaching to receptors in the gut and is taken four times a day. Common side effects include dizziness, dry mouth, and blurred vision. Bentyl is available in generic form and also as an injection for those who can't take oral medication, unlike Ibsrela which is only available in the oral dosage form and as a brand-name medication. Ibsrela is not recommended for children, while Bentyl is not suitable for people with certain heart conditions, glaucoma, or those who are breastfeeding.
Ibsrela (tenapanor)
Dicyclomine
Ibsrela (tenapanor)
Dicyclomine
Summary of Ibsrela vs. Bentyl
Summary for Sodium/hydrogen exchanger 3 (NHE3) inhibitor
Prescription only
Ibsrela (tenapanor) is used to treat adults with irritable bowel syndrome with constipation (IBS-C). This medication belongs to the drug class called sodium/hydrogen exchanger 3 (NHE3) inhibitors. Ibsrela (tenapanor) is a tablet that's taken by mouth twice per day. There aren't many side effects, but the most common is diarrhea. Other side effects include bloating, gas, and dizziness.
Summary for Anticholinergic
Prescription only
Dicyclomine, also known by its brand name Bentyl, is an anticholinergic medication that's used to treat spasms of the muscles in the stomach and intestines in adults with irritable bowel syndrome (IBS). This medication is available as generic tablets, capsules, and liquid that are taken by mouth four times daily. There's also an injection form of dicyclomine that's available as brand name and generic; it's injected into the muscle for people who can't take pills by mouth. Common side effects include dizziness, dry mouth, and blurry vision.