Chloride channel activators are used to treat chronic idiopathic constipation, irritable bowel syndrome with constipation, and opioid-induced constipation. These medications work by activating chloride channels in the intestines, which helps increase fluid secretion to soften stool and improve bowel movements. Chloride channel activators are available in oral form. An example is lubiprostone (Amitiza). This medication can help you manage your constipation more effectively.