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Compare Linzess vs. Movantik

Head-to-head comparisons of medication uses, side effects, warnings, and more.

  • Linzess (linaclotide)
    Movantik (naloxegol)
  • Linzess (linaclotide)
    Movantik (naloxegol)

  • Summary of Linzess vs. Movantik

    Summary for GC-C agonist
    Prescription only

    Linzess (linaclotide) is a medication that can help with long-lasting constipation. It's approved for adults with constipation from irritable bowel syndrome (IBS) or other unknown reasons. It's also for children ages 6 to 17 who have functional constipation. Linzess (linaclotide) belongs to a drug class called guanylate cyclase-C agonists. It's a capsule that you take by mouth once a day. Diarrhea is a common side effect. Right now, Linzess (linaclotide) is only available as a brand-name medication. There's no generic version yet.

    Summary for Opioid antagonist
    Prescription only

    Movantik (naloxegol) is an opioid antagonist that's used to treat opioid-induced constipation, or constipation from opioid medications, in adults. It's a tablet that's taken by mouth once every morning on an empty stomach. The dosage is typically 25 mg, but it can be lowered to lessen side effects or risks from interactions with other medications. Common side effects include stomach pain, diarrhea, and nausea. Movantik (naloxegol) is available as a brand-name medication only; there's no lower-cost generic version yet.

  • Indications of Linzess vs. Movantik

    Indications for
    •Irritable bowel syndrome with constipation (IBS-C) in adults
    •Chronic idiopathic constipation (CIC) in adults
    •Functional constipation (FC) in children between 6 and 17 years old
    Indications for
    •Constipation from opioid pain medications in adults

  • Pros and Cons of Linzess vs. Movantik

    Pros and Const for GC-C agonist
    Pros
    •Only need to take once a day
    •Can start to see improvement as early as a week of taking it every day
    Cons
    •Must take on an empty stomach (30 minutes before a meal)
    •Can cause diarrhea
    Pros and Const for Opioid antagonist
    Pros
    •A good option to help with constipation from opioids
    •Taken by mouth once a day
    •Tablets can be crushed and mixed with water for people who have trouble swallowing them whole
    Cons
    •Must take on an empty stomach
    •Might have opioid withdrawal symptoms
    •Might not work as well if you've been taking opioids for less than 1 month

  • Common Side Effects of Linzess vs. Movantik

    Common Side Effects for

    Adults Note: Side effects reported for IBS-C. Side effects might differ for CIC. <br>

    •Diarrhea (20%)
    •Stomach pain (7%)
    •Having gas (4%)
    •Bloating and feeling full in the belly (2%)

    Children

    •Diarrhea (4%)
    Common Side Effects for
    •Stomach pain (up to 21%)
    •Diarrhea (up to 9%)
    •Nausea (up to 8%)

  • Warnings of Linzess vs. Movantik

    Common Side Effects for
    •Not for children younger than 2 years of age because of risk of serious dehydration
    •Severe diarrhea
    Common Side Effects for
    •Opioid withdrawal
    •Severe stomach pain or diarrhea
    •Gastrointestinal (stomach or intestinal) injury
    •Allergic reaction

  • Prices with our coupons for Linzess vs. Movantik

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