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Compare Amitiza vs. Linzess

Head-to-head comparisons of medication uses, side effects, warnings, and more.

  • Lubiprostone (Amitiza)
    Linzess (linaclotide)
  • Lubiprostone (Amitiza)
    Linzess (linaclotide)

  • Summary of Amitiza vs. Linzess

    Summary for Chloride Channel Activator
    Prescription only

    Lubiprostone (Amitiza) is a good option for treating various types of constipation if other medications are not working well enough. It's available as a generic, which may not be much cheaper if it's not covered by insurance.

    Summary for GC-C agonist
    Prescription only

    Linzess (linaclotide) is a medication that can help with long-lasting constipation. It's approved for adults with constipation from irritable bowel syndrome (IBS) or other unknown reasons. It's also for children ages 6 to 17 who have functional constipation. Linzess (linaclotide) belongs to a drug class called guanylate cyclase-C agonists. It's a capsule that you take by mouth once a day. Diarrhea is a common side effect. Right now, Linzess (linaclotide) is only available as a brand-name medication. There's no generic version yet.

  • Indications of Amitiza vs. Linzess

    Indications for
    •Long-term constipation due to unclear cause (idiopathic)
    •Constipation due to opioids
    •Constipation due to irritiable bowel syndrome (IBS) in women 18 years or older
    Indications for
    •Irritable bowel syndrome with constipation (IBS-C) in adults
    •Chronic idiopathic constipation (CIC) in adults
    •Functional constipation (FC) in children between 6 and 17 years old

  • Pros and Cons of Amitiza vs. Linzess

    Pros and Const for Chloride Channel Activator
    Pros
    •Works in a unique way to treat constipation (it's the only medication in its class)
    •Treats constipation that hasn't responded well to other medications
    •Available as a generic form, though it may still be expensive
    Cons
    •Not approved for people with constipation caused by opioids for cancer-related pain
    •Not approved for children
    •Only available as a capsule that must be swallowed whole
    •Can cause nausea and diarrhea
    Pros and Const for GC-C agonist
    Pros
    •Only need to take once a day
    •Can start to see improvement as early as a week of taking it every day
    Cons
    •Must take on an empty stomach (30 minutes before a meal)
    •Can cause diarrhea

  • Common Side Effects of Amitiza vs. Linzess

    Common Side Effects for
    •Nausea (>4%)
    •Diarrhea (>4%)
    Common Side Effects for

    Adults Note: Side effects reported for IBS-C. Side effects might differ for CIC. <br>

    •Diarrhea (20%)
    •Stomach pain (7%)
    •Having gas (4%)
    •Bloating and feeling full in the belly (2%)

    Children

    •Diarrhea (4%)

  • Warnings of Amitiza vs. Linzess

    Common Side Effects for
    •Low blood pressure and fainting
    •Difficulty breathing
    •Intestinal blockage
    Common Side Effects for
    •Not for children younger than 2 years of age because of risk of serious dehydration
    •Severe diarrhea

  • Prices with our coupons for Amitiza vs. Linzess

    Learn more about Lubiprostone
    Learn more about Linzess

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