Key takeaways
Linzess (linaclotide) and Motegrity (prucalopride) are both used to treat chronic constipation, but they work in different ways and have some key differences. Linzess is a guanylate cyclase-C (GC-C) agonist that increases fluid in the intestines to help with bowel movements and is taken on an empty stomach once a day. Motegrity, on the other hand, is a serotonin-4 receptor agonist that stimulates gut movement and can be taken with or without food once a day. Both medications are available as brand only medications. Common side effects of Linzess include diarrhea and stomach pain, whereas Motegrity often causes headaches and nausea. Additionally, Motegrity has a warning for potential mood changes and suicidal thoughts, which is not a concern with Linzess. Both medications should be taken consistently, but you should consult your healthcare professional to determine which is best for you.
