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Compare Levsin vs. Viberzi

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Hyoscyamine (Levsin, Hyosyne, Symax, Oscimin, NuLev) and Viberzi (eluxadoline) are both medications used to treat irritable bowel syndrome (IBS), but they belong to different medication classes. Hyoscyamine is an anticholinergic medication that helps with symptoms like stomach cramps and overactive bladder by blocking acetylcholine, while Viberzi is an opioid receptor agonist/antagonist that targets opioid receptors to relieve IBS with diarrhea (IBS-D) symptoms. Hyoscyamine is available in various oral forms, such as tablets and liquid, and is taken multiple times a day, whereas Viberzi is an oral tablet taken twice daily with food. Hyoscyamine is available as a lower-cost generic, while Viberzi is only available as a brand-name medication. Additionally, Viberzi is a controlled substance due to its potential for misuse and dependence. Common side effects of hyoscyamine include dry mouth and dizziness, while Viberzi can cause constipation and nausea. Additionally, Viberzi carries a risk of pancreatitis, especially in people without a gallbladder and those who consume excessive amounts of alcohol.

  • Hyoscyamine
    Viberzi (eluxadoline)
  • Hyoscyamine
    Viberzi (eluxadoline)

  • Summary of Levsin vs. Viberzi

    Summary for Anticholinergic
    Prescription only

    Hyoscyamine sulfate is an anticholinergic medication. It can ease symptoms of different conditions, including irritable bowel syndrome (IBS), stomach ulcers, and overactive bladder, in adults and children. Hyoscyamine is taken by mouth, typically every 4 hours. It's available in many dosage forms, including immediate-release tablets, sublingual tablets, and oral solution. Some side effects of hyoscyamine include dry mouth, sleepiness, and dizziness.

    Summary for Opioid receptor agonist/antagonist
    Prescription only

    Viberzi (eluxadoline) is a prescription medication used to treat irritable bowel syndrome with diarrhea (IBS-D) in adults. It works on the opioid receptor to help ease symptoms such as stomach pain and diarrhea. You typically take a dose by mouth twice a day with food. Because of its potential for misuse and dependence, it’s considered a controlled substance. Common side effects include constipation, nausea, and stomach pain.

  • Indications of Levsin vs. Viberzi

    Indications for
    •Stomach and intestine problems (e.g., stomach ulcers, stomach cramps, irritable bowel syndrome)
    •Control spasms in certain conditions (e.g., overactive bladder)
    •Colic in babies (Hyoscyamine elixir and drops only)
    •Pain from gallstones or kidney stones
    •Runny nose
    •Relief of certain symptoms (e.g., sweating, salivation, muscle rigidity, tremors) of Parkinson’s disease
    Indications for
    •Irritable bowel syndrome with diarrhea (IBS-D) in adults

  • Pros and Cons of Levsin vs. Viberzi

    Pros and Const for Anticholinergic
    Pros
    •Works quickly to relieve symptoms
    •Comes in several different dosage forms (e.g., oral tablet, sublingual tablet, orally dissolving tablet, liquid)
    •Can be used in adults and children
    •Available as a lower-cost generic
    Cons
    •Needs to be taken multiple times per day
    •Can have a lot of bothersome side effects (e.g., sleepiness, dizziness, dry mouth, trouble urinating, constipation)
    •Not known if it's safe for people who are pregnant or breastfeeding because it hasn't been studied
    Pros and Const for Opioid receptor agonist/antagonist
    Pros
    •Tablet that's taken by mouth
    •Typically works within a week
    •Approved for males and females with IBS-D
    Cons
    •Must be taken twice a day with food
    •Is a controlled substance
    •Risk of pancreatitis, inflammation of the pancreas

  • Common Side Effects of Levsin vs. Viberzi

    Common Side Effects for
    •Dry mouth
    •Trouble urinating
    •Constipation
    •Blurry vision
    •Dry eyes
    •Sleepiness
    •Dizziness
    •Headache
    •Flushing
    •Head intolerance
    Common Side Effects for
    •Constipation (8%)
    •Nausea (7%)
    •Stomach pain (7%)

  • Warnings of Levsin vs. Viberzi

    Common Side Effects for
    •Dizziness
    •Changes in mood, thoughts, or behaviors
    •Faster heart rate
    •Changes to bodily functions
    •Trouble urinating
    •Caution in people with certain gut problems
    Common Side Effects for
    •Pancreatitis
    •Bile duct muscle spasm
    •Allergic reactions
    •Constipation

  • Prices with our coupons for Levsin vs. Viberzi

    Learn more about Hyoscyamine
    Learn more about Viberzi

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